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Hafler Laboratory Publications
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Hafler Laboratory Publications

Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49].Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. J Autoimmun. 2019 Aug; 2019 May 18. PMID: 31109655.
Author Correction: Activated β-catenin in Foxp3⁺ regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Nat Immunol. 2019 Jul. PMID: 31175348.
TIGIT signaling restores suppressor function of Th1 Tregs.Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. JCI Insight. 2019 Feb 7; 2019 Feb 7. PMID: 30728325.
Multiple sclerosis enters a grey area.Pappalardo JL, Hafler DA. Nature. 2019 Feb. PMID: 30809050.
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. J Autoimmun. 2019 Jan; 2018 Aug 16. PMID: 30122421.
Activated β-catenin in Foxp3⁺ regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Nat Immunol. 2018 Dec; 2018 Oct 29. PMID: 30374130.
Regulatory T cells in autoimmune disease.Dominguez-Villar M, Hafler DA. Nat Immunol. 2018 Jul; 2018 Jun 20. PMID: 29925983.
Podoplanin is a negative regulator of Th17 inflammation.Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. JCI Insight. 2017 Sep 7; 2017 Sep 7. PMID: 28878118.
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.Lucca LE, Hafler DA. J Clin Invest. 2017 Apr 3; 2017 Mar 20. PMID: 28319049.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.Lucca LE, Hafler DA. Immunol Rev. 2017 Mar. PMID: 28258696.
The Human Functional Genomics Project: Understanding Generation of Diversity.Pappalardo JL, Hafler DA. Cell. 2016 Nov 3. PMID: 27814519.
Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.Longbrake EE, Hafler DA. JAMA Neurol. 2016 Jul 1. PMID: 27244583.
Multiple sclerosis: genetics, biomarkers, treatments.Axisa PP, Hafler DA. Curr Opin Neurol. 2016 Jun. PMID: 27058221.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. JCI Insight. 2016 Apr 21. PMID: 27182555.
The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA. Curr Drug Targets. 2016. PMID: 26844569.
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. J Clin Invest. 2015 Nov 2; 2015 Oct 20. PMID: 26524592.
Biomarkers in multiple sclerosis.Housley WJ, Pitt D, Hafler DA. Clin Immunol. 2015 Nov; 2015 Jul 2. PMID: 26143623.
Sodium-activated macrophages: the salt mine expands.Lucca LE, Hafler DA. Cell Res. 2015 Aug; 2015 Jul 28. PMID: 26215700.
Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Sci Transl Med. 2015 Jun 10. PMID: 26062845.
Genetic basis of autoimmunity.Marson A, Housley WJ, Hafler DA. J Clin Invest. 2015 Jun; 2015 Jun 1. PMID: 26030227.
Thymic selection: to thine own self be true.Kitz A, Hafler DA. Immunity. 2015 May 19. PMID: 25992854.
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Sci Transl Med. 2015 May 13. PMID: 25972006.
TLR7 induces anergy in human CD4(+) T cells.Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. Nat Immunol. 2015 Jan; 2014 Nov 17. PMID: 25401424.
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA. Eur J Immunol. 2014 Sep; 2014 Jun 16. PMID: 24838857.
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. J Clin Invest. 2014 Jun; 2014 May 8. PMID: 24812667.
Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld M, Hafler DA. Immunol Rev. 2014 May. PMID: 24712469.
The plasticity of human Treg and Th17 cells and its role in autoimmunity.Kleinewietfeld M, Hafler DA. Semin Immunol. 2013 Nov 15; 2013 Nov 5. PMID: 24211039.
The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. J Immunol. 2013 Oct 1; 2013 Aug 26. PMID: 23980210.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Nature. 2013 Apr 25; 2013 Mar 6. PMID: 23467095.
Immune-mediated disease genetics: the shared basis of pathogenesis.Cotsapas C, Hafler DA. Trends Immunol. 2013 Jan; 2012 Sep 29. PMID: 23031829.
Regulatory T cells in the central nervous system.Lowther DE, Hafler DA. Immunol Rev. 2012 Jul. PMID: 22725960.
The TIGIT/CD226 axis regulates human T cell function.Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. J Immunol. 2012 Apr 15; 2012 Mar 16. PMID: 22427644.
Perspective: Deconstructing a disease.Hafler DA. Nature. 2012 Apr 12. PMID: 22509507.
Multiple sclerosis.Nylander A, Hafler DA. J Clin Invest. 2012 Apr; 2012 Apr 2. PMID: 22466660.
Fingolimod for multiple sclerosis.Pelletier D, Hafler DA. N Engl J Med. 2012 Jan 26. PMID: 22276823.
Class II MHC self-antigen presentation in human B and T lymphocytes.Costantino CM, Spooner E, Ploegh HL, Hafler DA. PLoS One. 2012; 2012 Jan 27. PMID: 22299025.
The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. J Immunol. 2011 Sep 15; 2011 Aug 17. PMID: 21849685.
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. J Immunol. 2011 Jul 15; 2011 Jun 8. PMID: 21653833.
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Nat Med. 2011 Jun; 2011 May 3. PMID: 21540856.
Immunology. An innate role for IL-17.Dominguez-Villar M, Hafler DA. Science. 2011 Apr 1. PMID: 21454778.
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. J Immunol. 2011 Mar 15; 2011 Feb 7. PMID: 21300823.
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Brain. 2011 Feb; 2011 Jan 7. PMID: 21216828.
Human regulatory T cells in autoimmune diseases.Cvetanovich GL, Hafler DA. Curr Opin Immunol. 2010 Dec; 2010 Sep 24. PMID: 20869862.
TGF-beta induces IL-9 production from human Th17 cells.Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. J Immunol. 2010 Jul 1; 2010 May 24. PMID: 20498357.
FOXP3+ regulatory T cells in the human immune system.Sakaguchi S, Miyara M, Costantino CM, Hafler DA. Nat Rev Immunol. 2010 Jul; 2010 Jun 18. PMID: 20559327.
T-cells in multiple sclerosis.Severson C, Hafler DA. Results Probl Cell Differ. 2010. PMID: 19582415.
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. J Immunol. 2009 Oct 1; 2009 Sep 11. PMID: 19748982.
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.Costantino CM, Ploegh HL, Hafler DA. J Immunol. 2009 Jul 15; 2009 Jun 24. PMID: 19553543.
Autoimmunity risk alleles in costimulation pathways.Maier LM, Hafler DA. Immunol Rev. 2009 May. PMID: 19426231.
IL-17-producing human peripheral regulatory T cells retain suppressive function.Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. Blood. 2009 Apr 30; 2009 Jan 26. PMID: 19171879.
The role of the CD58 locus in multiple sclerosis.De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. Proc Natl Acad Sci U S A. 2009 Mar 31; 2009 Feb 23. PMID: 19237575.
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. J Immunol. 2009 Feb 1. PMID: 19155502.
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA, Hafler DA. PLoS Genet. 2009 Jan; 2009 Jan 2. PMID: 19119414.
Multiple sclerosis and regulatory T cells.Costantino CM, Baecher-Allan C, Hafler DA. J Clin Immunol. 2008 Nov; 2008 Sep 2. PMID: 18763026.
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. Nature. 2008 Jul 17; 2008 May 11. PMID: 18469800.
Human regulatory T cells and autoimmunity.Costantino CM, Baecher-Allan CM, Hafler DA. Eur J Immunol. 2008 Apr. PMID: 18395861.
Lack of TIM-3 immunoregulation in multiple sclerosis.Yang L, Anderson DE, Kuchroo J, Hafler DA. J Immunol. 2008 Apr 1. PMID: 18354161.
The developing mosaic of autoimmune disease risk.Maier LM, Hafler DA. Nat Genet. 2008 Feb. PMID: 18227869.
Allelic variant in CTLA4 alters T cell phosphorylation patterns.Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Proc Natl Acad Sci U S A. 2007 Nov 20; 2007 Nov 13. PMID: 18000051.
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Science. 2007 Nov 16. PMID: 18006747.
Abnormal Tr1 differentiation in multiple sclerosis.Astier AL, Hafler DA. J Neuroimmunol. 2007 Nov; 2007 Oct 22. PMID: 17936368.
Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes.Cai G, Hafler DA. Eur J Immunol. 2007 Mar. PMID: 17304631.
New therapeutic approaches for multiple sclerosis.De Jager PL, Hafler DA. Annu Rev Med. 2007. PMID: 17217332.
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.Astier AL, Meiffren G, Freeman S, Hafler DA. J Clin Invest. 2006 Dec; 2006 Nov 9. PMID: 17099776.
Human regulatory T cells and their role in autoimmune disease.Baecher-Allan C, Hafler DA. Immunol Rev. 2006 Aug. PMID: 16903916.
Dysregulated T cell expression of TIM3 in multiple sclerosis.Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. J Exp Med. 2006 Jun 12; 2006 Jun 5. PMID: 16754722.
The purification and functional analysis of human CD4+CD25high regulatory T cells.Baecher-Allan CM, Hafler DA. Curr Protoc Immunol. 2006 May. PMID: 18432975.
MHC class II expression identifies functionally distinct human regulatory T cells.Baecher-Allan C, Wolf E, Hafler DA. J Immunol. 2006 Apr 15. PMID: 16585553.
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells.Baecher-Allan CM, Hafler DA. Clin Immunol. 2005 Nov. PMID: 16214081.
Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells.Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. J Immunol. 2005 Oct 1. PMID: 16177088.
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. Nat Genet. 2005 Oct; 2005 Sep 25. PMID: 16186815.
Characterization of in vivo expanded OspA-specific human T-cell clones.Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Clin Immunol. 2005 Jun. PMID: 15893699.
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Nature. 2005 May 12. PMID: 15889096.
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells.Baecher-Allan C, Wolf E, Hafler DA. Clin Immunol. 2005 Apr. PMID: 15870015.
Suppressor T cells in human diseases.Baecher-Allan C, Hafler DA. J Exp Med. 2004 Aug 2; 2004 Jul 26. PMID: 15280423.
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. J Immunol. 2004 Aug 1. PMID: 15265898.
Re: GAMES issue study: Are international genetic consortia functional?De Jager PL, Walsh EC, Rioux JD, Hafler DA. J Neuroimmunol. 2004 Aug. PMID: 15334748.
Gene expression profiling in MS: what is the clinical relevance?De Jager PL, Hafler DA. Lancet Neurol. 2004 May. PMID: 15099539.
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. J Exp Med. 2004 Apr 5. PMID: 15067033.
Human CD4+CD25+ regulatory T cells.Baecher-Allan C, Viglietta V, Hafler DA. Semin Immunol. 2004 Apr. PMID: 15036232.
Multiple sclerosis.Hafler DA. J Clin Invest. 2004 Mar. PMID: 15067307.
Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.Slavik JM, Lim DG, Burakoff SJ, Hafler DA. J Biol Chem. 2004 Jan 9; 2003 Oct 22. PMID: 14573608.
Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.Lim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. J Exp Med. 2003 Jul 7. PMID: 12847139.
In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis.Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. Clin Immunol. 2003 Mar. PMID: 12706402.
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. J Neuroimmunol. 2003 Mar. PMID: 12620653.
Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.Buckle GJ, Höllsberg P, Hafler DA. Neurology. 2003 Feb 25. PMID: 12601116.
CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls.Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. J Autoimmun. 2003 Feb. PMID: 12604314.
CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo.Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. Novartis Found Symp. 2003. PMID: 14609213.
Inhibition of human CD4(+)CD25(+high) regulatory T cell function.Baecher-Allan C, Viglietta V, Hafler DA. J Immunol. 2002 Dec 1. PMID: 12444126.
Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells.Lim DG, Höllsberg P, Hafler DA. Cell Immunol. 2002 May-Jun. PMID: 12425999.
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes.Viglietta V, Kent SC, Orban T, Hafler DA. J Clin Invest. 2002 Apr. PMID: 11927616.
Degeneracy, as opposed to specificity, in immunotherapy.Hafler DA. J Clin Invest. 2002 Mar. PMID: 11877465.
Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. J Immunol. 2001 Nov 15. PMID: 11698439.
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure.Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. J Virol. 2001 Oct. PMID: 11559817.
In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG.Ohashi T, Yukitake M, Slavin A, Krieger J, Hafler DA. J Neuroimmunol. 2001 Aug 30. PMID: 11498254.
CD4+CD25high regulatory cells in human peripheral blood.Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. J Immunol. 2001 Aug 1. PMID: 11466340.
The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis.O'Connor KC, Bar-Or A, Hafler DA. J Clin Immunol. 2001 Mar. PMID: 11332657.
Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes.Slavik JM, Lim DG, Burakoff SJ, Hafler DA. J Immunol. 2001 Mar 1. PMID: 11207273.
Immune tolerance and the nervous system.Anderson DE, Hafler DA. Adv Exp Med Biol. 2001. PMID: 11505978.
Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset.Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Autoimmunity. 2001. PMID: 11905851.