Publications

• pHLIP targeted intracellular delivery of calicheamicin.DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman DM, Andreev OA, Moshnikova A, Reshetnyak YK. Int J Pharm. 2024 Apr 10; 2024 Feb 28. PMID: 38428548.
• Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides.Reshetnyak YK, Andreev OA, Engelman DM. Front Pharmacol. 2024; 2024 Mar 13. PMID: 38545547.
• Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors.Moshnikova A, DuPont M, Iraca M, Klumpp C, Visca H, Allababidi D, Pelzer P, Engelman DM, Andreev OA, Reshetnyak YK. Front Pharmacol. 2024; 2024 Mar 1. PMID: 38495104.
• Tumor treatment by pHLIP-targeted antigen delivery.DuPont M, Visca H, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA. Front Bioeng Biotechnol. 2022; 2023 Jan 6. PMID: 36686229.
• pHLIP Peptides Target Acidity in Activated Macrophages.Visca H, DuPont M, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK. Mol Imaging Biol. 2022 Dec; 2022 May 23. PMID: 35604527.
• Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP.Moshnikova A, DuPont M, Visca H, Engelman DM, Andreev OA, Reshetnyak YK. Front Oncol. 2022; 2022 Oct 18. PMID: 36330464.
• Taking out the trash: How misfolded proteins are removed from the endoplasmic reticulum.Brodsky JL, Engelman DM, Hendershot LM, Piana-Agostinetti S, Sommer T. Fac Rev. 2022; 2022 Oct 5. PMID: 36267301.
• Targeting Bladder Urothelial Carcinoma with pHLIP-ICG and Inhibition of Urothelial Cancer Cell Proliferation by pHLIP-amanitin.Moshnikova A, Golijanin B, Amin A, Doyle J, Kott O, Gershman B, DuPont M, Li Y, Lu X, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D. Front Urol. 2022; 2022 Aug 24. PMID: 36439552.
• Correction to 'Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity'.Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. NAR Cancer. 2021 Dec; 2021 Dec 7. PMID: 34888524.
• MicroRNA function can be reversed by altering target gene expression levels.Svoronos AA, Campbell SG, Engelman DM. iScience. 2021 Oct 22; 2021 Oct 2. PMID: 34755085.
• Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity.Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. NAR Cancer. 2021 Jun; 2021 Jun 4. PMID: 34316708.
• Pharmacokinetic modeling reveals parameters that govern tumor targeting and delivery by a pH-Low Insertion Peptide (pHLIP).Svoronos AA, Engelman DM. Proc Natl Acad Sci U S A. 2021 Jan 5; 2020 Dec 21. PMID: 33443162.
• pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery.Crawford T, Moshnikova A, Roles S, Weerakkody D, DuPont M, Carter LM, Shen J, Engelman DM, Lewis JS, Andreev OA, Reshetnyak YK. Sci Rep. 2020 Oct 27; 2020 Oct 27. PMID: 33110131.
• Kinetics of pHLIP peptide insertion into and exit from a membrane.Slaybaugh G, Weerakkody D, Engelman DM, Andreev OA, Reshetnyak YK. Proc Natl Acad Sci U S A. 2020 Jun 2; 2020 May 14. PMID: 32409607.
• Ku80-Targeted pH-Sensitive Peptide-PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation.Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Mol Cancer Res. 2020 Jun; 2020 Feb 25. PMID: 32098827.
• Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding.Reshetnyak YK, Moshnikova A, Andreev OA, Engelman DM. Front Bioeng Biotechnol. 2020; 2020 Apr 28. PMID: 32411684.
• Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide.Svoronos AA, Bahal R, Pereira MC, Barrera FN, Deacon JC, Bosenberg M, DiMaio D, Glazer PM, Engelman DM. Mol Pharm. 2020 Feb 3; 2020 Jan 13. PMID: 31855437.
• Mapping pH at Cancer Cell Surfaces.Wei D, Engelman DM, Reshetnyak YK, Andreev OA. Mol Imaging Biol. 2019 Dec. PMID: 30989440.
• Applications of pHLIP Technology for Cancer Imaging and Therapy: (Trends in Biotechnology 35, 653-664, 2017).Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM. Trends Biotechnol. 2018 Dec; 2017 Nov 30. PMID: 29198980.
• Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.Karabadzhak AG, Weerakkody D, Deacon J, Andreev OA, Reshetnyak YK, Engelman DM. Biophys J. 2018 May 8. PMID: 29742404.
• Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors.Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK. Proc Natl Acad Sci U S A. 2018 Mar 20; 2018 Mar 5. PMID: 29507241.
• Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.Karabadzhak AG, Petti LM, Barrera FN, Edwards APB, Moya-Rodríguez A, Polikanov YS, Freites JA, Tobias DJ, Engelman DM, DiMaio D. Proc Natl Acad Sci U S A. 2017 Aug 29; 2017 Aug 14. PMID: 28808001.
• Applications of pHLIP Technology for Cancer Imaging and Therapy.Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM. Trends Biotechnol. 2017 Jul; 2017 Apr 21. PMID: 28438340.
• Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D. Proc Natl Acad Sci U S A. 2016 Oct 18; 2016 Sep 29. PMID: 27688767.
• PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study.Demoin DW, Wyatt LC, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS. Bioconjug Chem. 2016 Sep 21; 2016 Jul 21. PMID: 27396694.
• Probe for the measurement of cell surface pH in vivo and ex vivo.Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA. Proc Natl Acad Sci U S A. 2016 Jul 19; 2016 Jul 5. PMID: 27382181.
• OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.Svoronos AA, Engelman DM, Slack FJ. Cancer Res. 2016 Jul 1; 2016 Jun 20. PMID: 27325641.
• Membranes Do Not Tell Proteins How To Fold.Popot JL, Engelman DM. Biochemistry. 2016 Jan 12; 2015 Dec 19. PMID: 26649989.
• Biologically active LIL proteins built with minimal chemical diversity.Heim EN, Marston JL, Federman RS, Edwards AP, Karabadzhak AG, Petti LM, Engelman DM, DiMaio D. Proc Natl Acad Sci U S A. 2015 Aug 25; 2015 Aug 10. PMID: 26261320.
• The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. Proc Natl Acad Sci U S A. 2015 Aug 4; 2015 Jul 20. PMID: 26195776.
• MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. Nature. 2015 Feb 5; 2014 Nov 17. PMID: 25409146.
• Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP.Deacon JC, Engelman DM, Barrera FN. Arch Biochem Biophys. 2015 Jan 1; 2014 Nov 18. PMID: 25444855.
• pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo.Karabadzhak AG, An M, Yao L, Langenbacher R, Moshnikova A, Adochite RC, Andreev OA, Reshetnyak YK, Engelman DM. ACS Chem Biol. 2014 Nov 21; 2014 Sep 10. PMID: 25184440.
• Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS. Proc Natl Acad Sci U S A. 2014 May 20; 2014 May 1. PMID: 24785505.
• Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor.Cohen EB, Jun SJ, Bears Z, Barrera FN, Alonso M, Engelman DM, DiMaio D. PLoS One. 2014; 2014 Apr 30. PMID: 24788775.
• Targeting diseased tissues by pHLIP insertion at low cell surface pH.Andreev OA, Engelman DM, Reshetnyak YK. Front Physiol. 2014; 2014 Mar 13. PMID: 24659971.
• Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD. J Virol. 2014 Jan; 2013 Oct 30. PMID: 24173222.
• Aspartate embedding depth affects pHLIP's insertion pKa.Fendos J, Barrera FN, Engelman DM. Biochemistry. 2013 Jul 9; 2013 Jun 27. PMID: 23721379.
• Family of pH (low) insertion peptides for tumor targeting.Weerakkody D, Moshnikova A, Thakur MS, Moshnikova V, Daniels J, Engelman DM, Andreev OA, Reshetnyak YK. Proc Natl Acad Sci U S A. 2013 Apr 9; 2013 Mar 25. PMID: 23530249.
• Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VT, Engelman DM, Engelward BP. Future Microbiol. 2013 Feb. PMID: 23374130.
• pHLIP peptide targets nanogold particles to tumors.Yao L, Daniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK, Andreev OA. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 24. PMID: 23267062.
• pH (low) insertion peptide (pHLIP) targets ischemic myocardium.Sosunov EA, Anyukhovsky EP, Sosunov AA, Moshnikova A, Wijesinghe D, Engelman DM, Reshetnyak YK, Andreev OA. Proc Natl Acad Sci U S A. 2013 Jan 2; 2012 Dec 17. PMID: 23248283.
• In vivo pH imaging with (99m)Tc-pHLIP.Macholl S, Morrison MS, Iveson P, Arbo BE, Andreev OA, Reshetnyak YK, Engelman DM, Johannesen E. Mol Imaging Biol. 2012 Dec. PMID: 22371188.
• Membrane physical properties influence transmembrane helix formation.Barrera FN, Fendos J, Engelman DM. Proc Natl Acad Sci U S A. 2012 Sep 4; 2012 Aug 20. PMID: 22908237.
• Modulation of the pHLIP transmembrane helix insertion pathway.Karabadzhak AG, Weerakkody D, Wijesinghe D, Thakur MS, Engelman DM, Andreev OA, Markin VS, Reshetnyak YK. Biophys J. 2012 Apr 18. PMID: 22768940.
• Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP.Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA. Mol Imaging Biol. 2011 Dec. PMID: 21181501.
• Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK. Biochemistry. 2011 Nov 29; 2011 Nov 4. PMID: 22029270.
• Roles of carboxyl groups in the transmembrane insertion of peptides.Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM. J Mol Biol. 2011 Oct 21; 2011 Aug 23. PMID: 21888917.
• Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.Matthews EE, Thévenin D, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, Engelman DM. FASEB J. 2011 Jul; 2011 Mar 14. PMID: 21402716.
• pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation.An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM. Proc Natl Acad Sci U S A. 2010 Nov 23; 2010 Nov 3. PMID: 21048084.
• The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein.Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, Matsuda Z. Retrovirology. 2010 Nov 13; 2010 Nov 13. PMID: 21073746.
• pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents.Andreev OA, Engelman DM, Reshetnyak YK. Mol Membr Biol. 2010 Oct; 2010 Oct 13. PMID: 20939768.
• Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families.Patel PV, Gianoulis TA, Bjornson RD, Yip KY, Engelman DM, Gerstein MB. Genome Res. 2010 Jul; 2010 Apr 29. PMID: 20430783.
• Tuning the insertion properties of pHLIP.Musial-Siwek M, Karabadzhak A, Andreev OA, Reshetnyak YK, Engelman DM. Biochim Biophys Acta. 2010 Jun; 2009 Sep 18. PMID: 19766589.
• pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path.Andreev OA, Karabadzhak AG, Weerakkody D, Andreev GO, Engelman DM, Reshetnyak YK. Proc Natl Acad Sci U S A. 2010 Mar 2; 2010 Feb 16. PMID: 20160113.
• Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor.Cammett TJ, Jun SJ, Cohen EB, Barrera FN, Engelman DM, Dimaio D. Proc Natl Acad Sci U S A. 2010 Feb 23; 2010 Feb 8. PMID: 20142506.
• Computational analysis of membrane proteins: the largest class of drug targets.Arinaminpathy Y, Khurana E, Engelman DM, Gerstein MB. Drug Discov Today. 2009 Dec; 2009 Sep 3. PMID: 19733256.
• Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, Dimaio D. J Virol. 2009 Oct; 2009 Jul 15. PMID: 19605488.
• Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1.Kim JH, Hartley TL, Curran AR, Engelman DM. Biochim Biophys Acta. 2009 Sep; 2009 Jun 21. PMID: 19540828.
• Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP).Segala J, Engelman DM, Reshetnyak YK, Andreev OA. Int J Mol Sci. 2009 Aug 4; 2009 Aug 4. PMID: 20111691.
• pHLIP-mediated translocation of membrane-impermeable molecules into cells.Thévenin D, An M, Engelman DM. Chem Biol. 2009 Jul 31. PMID: 19635412.
• A novel technology for the imaging of acidic prostate tumors by positron emission tomography.Vāvere AL, Biddlecombe GB, Spees WM, Garbow JR, Wijesinghe D, Andreev OA, Engelman DM, Reshetnyak YK, Lewis JS. Cancer Res. 2009 May 15; 2009 May 5. PMID: 19417132.
• Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP).Andreev OA, Engelman DM, Reshetnyak YK. Chim Oggi. 2009 Mar 1. PMID: 20037661.
• Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane.Reshetnyak YK, Andreev OA, Segala M, Markin VS, Engelman DM. Proc Natl Acad Sci U S A. 2008 Oct 7; 2008 Sep 30. PMID: 18829441.
• Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors.Zoonens M, Reshetnyak YK, Engelman DM. Biophys J. 2008 Jul; 2008 Mar 21. PMID: 18359793.
• Bacteriorhodopsin/amphipol complexes: structural and functional properties.Gohon Y, Dahmane T, Ruigrok RW, Schuck P, Charvolin D, Rappaport F, Timmins P, Engelman DM, Tribet C, Popot JL, Ebel C. Biophys J. 2008 May 1; 2008 Jan 11. PMID: 18192360.
• Protein area occupancy at the center of the red blood cell membrane.Dupuy AD, Engelman DM. Proc Natl Acad Sci U S A. 2008 Feb 26; 2008 Feb 19. PMID: 18287056.
• An integrated system for studying residue coevolution in proteins.Yip KY, Patel P, Kim PM, Engelman DM, McDermott D, Gerstein M. Bioinformatics. 2008 Jan 15; 2007 Dec 1. PMID: 18056067.
• A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers.Reshetnyak YK, Segala M, Andreev OA, Engelman DM. Biophys J. 2007 Oct 1; 2007 Jun 8. PMID: 17557792.
• Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo.Andreev OA, Dupuy AD, Segala M, Sandugu S, Serra DA, Chichester CO, Engelman DM, Reshetnyak YK. Proc Natl Acad Sci U S A. 2007 May 8; 2007 May 1. PMID: 17483464.
• Dynamic helix interactions in transmembrane signaling.Matthews EE, Zoonens M, Engelman DM. Cell. 2006 Nov 3. PMID: 17081964.
• The stability of transmembrane helix interactions measured in a biological membrane.Finger C, Volkmer T, Prodöhl A, Otzen DE, Engelman DM, Schneider D. J Mol Biol. 2006 May 19; 2006 Mar 13. PMID: 16574146.
• Invariant chain transmembrane domain trimerization: a step in MHC class II assembly.Dixon AM, Stanley BJ, Matthews EE, Dawson JP, Engelman DM. Biochemistry. 2006 Apr 25. PMID: 16618111.
• Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix.Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM. Proc Natl Acad Sci U S A. 2006 Apr 25; 2006 Apr 11. PMID: 16608910.
• Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions.Miyauchi K, Curran R, Matthews E, Komano J, Hoshino T, Engelman DM, Matsuda Z. Jpn J Infect Dis. 2006 Apr. PMID: 16632906.
• Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function.Sachs JN, Engelman DM. Annu Rev Biochem. 2006. PMID: 16756508.
• Membranes are more mosaic than fluid.Engelman DM. Nature. 2005 Dec 1. PMID: 16319876.
• Transmembrane homodimerization of receptor-like protein tyrosine phosphatases.Chin CN, Sachs JN, Engelman DM. FEBS Lett. 2005 Jul 4. PMID: 15978577.
• Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.Freeman-Cook LL, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM, Dimaio D. J Mol Biol. 2005 Jan 28. PMID: 15588835.
• Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions.Schneider D, Engelman DM. J Mol Biol. 2004 Oct 29. PMID: 15476801.
• Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices.Braun R, Engelman DM, Schulten K. Biophys J. 2004 Aug. PMID: 15298884.
• Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor.Freeman-Cook LL, Dixon AM, Frank JB, Xia Y, Ely L, Gerstein M, Engelman DM, DiMaio D. J Mol Biol. 2004 May 14. PMID: 15111056.
• Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions.Lehnert U, Xia Y, Royce TE, Goh CS, Liu Y, Senes A, Yu H, Zhang ZL, Engelman DM, Gerstein M. Q Rev Biophys. 2004 May. PMID: 15999419.
• The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication.Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie JU, Deber CM. J Biol Chem. 2004 Apr 16; 2004 Feb 5. PMID: 14766751.
• Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol.Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G, Engelman DM. Proc Natl Acad Sci U S A. 2004 Mar 23; 2004 Mar 11. PMID: 15016920.
• Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins.Schneider D, Engelman DM. J Biol Chem. 2004 Mar 12; 2003 Dec 16. PMID: 14681217.
• Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.Liu Y, Gerstein M, Engelman DM. Proc Natl Acad Sci U S A. 2004 Mar 9; 2004 Mar 1. PMID: 14993608.
• Membrane protein folding: beyond the two stage model.Engelman DM, Chen Y, Chin CN, Curran AR, Dixon AM, Dupuy AD, Lee AS, Lehnert U, Matthews EE, Reshetnyak YK, Senes A, Popot JL. FEBS Lett. 2003 Nov 27. PMID: 14630331.
• Effect of detergents on the association of the glycophorin a transmembrane helix.Fisher LE, Engelman DM, Sturgis JN. Biophys J. 2003 Nov. PMID: 14581210.
• The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins.Constantinescu SN, Keren T, Russ WP, Ubarretxena-Belandia I, Malka Y, Kubatzky KF, Engelman DM, Lodish HF, Henis YI. J Biol Chem. 2003 Oct 31; 2003 Aug 20. PMID: 12930840.
• Amphipols: polymeric surfactants for membrane biology research.Popot JL, Berry EA, Charvolin D, Creuzenet C, Ebel C, Engelman DM, Flötenmeyer M, Giusti F, Gohon Y, Hong Q, Lakey JH, Leonard K, Shuman HA, Timmins P, Warschawski DE, Zito F, Zoonens M, Pucci B, Tribet C. Cell Mol Life Sci. 2003 Aug. PMID: 14513831.
• Sequence motifs, polar interactions and conformational changes in helical membrane proteins.Curran AR, Engelman DM. Curr Opin Struct Biol. 2003 Aug. PMID: 12948770.
• Sequence context strongly modulates association of polar residues in transmembrane helices.Dawson JP, Melnyk RA, Deber CM, Engelman DM. J Mol Biol. 2003 Aug 1. PMID: 12875850.
• GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane.Schneider D, Engelman DM. J Biol Chem. 2003 Jan 31; 2002 Nov 21. PMID: 12446730.
• Electrostatic fasteners hold the T cell receptor-CD3 complex together.Engelman DM. Mol Cell. 2003 Jan. PMID: 12535514.
• Mutational analysis of synaptobrevin transmembrane domain oligomerization.Bowen ME, Engelman DM, Brunger AT. Biochemistry. 2002 Dec 31. PMID: 12501216.
• Thermostability of membrane protein helix-helix interaction elucidated by statistical analysis.Schneider D, Liu Y, Gerstein M, Engelman DM. FEBS Lett. 2002 Dec 4. PMID: 12459496.
• Genomic analysis of membrane protein families: abundance and conserved motifs.Liu Y, Engelman DM, Gerstein M. Genome Biol. 2002 Sep 19; 2002 Sep 19. PMID: 12372142.
• Rational design of 'water-soluble' bacteriorhodopsin variants.Mitra K, Steitz TA, Engelman DM. Protein Eng. 2002 Jun. PMID: 12082167.
• Motifs of serine and threonine can drive association of transmembrane helices.Dawson JP, Weinger JS, Engelman DM. J Mol Biol. 2002 Feb 22. PMID: 11866532.