Colorectal Cancer and Women
Colon cancer has been undergoing a similar subdivision. Researchers have known for years that colorectal cancer is the third most common cancer diagnosis in the United States and the second leading cause of cancer-related deaths. The National Cancer Institute estimates 149,500 new cases in 2021 and 53,000 deaths.
Sex-specific Immune Response in COVID-19 Linked to Cellular Metabolism
Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention.Source: Yale News
Caroline Johnson Receives American Cancer Society Research Scholar Grant
Caroline Johnson, Ph.D., Assistant Professor of Epidemiology in the Department of Environmental Health Sciences at Yale School of Public Health and a member of Yale Cancer Center’s Cancer Microbiology Research Program, has received a four-year, $792,000 Research Scholar Grant from the American Cancer Society (ACS).
Better Science, Better Lives: Women's Health Research at Yale is Working for You
Across the country, it’s becoming clearer every day: We must study the health of women. We must study the influence of sex-and-gender differences on health. And it’s time for all aspects of medical research and practice to embrace this change.
Breaking it Down: How the Chemistry of Digestion is Uncovering Sex-Specific Causes of Colon Cancer
A new technology called metabolomics allows researchers to explore the small chemicals formed and used during digestion as a window into the formation of diseases such as colon cancer, seeking early warning signs and potent tactics for prevention.
Metabolomics and the Exposotype: Linking genes and environment to human health
Through the combination of genomics and metabolomics research, scientists are getting closer to understanding the impact of environmental exposure and lifestyle on disease onset. This recently designated "exposotype" (which takes into account genomic and metabolic data) is a new tool researchers can potentially use to refine and revolutionize current thinking about precision medicine and risk assessment.Source: BMC Blog Network
Yale School of Public Health symposium on lifetime exposures and human health: the exposome; summary and future reflections
The exposome is defined as “the totality of environmental exposures encountered from birth to death” and was developed to address the need for comprehensive environmental exposure assessment to better understand disease etiology.Source: Human Genomics
Expansion of metabolomics tools to examine the exposome
In our recent publication, we demonstrate the utility of a metabolomics exposure assessment workflow to aid in the analysis of the exposome. The exposome, first proposed in 2005 as the totality of environmental exposures encountered from birth to death, was conceived to address the pressing need for innovative methodological developments in exposure assessment, to better understand the link between causality and disease. It is a highly interdisciplinary approach which requires biomonitoring for a vast variety of external and internal exposures, assessments of biological response, and bioinformatics to integrate and analyze the different kinds of datasets.Source: MetaboNEWS
Digestion Could Account for Differences in Colon Cancer Among Men, Women
Although women are less likely to develop colon cancer than men, they have higher rates of right-sided colon cancer, which is linked to worse outcomes since it is close in proximity to the small intestine. Colorectal cancer results in more than 50,000 people each year, and is a leading cause of death for both sexes. While this cancer is avoidable through a healthy diet, many Americans develop this cancer each year. A new study being conducted by the Yale Cancer Center suggests that digestion differences could result in sex disparities for colon cancer, according to a press release.Source: Specialty Pharmacy Times
Can Digestive Chemistry Uncover Sex-Specific Causes of Colon Cancer?
Dr. Caroline Helen Johnson received this year’s Wendy U. and Thomas C. Naratil Pioneer Award and co-funding from the Yale Cancer Center to explore hormones and environmental factors related to metabolite production (such as sugars and amino acids) and beneficial bacteria that live in the colon as possible sources of gender difference.
Women’s Health Research at Yale funds studies on colon cancer, infections in pregnancy, and domestic violence
“Through our competitive peer review process, these three studies stood out as extremely promising opportunities to improve and even save lives,” said Dr. Carolyn M. Mazure, director of WHRY. “With these new grants, we continue to expand a broad scope of existing work to focus on questions vital to the health and well-being of millions of women, men, and children.”
MetaboInterview with Caroline Johnson
This section features interviews with prominent researchers in the field of metabolomics. The aim of these interviews is to shed light on metabolomics researchers around the world and give them an opportunity to share their metabolomics story. In this issue, we feature an interview with Caroline H. Johnson.Source: Metabolomics Society News
The Promise and Future of Metabolomics in Public Health - A Q&A with Dr. Caroline Johnson
Caroline H. Johnson, Ph.D., an assistant professor in the Department of Environmental Health Sciences, joined the Yale School of Public Health in the summer of 2016. Her research uses mass spectrometry-based metabolomics to understand the role of metabolites (small molecules produced during metabolism) in human health.
Development and Validation of the Psychiatric Inpatient Experience (PIX) Survey: A Novel Measure of Patient Experience Quality Improvement
David Klemanski, PsyD, MPH, assistant professor of psychiatry, recently published a paper about a new survey he created alongside colleagues Todd Barnes and Cynthia Bautista to measure patient experience for inpatient psychiatry. The measure itself is part of a larger project of patient experience measures within Psychiatry and Behavioral Health.Source: Journal of Patient Experience