2017
Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics
Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH. Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics. Current Pharmacology Reports 2017, 3: 114-125. PMID: 28642837, PMCID: PMC5475285, DOI: 10.1007/s40495-017-0088-z.Peer-Reviewed Original ResearchColorectal cancerRisk of CRCPurpose of ReviewInGerm-line mutationsCRC casesCRC developmentExcessive alcoholMultifaceted etiologyPersonalized therapeutic interventionsTherapeutic interventionsSummaryThis reviewDietary metabolitesEtiologyHost metabolismEnvironmental exposuresGenetic polymorphismsCancerExposure eventsPrevailing majorityExposureAlcohol metabolic pathwayMetabolomicsCurrent understandingMetabolic pathwaysMicrobiome
2016
Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and Microbiome Interplay in Cancer Immunotherapy. Cancer Research 2016, 76: 6146-6152. PMID: 27729325, PMCID: PMC5093024, DOI: 10.1158/0008-5472.can-16-0309.Peer-Reviewed Original ResearchConceptsMicrobial interactionsRole of metabolitesCancer metabolismColon cancerHost microbiomeBiological originCancer progressionAdenoma/carcinomaPolysaccharide matrixTherapeutic designMetabolomic analysisPotential modulatorsMechanism of actionMicrobiomePolyamine metabolitesCancer immunotherapyBacteriaProximal colonBiofilmsProtective biofilmRecent studiesCancer treatmentMetabolismFuture targetsMetabolites