2015
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O’Brien P, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature Communications 2015, 6: 5998. PMID: 25601659, PMCID: PMC4454288, DOI: 10.1038/ncomms6998.Peer-Reviewed Original ResearchConceptsF-AuNPsNon-polar moleculesTeflon-like coatingDesorption/ionizationFluorinated nanoparticlesGold nanoparticlesMass spectrometry imagingAnalyte desorptionRemarkable biocompatibilityMass spectrometry analysisElectron microscopyUnique propertiesMass spectrometryMultimodal imagingNanoparticlesContrast agentsSpectrometry imagingSpectrometry analysisFluorocarbonSynthetic bloodFluorocarbon liquidAuNPsLiquidNanostructuresBiocompatibility
2014
Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling
Benton HP, Ivanisevic J, Mahieu NG, Kurczy ME, Johnson CH, Franco L, Rinehart D, Valentine E, Gowda H, Ubhi BK, Tautenhahn R, Gieschen A, Fields MW, Patti GJ, Siuzdak G. Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling. Analytical Chemistry 2014, 87: 884-891. PMID: 25496351, PMCID: PMC4303330, DOI: 10.1021/ac5025649.Peer-Reviewed Original ResearchConceptsMass spectrometry data acquisitionSystems biology levelMass spectrometry analysisBioinformatics resourcesGlobal profilingTandem mass spectrometry dataProfiling datasetsMass spectrometry databaseMass spectrometry dataSpectrometry analysisProfilingData acquisitionSpectrometry dataRapid metabolite identificationMetabolomic profilingUntargeted metabolomicsBacterial samplesMetabolomicsSimultaneous data processingIdentificationMetabolite identificationMetabolomics workflowsFliesAutomatic searchAutonomous approach