Publications

• Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT.Ong Q, Lim LTR, Goh C, Liao Y, Chan SE, Lim CJY, Kam V, Yap J, Tseng T, Desrouleaux R, Wang LC, Ler SG, Lim SL, Kim SY, Sobota RM, Bennett AM, Han W, Yang X. Nat Chem Biol. 2025 Feb; 2024 Nov 14. PMID: 39543398.
• Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway.Dorry S, Perla S, Bennett AM. Mol Cell Biol. 2025 Jan; 2024 Nov 28. PMID: 39607740.
• Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics.Bennett AM, Tiganis T. Annu Rev Physiol. 2024 Nov 12; 2024 Nov 12. PMID: 39531392.
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP. bioRxiv. 2024 Sep 5; 2024 Sep 5. PMID: 39282375.
• miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression.Fernández-Tussy P, Cardelo MP, Zhang H, Sun J, Price NL, Boutagy NE, Goedeke L, Cadena-Sandoval M, Xirouchaki CE, Brown W, Yang X, Pastor-Rojo O, Haeusler RA, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. JCI Insight. 2024 Aug 27; 2024 Aug 27. PMID: 39190492.
• MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway.Dorry S, Perla S, Bennett AM. bioRxiv. 2024 Jun 27; 2024 Jun 27. PMID: 38979264.
• Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y. Diabetologia. 2024 Apr; 2024 Jan 13. PMID: 38216792.
• The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy.Pierpont EI, Bennett AM, Schoyer L, Stronach B, Anschutz A, Borrie SC, Briggs B, Burkitt-Wright E, Castel P, Cirstea IC, Draaisma F, Ellis M, Fear VS, Frone MN, Flex E, Gelb BD, Green T, Gripp KW, Khoshkhoo S, Kieran MW, Kleemann K, Klein-Tasman BP, Kontaridis MI, Kruszka P, Leoni C, Liu CZ, Merchant N, Magoulas PL, Moertel C, Prada CE, Rauen KA, Roelofs R, Rossignol R, Sevilla C, Sevilla G, Sheedy R, Stieglitz E, Sun D, Tiemens D, White F, Wingbermühle E, Wolf C, Zenker M, Andelfinger G. Am J Med Genet A. 2024 Apr; 2023 Nov 15. PMID: 37969032.
• MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution.Fortier SM, Walker NM, Penke LR, Baas JD, Shen Q, Speth JM, Huang SK, Zemans RL, Bennett AM, Peters-Golden M. J Clin Invest. 2024 Mar 21; 2024 Mar 21. PMID: 38512415.
• Identification of Protein Tyrosine Phosphatase (PTP) Substrates.Perla S, Qiu B, Dorry S, Yi JS, Bennett AM. Methods Mol Biol. 2024. PMID: 38147212.
• An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies.Yi JS, Perla S, Bennett AM. Cardiovasc Drugs Ther. 2023 Dec; 2022 Feb 14. PMID: 35156148.
• MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. Nat Commun. 2023 Sep 5; 2023 Sep 5. PMID: 37669951.
• MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. bioRxiv. 2023 Jul 11; 2023 Jul 11. PMID: 37502892.
• Teaching an old dog new tricks: A new tool for protein tyrosine phosphatase substrate discovery.Bennett AM. J Biol Chem. 2023 May; 2023 Apr 18. PMID: 37080392.
• SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.Karampitsakos T, Galaris A, Barbayianni I, DeIuliis G, Ahangari F, Sampsonas F, Sotiropoulou V, Aidinis V, Bennett AM, Herazo-Maya JD, Xylourgidis N, Bakakos P, Bouros D, Kaminski N, Tzouvelekis A. Diagnostics (Basel). 2023 Mar 18; 2023 Mar 18. PMID: 36980473.
• Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression.Fernández-Tussy P, Sun J, Cardelo MP, Price NL, Goedeke L, Xirouchaki CE, Yang X, Pastor-Rojo O, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. bioRxiv. 2023 Jan 20; 2023 Jan 20. PMID: 36711578.
• Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?Shillingford SR, Bennett AM. Annu Rev Pharmacol Toxicol. 2023 Jan 20. PMID: 36662585.
• Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Eur J Med Chem. 2022 Dec 5; 2022 Sep 2. PMID: 36116232.
• A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM. J Biol Chem. 2022 Dec; 2022 Oct 19. PMID: 36272649.
• Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines.Yi JS, Perla S, Huang Y, Mizuno K, Giordano FJ, Vinks AA, Bennett AM. Cardiovasc Drugs Ther. 2022 Aug; 2021 Mar 10. PMID: 33689087.
• The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery.Kontaridis MI, Roberts AE, Schill L, Schoyer L, Stronach B, Andelfinger G, Aoki Y, Axelrad ME, Bakker A, Bennett AM, Broniscer A, Castel P, Chang CA, Cyganek L, Das TK, den Hertog J, Galperin E, Garg S, Gelb BD, Gordon K, Green T, Gripp KW, Itkin M, Kiuru M, Korf BR, Livingstone JR, López-Juárez A, Magoulas PL, Mansour S, Milner T, Parker E, Pierpont EI, Plouffe K, Rauen KA, Shankar SP, Smith SB, Stevenson DA, Tartaglia M, Van R, Wagner ME, Ware SM, Zenker M. Am J Med Genet A. 2022 Jun; 2022 Mar 9. PMID: 35266292.
• MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis.Zhong C, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. Front Immunol. 2021; 2021 Dec 21. PMID: 34992607.
• An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. Sci Signal. 2020 Aug 25; 2020 Aug 25. PMID: 32843541.
• Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.Yi JS, Perla S, Enyenihi L, Bennett AM. JCI Insight. 2020 Aug 6; 2020 Aug 6. PMID: 32584792.
• The sixth international RASopathies symposium: Precision medicine-From promise to practice.Gripp KW, Schill L, Schoyer L, Stronach B, Bennett AM, Blaser S, Brown A, Burdine R, Burkitt-Wright E, Castel P, Darilek S, Dias A, Dyer T, Ellis M, Erickson G, Gelb BD, Green T, Gross A, Ho A, Holder JL Jr, Inoue SI, Jelin AC, Kennedy A, Klein R, Kontaridis MI, Magoulas P, McConnell DB, McCormick F, Neel BG, Prada CE, Rauen KA, Roberts A, Rodriguez-Viciana P, Rosen N, Rumbaugh G, Sablina A, Solman M, Tartaglia M, Thomas A, Timmer WC, Venkatachalam K, Walsh KS, Wolters PL, Yi JS, Zenker M, Ratner N. Am J Med Genet A. 2020 Mar; 2019 Dec 11. PMID: 31825160.
• Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1.Bennett AM, Lawan A. J Cell Signal. 2020. PMID: 33179019.
• O-GlcNAc transferase suppresses necroptosis and liver fibrosis.Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.
• Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.Xylourgidis N, Min K, Ahangari F, Yu G, Herazo-Maya JD, Karampitsakos T, Aidinis V, Binzenhöfer L, Bouros D, Bennett AM, Kaminski N, Tzouvelekis A. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1; 2019 Sep 4. PMID: 31483681.
• Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.Levy AD, Xiao X, Shaw JE, Sudarsana Devi SP, Katrancha SM, Bennett AM, Greer CA, Howe JR, Machida K, Koleske AJ. Cell Rep. 2018 Aug 7. PMID: 30089263.
• DUSPs, twists and turns in the Journey to Vascular Inflammation.Bennett AM. FEBS J. 2018 May; 2018 Apr 22. PMID: 29682902.
• Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM. Diabetes. 2018 Apr; 2018 Jan 9. PMID: 29317435.
• Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism.Lawan A, Bennett AM. Trends Endocrinol Metab. 2017 Dec; 2017 Nov 8. PMID: 29128158.
• Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis.Min K, Lawan A, Bennett AM. Skelet Muscle. 2017 Oct 18; 2017 Oct 18. PMID: 29047406.
• Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation.Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. Genes Dev. 2017 Aug 15; 2017 Sep 13. PMID: 28903979.
• A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis.Lee H, Min K, Yi JS, Shi H, Chang W, Jackson L, Bennett AM. J Biol Chem. 2017 Mar 3; 2017 Jan 17. PMID: 28096466.
• SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis.Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. Am J Respir Crit Care Med. 2017 Feb 15. PMID: 27736153.
• Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.
• Low-dose dasatinib rescues cardiac function in Noonan syndrome.Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM. JCI Insight. 2016 Dec 8; 2016 Dec 8. PMID: 27942593.
• Mice lacking MKP-1 and MKP-5 Reveal Hierarchical Regulation of Regenerative Myogenesis.Shi H, Gatzke F, Molle JM, Lee HB, Helm ET, Oldham JJ, Zhang L, Gerrard DE, Bennett AM. J Stem Cell Regen Biol. 2015 Nov 12. PMID: 27064463.
• Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen.Lee H, Bennett AM. Methods Mol Biol. 2015. PMID: 25319894.
• Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Mol Cell Biol. 2015 Jan; 2014 Oct 13. PMID: 25312648.
• Mining the function of protein tyrosine phosphatases in health and disease.Lee H, Yi JS, Lawan A, Min K, Bennett AM. Semin Cell Dev Biol. 2015 Jan; 2014 Sep 26. PMID: 25263013.
• Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Am J Physiol Endocrinol Metab. 2014 Dec 1; 2014 Oct 14. PMID: 25315698.
• PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.Paardekooper Overman J, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J, Bennett AM. Mol Cell Biol. 2014 Aug; 2014 May 27. PMID: 24865967.
• The imprinted H19 lncRNA antagonizes let-7 microRNAs.Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. Mol Cell. 2013 Oct 10; 2013 Sep 19. PMID: 24055342.
• Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5.Shi H, Verma M, Zhang L, Dong C, Flavell RA, Bennett AM. J Clin Invest. 2013 May; 2013 Apr 1. PMID: 23543058.
• Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.Lee H, Bennett AM. Mol Cell Biol. 2013 Apr; 2013 Jan 28. PMID: 23358419.
• Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.Mercan F, Lee H, Kolli S, Bennett AM. Mol Cell Biol. 2013 Jan; 2012 Nov 5. PMID: 23129808.
• Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions.Lawan A, Shi H, Gatzke F, Bennett AM. Cell Mol Life Sci. 2013 Jan; 2012 Jun 14. PMID: 22695679.
• The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL, van Buul JD. Mol Biol Cell. 2012 Nov; 2012 Sep 5. PMID: 22956765.
• O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR 3rd, Yang X. Cell Metab. 2012 Aug 8. PMID: 22883232.
• Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity.Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. Nat Med. 2011 Aug 28; 2011 Aug 28. PMID: 21873987.
• Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27.Flach RJ, Qin H, Zhang L, Bennett AM. J Biol Chem. 2011 Jun 24; 2011 Apr 26. PMID: 21521693.
• Mitogen-activated protein kinase phosphatase-1 - a potential therapeutic target in metabolic disease.Roth Flach RJ, Bennett AM. Expert Opin Ther Targets. 2010 Dec. PMID: 21058921.
• The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching.Jeanneteau F, Deinhardt K, Miyoshi G, Bennett AM, Chao MV. Nat Neurosci. 2010 Nov; 2010 Oct 10. PMID: 20935641.
• MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy.Shi H, Boadu E, Mercan F, Le AM, Flach RJ, Zhang L, Tyner KJ, Olwin BB, Bennett AM. FASEB J. 2010 Aug; 2010 Apr 6. PMID: 20371627.
• Analysis of protein tyrosine phosphatases and substrates.Mercan F, Bennett AM. Curr Protoc Mol Biol. 2010 Jul. PMID: 20583096.
• MAP kinase phosphatase-1--a new player at the nexus between sarcopenia and metabolic disease.Flach RJ, Bennett AM. Aging (Albany NY). 2010 Apr 6; 2010 Apr 6. PMID: 20375469.
• MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. J Clin Invest. 2009 Dec; 2009 Nov 16. PMID: 19920356.
• Physiological signaling specificity by protein tyrosine phosphatases.Soulsby M, Bennett AM. Physiology (Bethesda). 2009 Oct. PMID: 19815854.
• Role of MKP-1 in osteoclasts and bone homeostasis.Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A. Am J Pathol. 2009 Oct; 2009 Sep 17. PMID: 19762714.
• JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM, Chen H. J Biol Chem. 2009 May 15; 2009 Mar 13. PMID: 19287004.
• Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.Eminaga S, Bennett AM. J Biol Chem. 2008 May 30; 2008 Mar 31. PMID: 18378677.
• A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor.Ha CH, Bennett AM, Jin ZG. J Biol Chem. 2008 Mar 14; 2008 Jan 7. PMID: 18180305.
• c-Met must translocate to the nucleus to initiate calcium signals.Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. J Biol Chem. 2008 Feb 15; 2007 Dec 11. PMID: 18073207.
• Nucleoplasmic calcium is required for cell proliferation.Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, Nathanson MH. J Biol Chem. 2007 Jun 8; 2007 Apr 9. PMID: 17420246.
• SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway.Zito CI, Qin H, Blenis J, Bennett AM. J Biol Chem. 2007 Mar 9; 2007 Jan 17. PMID: 17229738.
• Protein tyrosine phosphatase function: the substrate perspective.Tiganis T, Bennett AM. Biochem J. 2007 Feb 15. PMID: 17238862.
• SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth.Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG, Bennett AM. J Cell Biol. 2006 Oct 9; 2006 Oct 2. PMID: 17015617.
• Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.Wu JJ, Roth RJ, Anderson EJ, Hong EG, Lee MK, Choi CS, Neufer PD, Shulman GI, Kim JK, Bennett AM. Cell Metab. 2006 Jul. PMID: 16814733.
• Calcium signaling in the nucleus.Gomes DA, Leite MF, Bennett AM, Nathanson MH. Can J Physiol Pharmacol. 2006 Mar-Apr. PMID: 16902580.
• Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Proc Natl Acad Sci U S A. 2006 Feb 14; 2006 Feb 6. PMID: 16461893.
• Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Proc Natl Acad Sci U S A. 2006 Feb 14; 2006 Feb 3. PMID: 16461457.
• Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver.Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK. Diabetes. 2005 Sep. PMID: 16123338.
• The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation.Wu JJ, Zhang L, Bennett AM. Mol Cell Biol. 2005 Jun. PMID: 15899879.
• Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling.Wu JJ, Bennett AM. J Biol Chem. 2005 Apr 22; 2005 Feb 17. PMID: 15722358.
• Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus.Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hiesberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ. J Clin Invest. 2004 Nov. PMID: 15545994.
• The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM. J Biol Chem. 2004 Jul 9; 2004 May 7. PMID: 15133037.
• SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.Kontaridis MI, Eminaga S, Fornaro M, Zito CI, Sordella R, Settleman J, Bennett AM. Mol Cell Biol. 2004 Jun. PMID: 15169898.
• SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis.Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM. J Cell Physiol. 2004 May. PMID: 15040005.
• Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium.Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. J Biol Chem. 2002 Jul 26; 2002 Apr 23. PMID: 11971908.
• Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts.Kontaridis MI, Liu X, Zhang L, Bennett AM. Mol Cell Biol. 2002 Jun. PMID: 11997521.