Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence
Thomas JC, Figueira M, Fennie KP, Laufer AS, Kong Y, Pichichero ME, Pelton SI, Pettigrew MM. Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence. PLOS ONE 2011, 6: e18649. PMID: 21533186, PMCID: PMC3077395, DOI: 10.1371/journal.pone.0018649.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChinchillaDisease Models, AnimalGenes, BacterialGenetic VariationPneumococcal InfectionsStreptococcus pneumoniaeVirulenceConceptsChinchilla modelHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineSerotype 19A isolatesMiddle ear isolatesS. pneumoniae isolatesLong-term effectivenessConjugate vaccinePneumococcal diseaseOtitis mediaVaccinated populationReplacement diseaseBlood isolatesInvasive diseaseCarriage isolatesPneumoniae isolatesCerebrospinal fluidEar isolatesFuture vaccinesImportant causeStreptococcus pneumoniaeMiddle earDiseaseVirulence potentialVaccine