2025
Decreased locus coeruleus multiunit activity in a mouse model of temporal lobe seizures with impaired consciousness
Valcarce-Aspegren M, Paszkowski P, Liu S, Wu Q, McGill S, Sieu L, Blumenfeld H. Decreased locus coeruleus multiunit activity in a mouse model of temporal lobe seizures with impaired consciousness. Experimental Neurology 2025, 389: 115233. PMID: 40189126, PMCID: PMC12083539, DOI: 10.1016/j.expneurol.2025.115233.Peer-Reviewed Original ResearchConceptsLocus coeruleusFocal limbic seizuresLimbic seizuresRight orbitofrontal cortexFiring of LC neuronsBasal forebrain cholinergic neuronsForebrain cholinergic neuronsAwake mouse modelHead-fixed miceOrbitofrontal cortexDorsal hippocampiImpaired consciousnessMouse modelTemporal lobe epilepsyCortical impairmentLC neuronsNoradrenergic pathwaysRecording multiunit activitySubcortical pathwaysMultiunit activityCholinergic neuronsTemporal lobe seizuresPeriod of impaired consciousnessRodent modelsLobe epilepsy
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBrain WavesCerebral CortexElectrodes, ImplantedFemaleNeuronsRatsRats, Sprague-DawleySeizuresConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system
1990
Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons
Blumenfeld H, Spiral M, Kandel E, Siegelbaum S. Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons. Neuron 1990, 5: 487-499. PMID: 1976321, DOI: 10.1016/0896-6273(90)90088-w.Peer-Reviewed Original ResearchConceptsAplysia sensory neuronsAction potentialsSensory neuronsIndicator dye fura-2Sensory neuron terminalsDye fura-2Modulation of Ca2Presynaptic inhibitionInhibitory transmitterNeuron terminalsPresynaptic facilitationCalcium influxFura-2Intracellular injectionIntracellular Ca2Transient riseInternal Ca2Time courseNeuronsFMRFamideCa2InfluxSerotonin
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