Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVanessa Scanlon, PhD
Assistant Professor AdjunctDownloadHi-Res Photo
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Assistant Professor Adjunct
Biography
Vanessa Scanlon is an Assistant Professor at the University of Connecticut. She is passionate about science and strengthening the pipeline of underrepresented individuals to successful research careers. Her research interests include hematopoiesis and the bone marrow microenvironment. In her spare time, she enjoys live music, gardening and star gazing.
Last Updated on January 02, 2024.
Appointments
Laboratory Medicine
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- UConn Health, Biomedical Science (2015)
- BS
- UConn, MCB (2006)
- BS
- UConn, DGS (2006)
Research
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Overview
Currently, I work on understanding extrinsic mechanisms that underly hematopoietic progenitor cell fate decisions. I have developed a novel method for time-lapse microscopy of bipotent progenitors dividing and committing to two potential lineages. I'm also interested in developing 3D engineered in vitro cell culture models to further investigate spatial regulation between cells of the bone marrow microenvironment.
I also study the function of specific domains within a co-transcriptional activator during megakaryocytopoiesis.
Medical Research Interests
Blood Cells; Hematopoietic System
ORCID
0000-0002-5569-6901
Research at a Glance
Yale Co-Authors
Frequent collaborators of Vanessa Scanlon's published research.
Publications Timeline
A big-picture view of Vanessa Scanlon's research output by year.
Diane Krause, MD, PhD
Madeline Mayday
Lin Wang, MS
Betty R. Lawton, PhD
Karin Finberg, MD, PhD
Max Carlino
25Publications
235Citations
Publications
Featured Publications
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocytic-erythroid progenitorsFate specificationLineage commitmentUnderstanding of hematopoiesisProgenitor cell biologyPrimary human hematopoietic progenitorsSingle-cell trackingSingle-cell assaysSingle-cell levelHuman hematopoietic progenitorsProgenitor cell dynamicsLineage specificationCell fateColony-forming unit assaysTimelapse imagingSitu fluorescence stainingCell biologyLineage tracingDivision rateCytokine thrombopoietinHematopoietic progenitorsProgenitorsFluorescence stainingCell dynamicsUnit assays
2025
β-adrenergic signaling alters the transcriptome of erythroid precursor cells and erythropoietic differentiation 4069
Chawla A, Hagymasi A, Sun H, Gunturu S, Sinha S, Mandoiu I, Geyer R, Scanlon V, Srivastava P, Nevin J. β-adrenergic signaling alters the transcriptome of erythroid precursor cells and erythropoietic differentiation 4069. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1799.Peer-Reviewed Original ResearchConceptsErythroid precursor cellsErythroid differentiationPrecursor cellsB2 adrenergic receptorGroups of miceRegulation of erythroid differentiationSympathetic nervous systemMature red blood cellsTerminal erythroid differentiationImmune suppressionTumor-bearingNeuroimmune interactionsTranscriptional profilesTreated miceRed blood cellsErythroid precursorsImmature erythroblastsAdrenergic blockadeRestraint stressSingle cell RNA sequencingAdrenergic stimulationDysregulated erythropoiesisCell RNA sequencingErythropoietic differentiationErythropoiesis3215 – ADRENERGIC STRESS MISDIRECTS ERYTHROPOIESIS COMPROMISING CANCER IMMUNITY
Chawla A, Geyer R, Gunturu S, Hagymasi A, Mandoiu I, Nevin J, Scanlon V, Sinha S, Srivastava P, Sun H. 3215 – ADRENERGIC STRESS MISDIRECTS ERYTHROPOIESIS COMPROMISING CANCER IMMUNITY. Experimental Hematology 2025, 151: 105156. DOI: 10.1016/j.exphem.2025.105156.Peer-Reviewed Original ResearchConceptsErythroid precursor cellsSympathetic nervous systemAntigen-specific CD8+ T cell responsesCD8+ T cell responsesAdrenergic signalingT cell responsesHistocompatibility complex class IMajor histocompatibility complex class IHuman hematopoietic systemB2 adrenergic receptorImmune cell functionAntitumor immunityCancer immunityDendritic cellsLymphoid lineagesAdrenergic stressErythroid precursorsTumor progressionImmunosuppressive effectsHematopoietic systemImmune modulationAllogeneic rejectionImmune regulationErythroid cellsClass IBuilding a transparent and functional laboratory culture: guidelines for creating a Laboratory Handbook for principal investigators
de Bock C, Bridge K, van Gastel N, Gleitz H, Kats L, King K, Machlus K, Psaila B, Scanlon V, Souroullas G, Kokkaliaris K. Building a transparent and functional laboratory culture: guidelines for creating a Laboratory Handbook for principal investigators. Experimental Hematology 2025, 151: 105265. PMID: 40976536, DOI: 10.1016/j.exphem.2025.105265.Peer-Reviewed Original ResearchAltmetricQuantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming
Favaro P, Glass D, Borges L, Baskar R, Lam A, Reynolds W, Ho D, Bruce T, Tebaykin D, Koehnke T, Scanlon V, Shestopalov I, Bendall S. Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming. Cell Reports 2025, 44: 115913. PMID: 40577131, DOI: 10.1016/j.celrep.2025.115913.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHSPC subsetsCD34- cellsIntrinsic regulatory factorsCord bloodFetal liverHematopoietic stemPeripheral bloodMyeloid lineageHematological conditionsBone marrowProspective isolationEssential therapyProgenitor cellsHematopoietic tissueDifferentiation assaysHematopoietic modelLineage primingEpigenetic analysisHSPCsCross-tissueCross-tissue comparisonSurface proteinsRegulatory factorsBloodFunctional regulationProteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Tanguay A, Menon N, Slavin E, Moody M, McEwen E, Jay G, Lorenzo J, Bartley J, Scanlon V, Deymier A, Schmidt T. Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging. GeroScience 2025, 1-14. PMID: 40537697, DOI: 10.1007/s11357-025-01747-x.Peer-Reviewed Original ResearchAltmetricConceptsWT miceCamptodactyly-arthropathy-coxa vara-pericarditisProteoglycan 4Aged wild typeYoung WT miceComplete blood countLoss-of-function mutationsAssessed clinical relevanceProteoglycan 4 geneBlood countAged miceSerum concentrationsAnti-fibroticRare diseaseBlood gasesClinical relevanceImmunomodulatory propertiesMiceWild typeBlood parametersYounger ageSurvival probabilitySex-dependentSerumLower survival probability
2024
3109 – OPTIMIZING AND SIMPLIFYING READOUT OF HEMATOPOIETIC COLONY FORMING UNIT (CFU) ASSAYS
Krause D, Thompson E, Carlino M, Scanlon V. 3109 – OPTIMIZING AND SIMPLIFYING READOUT OF HEMATOPOIETIC COLONY FORMING UNIT (CFU) ASSAYS. Experimental Hematology 2024, 137: 104431. DOI: 10.1016/j.exphem.2024.104431.Peer-Reviewed Original ResearchConceptsColony forming unitsCell typesProportion of coloniesFluorescence Activated Cell SortingColony morphologyForming unitsColony typesIdentification of basophilsLineagesColony forming unit assayCell morphologyCell sortingColoniesIndividual stemsSemisolid mediumMK cellsMultipotent progenitorsDetect GProgenitor populationsLineage potentialCommon myeloid progenitorsCellsIL-3Megakaryocytic lineageCombination of G-CSFβ-adrenergic signaling regulates erythropoiesis and through it; cancer immunity
Chawla A, Hagymasi A, Geyer R, Mandoiu I, Peterson K, Scanlon V, Srivastava P, Nevin J. β-adrenergic signaling regulates erythropoiesis and through it; cancer immunity. The Journal Of Immunology 2024, 212: 0773_5658-0773_5658. DOI: 10.4049/jimmunol.212.supp.0773.5658.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsSympathetic signalingAnti-tumor CD8+ T cell responsesExhaustion of CD8+ T cellsTumor-infiltrating CD8+ T cellsCD8+ T cell responsesRed blood cell poolMyeloid-derived suppressor cellsEmergence of TregsT cell responsesBlood cell poolTumor-bearing miceErythroid precursor cellsSympathetic nervous systemRegulation of hematopoiesisTumor growth in vivoRegulation of erythropoiesisGrowth in vivoSuppressor cellsCancer immunityLymphoid lineagesImmune cellsNeuroimmune communicationErythroid lineage
2023
Assay optimization for the objective quantification of human multilineage colony-forming units
Thompson E, Carlino M, Scanlon V, Grimes H, Krause D. Assay optimization for the objective quantification of human multilineage colony-forming units. Experimental Hematology 2023, 124: 36-44.e3. PMID: 37271449, PMCID: PMC10527702, DOI: 10.1016/j.exphem.2023.05.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFluorescence-activated cell sortingLineage potentialCommon myeloid progenitorsHigh-throughput microscopyMultilineage colony-forming unitsProportion of coloniesSpecific growth factorsCFU assayColony-forming unit assaysMultipotent progenitorsProgenitor populationsLineage outputSitu immunofluorescenceMegakaryocytic lineageMK cellsMegakaryocytic cellsCell typesMyeloid progenitorsProgenitor cellsCell morphologyCell sortingUnit assaysIL-3Colony typesCulture conditionsSATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction
Wilkes M, Chae H, Scanlon V, Cepika A, Wentworth E, Saxena M, Eskin A, Chen Z, Glader B, Roncarolo M, Nelson S, Sakamoto K. SATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction. Stem Cells 2023, 41: 560-569. PMID: 36987811, PMCID: PMC10267687, DOI: 10.1093/stmcls/sxad025.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocyte/erythroid progenitorsSpecial AT-rich sequence-binding protein 1Diamond-Blackfan anemiaInherited bone marrow failure syndromeChromatin loopsInduction of HSP70Hsp70 geneShock protein 70Progenitor expansionBiological functionsEarly myeloid progenitorsBone marrow failure syndromesErythroid factorsErythroid progenitorsMyeloid progenitorsMarrow failure syndromesProtein 1Protein 70Blackfan anemiaHSP70Specific sitesProgenitorsCell modelSATB1 expressionInduction
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