Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsToma Tebaldi, PhD
Assistant Professor AdjunctDownloadHi-Res Photo
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Titles
Assistant Professor Adjunct
Biography
My research aims at understanding the RNA molecular mechanisms underlying dysregulation in human diseases, by combining experimental and computational approaches and with focus on alternative splicing events, binding of non-coding RNAs and mutant RNA binding proteins, RNA modifications (the epitranscriptome), translation dynamics and single cell expression data.
https://www.researchgate.net/profile/Toma_Tebaldi
https://orcid.org/0000-0002-0625-1631
Last Updated on February 11, 2025.
Appointments
Medical Oncology and Hematology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Genomics, Genetics, and Epigenetics
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
- Yale Cancer Center
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Visiting Professor
- University of Trento (2020)
- Visiting Professor
- University of Trento (2019)
- Postdoctoral fellowship
- University of Trento (2017)
- EMBO Short Fellowship
- University of Edinburgh (2015)
- International Internship
- University of Edinburgh (2013)
- Postdoctoral fellowship
- University of Trento (2013)
- Postdoctoral fellowship
- University of Trento (2012)
- PhD
- University of Trento, Information and Communication Technology (2010)
- International internship
- Harvard Medical School (2009)
- International internship
- University of Sheffield (2009)
- MSc
- University of Milano Bicocca, Biotechnologies - Bioinformatics (2006)
- BSc
- University of Milano Bicocca, Biotechnologies (2003)
Research
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Overview
RNA biology
Medical Research Interests
Computational Biology; Hematologic Neoplasms
ORCID
0000-0002-0625-1631
Research at a Glance
Yale Co-Authors
Frequent collaborators of Toma Tebaldi's published research.
Publications Timeline
A big-picture view of Toma Tebaldi's research output by year.
Research Interests
Research topics Toma Tebaldi is interested in exploring.
Stephanie Halene, MD, Dr Med
Giulia Biancon, PhD
Jennifer VanOudenhove, PhD
Diane Krause, MD, PhD
Emanuela Bruscia, PhD
Marie Egan, MD
32Publications
303Citations
Computational Biology
Publications
2025
Double stranded RNA sensing is silenced during early embryonic development
Witteveldt J, Liu Z, Ariza-Cosano A, Ramirez C, Walters J, Marchante P, Maas L, Friman E, Ivens A, Tebaldi T, Heras S, Marks H, Macias S. Double stranded RNA sensing is silenced during early embryonic development. Nature Communications 2025, 16: 11438. PMID: 41381491, DOI: 10.1038/s41467-025-66352-0.Peer-Reviewed Original ResearchAltmetricConceptsMouse embryonic stem cellsRIG-I-likeDouble stranded RNAEmbryonic stem cellsStranded RNARIG-I-like receptor pathwayGene expression programmesPluripotent mouse embryonic stem cellsStem cellsRNA sensor MDA5Type I interferon responseEarly embryonic developmentExpression programmesMammalian developmentRNA sensingProteomic analysisSensing pathwaysEarly developmentDevelopmental defectsEmbryonic developmentProduction of interferonReceptor pathwayIFN responseMDA5 expressionMDA5Examining the role of U2AF1 and TET2 mutations in a myeloid malignancy mouse model
Cheng M, Kenworthy C, Paul S, Maul-Newby H, VanOudenhove J, Busarello E, Vigorelli M, Tebaldi T, Halene S, Biancon G. Examining the role of U2AF1 and TET2 mutations in a myeloid malignancy mouse model. Blood 2025, 146: 3837-3837. DOI: 10.1182/blood-2025-3837.Peer-Reviewed Original ResearchConceptsLineage-negative cellsComplete blood countMouse modelBone marrowSplicing factorsDM miceU2AF1 mutationsMyeloid malignanciesTET2 mutationsPeripheral bloodMutant cellsCo-mutationsAssociated with poor clinical outcomesStem cell levelHematopoietic stem cellsProgression to AMLInitiation of oncogenesisPoor clinical outcomesTerminal myeloid differentiationWild-typeDM conditionsMalignancy in vivoMutations in vivoEarly consequencesSplicing factor mutationsMETTL3 inhibition disrupts R-loop homeostasis and activates the cgas-sting pathway in Acute Myeloid Leukemia
Yang H, VanOudenhove J, Wei M, Ramirez C, Maul-Newby H, Fedorov E, Conway C, King M, Tothova Z, Ofir-Rosenfeld Y, Tebaldi T, Halene S. METTL3 inhibition disrupts R-loop homeostasis and activates the cgas-sting pathway in Acute Myeloid Leukemia. Blood 2025, 146: 5061-5061. DOI: 10.1182/blood-2025-5061.Peer-Reviewed Original ResearchConceptsDNA-RNA hybridsDNA double-strand breaksGene Set Enrichment AnalysisR-loopsDNA-RNA immunoprecipitationR-loop accumulationYT521-B homologyDown-regulated genesInnate immune responseDNA-RNAAbstract Acute myeloid leukemiaProximity ligation assayCGAS-STING pathwayMOLM13 cellsResolution of R-loopsNuclear export factor CRM1Accumulation of R-loopsR-loop homeostasisR-loop formationExport factor CRM1R-loop dynamicsRNA-seq dataAntiviral innate immune responseCatalytically dead formInsulin-like growth factor 2 mRNA-binding proteinsRBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNACell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease
Busarello E, Biancon G, Cimignolo I, Lauria F, Ibnat Z, Ramirez C, Tomè G, Ciuffreda M, Bucciarelli G, Pilli A, Marino S, Bontempi V, Ress F, Aass K, VanOudenhove J, Tiberi L, Mione M, Standal T, Macchi P, Viero G, Halene S, Tebaldi T. Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease. Nature Communications 2025, 16: 5399. PMID: 40623970, PMCID: PMC12234662, DOI: 10.1038/s41467-025-60900-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSingle-cellBiological interpretationCell typesSingle-cell technologiesIdentification of cell typesMultiple single-cellPhysiological cell typesSingle-cell populationsCellular heterogeneityDisease contextsInconsistent annotationsMurine tissuesWeight markersAnnotationCellsSpatial populationAnnotation accuracyPathological processesAvailable databasesMarkersPotential biomarkersAutomatic annotationPhysiologyUnique opportunityDiseaseComputational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs
Ramirez C, Perenthaler E, Lauria F, Tebaldi T, Viero G. Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs. RNA Biology 2025, 22: 1-11. PMID: 40377202, PMCID: PMC12218551, DOI: 10.1080/15476286.2025.2506712.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsThe efficacy of METTL3 inhibition in pre-clinical models of MDS and AML.
Kenworthy C, Wei M, VanOudenhove J, Busarello E, Ramirez Amarilla C, Paul S, Cruz J, Baassiri A, Maul-Newby H, Biancon G, Tebaldi T, Halene S. The efficacy of METTL3 inhibition in pre-clinical models of MDS and AML. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e18584.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaMyelodysplastic syndromeInnate immune responseImmune signaturesTransplantation modelModel of myelodysplastic syndromeMurine models of leukemiaPreclinical anti-tumour efficacyImmune responseInnate immune cell subsetsSolid tumor clinical trialsSplicing factorsCompetitive transplant modelImmune checkpoint inhibitionMouse solid tumor modelsDouble-stranded RNAMyelodysplastic syndrome patientsInnate immune signaturesAnti-tumor efficacyImmune cell subsetsMyelodysplastic syndromes pathogenesisDriver genesSolid tumor modelsPre-clinical modelsModels of leukemiaImpact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant
VanOudenhove J, Liu Y, Nelakanti R, Kim D, Busarello E, Ovalle N, Qi Z, Mamillapalli P, Siddon A, Bai Z, Axtmayer A, Corso C, Kothari S, Foss F, Isufi I, Tebaldi T, Gowda L, Fan R, Seropian S, Halene S. Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant. PLOS ONE 2025, 20: e0320744. PMID: 40294012, PMCID: PMC12036906, DOI: 10.1371/journal.pone.0320744.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHematopoietic stem cell transplantationMemory T cellsStem cell transplantationCell transplantationT cellsSARS-CoV-2Hematopoietic stem cell transplant recipientsAntigen-specific T-cell activationSARS-CoV-2 mRNA vaccinesSARS-CoV-2 vaccine responsesSevere diseaseAnti-spike IgGT cell activationAdaptive immune responsesRobust antibody responsesPost-vaccination responseSARS-CoV-2 infectionMRNA vaccine seriesSingle-cell RNAMyeloablative chemotherapyCellular responsesImmune profileVaccine responseCOVID-19 infectionMRNA vaccinesAn in vivo screen identifies NAT10 as a master regulator of brain metastasis
Chen J, Xu P, Cai W, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop E, Asare E, Zhang Y, Yin M, Tebaldi T, Meier J, Westbrook T, Halene S, Liu Y, Shen H, Nguyen D, Yan Q. An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Science Advances 2025, 11: eads6021. PMID: 40138393, PMCID: PMC11939035, DOI: 10.1126/sciadv.ads6021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPhosphoserine aminotransferase 1Metastasis in vivoIn vivo screeningRNA helicase domainRegulator of brain metastasisMetastatic breast cancer cellsBrain metastasis in vivoBrain metastasesRNA helicaseCell growth in vitroBreast cancer cellsCancer cell proliferationSerine biosynthesisEpigenetic regulationGrowth in vitroNAT10Migration in vitroCancer cellsTumor growthCell proliferationPrimary tumor growthDrivers of brain metastasesRNACancer metastasisCancer-related deathsDissecting the stress granule RNA world: dynamics, strategies and data
Biancon G, Busarello E, Cheng M, Halene S, Tebaldi T. Dissecting the stress granule RNA world: dynamics, strategies and data. RNA 2025, 31: rna.080409.125. PMID: 40086831, PMCID: PMC12084887, DOI: 10.1261/rna.080409.125.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStress granulesRNA worldRegulation of gene expressionRNA-binding proteinsCytoplasmic ribonucleoprotein granulesRibonucleoprotein granulesTranscriptome dataRNA componentSG dynamicsCell signalingSG compositionSG componentsGene expressionCellular adaptationHuman diseasesStress conditionsExperimental strategiesRNAProteinComprehensive understandingMRNAGranulesRegulation
Academic Achievements & Community Involvement
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Activities
activity Frontiers in Genetics - Computational Biology
2021 - PresentJournal ServiceAssociate Editoractivity PRIN 2020 MIUR
2021 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Yale Center for Biomedical Data Science
2018 - PresentProfessional OrganizationsMemberactivity Yale Cancer Center
2020 - PresentProfessional OrganizationsMemberactivity Italian Society of Yale Students and Affiliates
2017 - PresentProfessional OrganizationsBoard Member
Honors
honor Italian National Scientific Qualification as Associate Professor in Applied Biology
05/15/2021International AwardMinistry of Education, University and Research (Italy)DetailsItalyhonor Italian National Scientific Qualification as Associate Professor in Molecular Biology
01/14/2020International AwardMinistry of Education, University and Research (Italy)DetailsItalyhonor Yale YCCEH Pilot and Feasibility Program Award
11/13/2018Yale School of Medicine AwardYale YCCEHDetailsUnited Stateshonor RNA Society Travel Award: RNA2016, Kyoto
06/09/2016National AwardRNA SocietyDetailsUnited Stateshonor EMBO Travel Grant Award: Protein synthesis and translational control
07/21/2015International AwardEuropean Molecular Biology OrganizationDetailsGermany
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