Natalia Kunst, PhD
Postgraduate FellowAbout
Research
Publications
2025
Examining Consistency Across NICE Single Technology Appraisals: A Review of Appraisals for Paroxysmal Nocturnal Haemoglobinuria
Donoghue J, Youngs M, Reeve A, Vydyula K, Kunst N, Trikha R, Gallacher D. Examining Consistency Across NICE Single Technology Appraisals: A Review of Appraisals for Paroxysmal Nocturnal Haemoglobinuria. PharmacoEconomics 2025, 1-10. PMID: 39934600, DOI: 10.1007/s40273-025-01472-5.Peer-Reviewed Original ResearchSingle Technology AppraisalNational Institute for Health and Care ExcellenceTechnology appraisalCost-effectiveness evidenceParoxysmal nocturnal haemoglobinuriaEconomic modelExamination consistAppraisalCare ExcellenceHealth technologiesFollow-up lengthImplementation of health technologyIndirect comparisonsDose escalationCost-effective healthcareEvidenceClinical evidencePositive recommendations
2024
SA49 Drug Approval Under Uncertainty Across the COVID-19 Timeline: Cumulative Evidence Versus Value of Information Analyses
Dijk S, Krijkamp E, Kunst N, Gross C, Labrecque J, Pandit A, Lu C, Visser L, Wong J, Hunink M. SA49 Drug Approval Under Uncertainty Across the COVID-19 Timeline: Cumulative Evidence Versus Value of Information Analyses. Value In Health 2024, 27: s623. DOI: 10.1016/j.jval.2024.10.3130.Peer-Reviewed Original ResearchHTA224 A Roadmap to the Use of Value of Information Analysis in Health Technology Assessment: An International Study of Barriers, Facilitators, and Potential Applications
Grimm S, Glynn D, Coyle D, Jalal H, Koffijberg E, Tuffaha H, Vervaart M, Welton N, Wilson E, Rothery C, Kunst N. HTA224 A Roadmap to the Use of Value of Information Analysis in Health Technology Assessment: An International Study of Barriers, Facilitators, and Potential Applications. Value In Health 2024, 27: s398. DOI: 10.1016/j.jval.2024.10.2049.Peer-Reviewed Original ResearchMSR67 Comparison of Multi-Cancer Early Detection Modelling Approaches: Appraisal of the Methods
Mandrik L, Whyte S, Kunst N, Palmer S, Soares M. MSR67 Comparison of Multi-Cancer Early Detection Modelling Approaches: Appraisal of the Methods. Value In Health 2024, 27: s450-s451. DOI: 10.1016/j.jval.2024.10.2301.Peer-Reviewed Original ResearchEvaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study
Morgante N, Bjørnelv G, Aasdahl L, Nguyen C, Fimland M, Kunst N, Burger E. Evaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study. Value In Health 2024, 28: 415-423. PMID: 39579934, DOI: 10.1016/j.jval.2024.10.3850.Peer-Reviewed Original ResearchQuality-adjusted life yearsReturn to workO-ACTReturn-to-work interventionsHealth-related quality of lifeDecision-analytic modelRates of sickness absenceHealth-related qualityCost-effectiveQuality of lifeRTW interventionsProductivity lossSickness absenceSick leaveCost-effectiveness thresholdRegistry dataHealthcare costsNorwegian guidelinesHealthcare perspectiveLife yearsSocietal perspectiveEconomic evaluationInterventionTrial outcomesPsychological disordersLong-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer
Kunst N, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Rabil M, Ghaffar U, Karnes R, Ma X, Gross C, Wang S, Leapman M. Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer. JAMA Network Open 2024, 7: e2440591. PMID: 39441595, PMCID: PMC11581571, DOI: 10.1001/jamanetworkopen.2024.40591.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate-specific antigen levelPSMA-PETRecurrent prostate cancerBiochemical recurrenceProstate cancerLong-term outcomesProstate-specific membrane antigen positron emission tomographyEvaluation of biochemical recurrenceDetection of biochemical recurrenceLife yearsConventional imagingDefinitive local therapyPSMA PET imagingProstate cancer deathDetection of metastasesRetrospective cohort studyBase case analysisIncremental life-yearsPositron emission tomographyDecision-analytic modelLocal therapyConventional imaging strategiesDelayed treatmentDisease courseNet Monetary Benefit Lines Augmented with Value-of-Information Measures to Present the Results of Economic Evaluations under Uncertainty
Yaesoubi R, Kunst N. Net Monetary Benefit Lines Augmented with Value-of-Information Measures to Present the Results of Economic Evaluations under Uncertainty. Medical Decision Making 2024, 44: 770-786. PMID: 39056310, DOI: 10.1177/0272989x241262343.Peer-Reviewed Original ResearchResults of cost-effectiveness analysesNet monetary benefitCost-effectiveness planeCost-effectiveness analysisMonetary benefitsDecision uncertaintyDecision problemEffect estimatesHypothetical decision problemResults of economic evaluationsValue-of-informationDecision makersCost-effectiveness ratioEconomic evaluation studiesCorrelated costsHigh varianceLevel of uncertaintyParameter uncertaintiesEconomic evaluationMagnitude of parametersMakersDecisionUncertaintyCostMonetaryMaking Drug Approval Decisions in the Face of Uncertainty: Cumulative Evidence versus Value of Information
Dijk S, Krijkamp E, Kunst N, Labrecque J, Gross C, Pandit A, Lu C, Visser L, Wong J, Hunink M. Making Drug Approval Decisions in the Face of Uncertainty: Cumulative Evidence versus Value of Information. Medical Decision Making 2024, 44: 512-528. PMID: 38828516, PMCID: PMC11283736, DOI: 10.1177/0272989x241255047.Peer-Reviewed Original ResearchValue-of-informationVOI approachPolicy decisionsValue-of-information analysisSuboptimal resource useEvidence accumulationVOI resultsAdministrative policy decisionsDecision making resultsDecision-making strategiesApproval decisionsPolicy approachesMeta-analysisResearch settingsResource useHealth technology assessmentCrisis responseCase studyPolicyCumulative evidenceResource allocationComplexity of decisionsResearch prioritizationDecisionHealth outcomesPD45-10 PROSTATE-SPECIFIC MEMBRANE ANTIGEN IMAGING FINDINGS AND SUBSEQUENT CLINICAL MANAGEMENT AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: A RETROSPECTIVE COHORT STUDY
Leapman M, Rabil M, Ghaffar U, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Fallah J, Suzman D, Lerro C, Xu J, Kluetz P, Kunst N, Wang S, Ma X, Gross C, Karnes R. PD45-10 PROSTATE-SPECIFIC MEMBRANE ANTIGEN IMAGING FINDINGS AND SUBSEQUENT CLINICAL MANAGEMENT AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: A RETROSPECTIVE COHORT STUDY. Journal Of Urology 2024, 211: e971. DOI: 10.1097/01.ju.0001008792.09108.b4.10.Peer-Reviewed Original ResearchPD08-10 EFFECTIVENESS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN POSITRON EMISSION TOMOGRAPHY AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: RESULTS OF DECISION ANALYTIC MODELING
Kunst N, Long J, Westvold S, Sprenkle P, Rabil M, Ghaffar U, Kim I, Saperstein L, Wang S, Ma X, Gross C, Leapman M. PD08-10 EFFECTIVENESS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN POSITRON EMISSION TOMOGRAPHY AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: RESULTS OF DECISION ANALYTIC MODELING. Journal Of Urology 2024, 211: e177. DOI: 10.1097/01.ju.0001008576.33217.96.10.Peer-Reviewed Original Research