Mihaela Aslan, PhD
Research Scientist (General Medicine)DownloadHi-Res Photo
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Director, Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), Veterans Health Administration
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Research Scientist (General Medicine)
Positions outside Yale
Director, Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), Veterans Health Administration
Biography
Mihaela Aslan, Ph.D., is a graduate from the Department of Statistics at Yale University. As a mathematical statistician, she conducts methodological research on a range of topics, such as growth mixture models, competing risks methods in survival analysis, and observational methods to emulate randomized clinical trials. Multi-site observational study design represents another major methodological focus of Dr. Aslan's research. Some of her representative studies have focused on clinical topics such as prostate cancer, PTSD, suicidal ideation and behavior in patients with severe mental illness, Gulf War syndrome, and prediabetes. In her 23-year tenure with the Yale University School of Medicine and the VA Cooperative Studies Program (CSP), and in her current role as the Director of Clinical Epidemiology Research Center (CERC), her goals are centered around advancing scientific knowledge, and helping train the next generation of analysts on applied clinical epidemiology methods, for improving translation and implementation of research results into clinical practice, and to benefit the health and healthcare of Veterans, and by extension, of all human beings.
Last Updated on June 18, 2025.
Appointments
General Internal Medicine
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale University (2002)
- MS
- Yale University, Statistics
- MS
- University of Bucharest, Probability and Statistics
- BS
- University of Bucharest, Mathematics (1994)
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Mihaela Aslan's published research.
Publications Timeline
A big-picture view of Mihaela Aslan's research output by year.
Nallakkandi Rajeevan, PhD
John Concato, MD, FACP, MS, MPH
Hongyu Zhao, PhD
Lei Yan, PhD
Renato Polimanti, PhD, MSc
Joel Gelernter, MD
68Publications
1,928Citations
Publications
2025
Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Sriskantharajah V, Hynes D, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans. JAMA Internal Medicine 2025, 186 PMID: 41284307, PMCID: PMC12645397, DOI: 10.1001/jamainternmed.2025.6355.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRespiratory syncytial virus vaccineRespiratory syncytial virusIntensive care unit admissionRSV vaccineVaccine effectivenessUnit admissionRespiratory syncytial virus illnessSevere respiratory syncytial virusVaccine doseRespiratory syncytial virus infectionMonths of follow-upLong-term effectsHealth care useRespiratory illness seasonVeterans Health AdministrationMatched index dateUrgent care visitsTarget trial emulationMedian ageCare useCare visitsSingle doseSyncytial virusIndex dateVaccine recipientsImpact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies
Bajema K, Yan L, Berry K, Bui D, Lin H, Huang Y, Li Y, Rajeevan N, Maciejewski M, Smith V, Bohnert A, Hynes D, Aslan M, Ioannou G. Impact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies. American Journal Of Epidemiology 2025, kwaf221. PMID: 41078178, DOI: 10.1093/aje/kwaf221.Peer-Reviewed Original ResearchDefining and assessing international classification of disease suicidality phenotypes for genetic studies
Monson E, Colbert S, Barr P, Bejan C, Andreassen O, Ayinde O, Ceja Z, Coon H, DiBlasi E, Izotova A, Kaufman E, Koromina M, Myung W, Nurnberger J, Serretti A, Smoller J, Stein M, Zai C, Aslan M, Bigdeli T, Harvey P, Kimbrel N, Patel P, Ruderfer D, Docherty A, Mullins N, Mann J. Defining and assessing international classification of disease suicidality phenotypes for genetic studies. Psychiatry Research 2025, 353: 116760. PMID: 41061596, DOI: 10.1016/j.psychres.2025.116760.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInternational Classification of DiseasesPsychiatric Genomics ConsortiumInternational Classification of Diseases codesInternational ClassificationSuicidal ideationSample size requirementsClassification of diseasesPositive predictive valueClinician trainingAscertainment strategiesComparability of data setsPatient reportsICD codesGenetic studiesPhenotype definitionExpert consensusGenomics ConsortiumMultiple independent cohortsCohort characteristicsSuicidal phenotypeGenetic researchCode listsSex stratificationC-SSRSPatient responseBudget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System
Bui D, Hynes D, Wong E, Vergun R, Yan L, Li Y, Rajeevan N, Berry K, Lin H, Huang Y, Govier D, Aslan M, Ioannou G, Bajema K. Budget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System. Open Forum Infectious Diseases 2025, 12: ofaf596. PMID: 41089767, PMCID: PMC12517272, DOI: 10.1093/ofid/ofaf596.Peer-Reviewed Original ResearchAltmetricConceptsVeterans Health AdministrationHealthcare systemEmergency departmentBudget impactRisk quartileIntegrated healthcare systemHealthcare utilization costsHealthcare cost savingsHighest risk quartileTarget trial emulationHealth AdministrationHealthcare costsTrial emulationHealthcareCOVID-19VeteransHospitalTargeted treatmentQuartileClinical subgroupsUtilization costsTreatment benefitTargeted treatment of patientsCost savingsTreatment of patientsUnderstanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses
Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. Biological Psychiatry Global Open Science 2025, 5: 100588. PMID: 41036474, PMCID: PMC12483661, DOI: 10.1016/j.bpsgos.2025.100588.Peer-Reviewed Original ResearchCitationsConceptsChronic low back painSpinal degenerative diseaseLow back painPolygenic risk scoresMendelian randomizationBack painOne-sample Mendelian randomizationOne-sample MRRisk scoreUs Research ProgramPsychiatric disordersMultinominal regression modelGenetically informed analysesHealth outcomesMental illnessAlcohol use disorderPosttraumatic stress disorderDegenerative diseasesSociocultural factorsControl participantsRegression modelsUse disorderAssociated with differencesComorbidity patternsStress disorderCombining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation.
Mutalik P, Cheung K, Green J, Buelt-Gebhardt M, Anderson K, Jeanpaul V, McDonald L, Wininger M, Li Y, Rajeevan N, Jessel P, Moore H, Adabag S, Raitt M, Aslan M. Combining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation. AMIA Annual Symposium Proceedings 2025, 2024: 847-856. PMID: 40417550, PMCID: PMC12099393.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCorporate Data WarehouseNon-expertsClinical AI applicationsData warehouseAI applicationsVirtual emulationEHR dataClinical decision criteriaExtract informationCurated datasetComputational algorithmDecision criteriaTraining toolEmulationClinical notesStructural dataCase studyAlgorithmEHRDatasetWarehouseComputerInclusion/exclusion decisionsUnraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program
Pathak G, Koller D, Cabrera-Mendoza B, Djotsa A, Wendt F, De Lillo A, Friligkou E, He J, Kouakou M, Duong L, Vahey J, Steele L, Quaden R, Harrington K, Ahmed S, Gaziano J, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R, Program O. Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Human Molecular Genetics 2025, ddaf075. PMID: 40366759, DOI: 10.1093/hmg/ddaf075.Peer-Reviewed Original ResearchAltmetricConceptsPolygenic scoresGulf War IllnessGenome-wide dataDepression polygenic scoresPhenome-wide analysisDiverse ancestral backgroundsT2D polygenic scoreAssociated with higher oddsGulf War eraPolygenic architectureAncestral backgroundVeteran ProgramChronic conditionsHigher oddsType 2 diabetesGW veteransVeteransDisease pathogenesisDiverse participantsGulf WarOddsPhysical strengthIllnessComprehensive assessmentAnxietyCombining Cognitive‐Behaviour Therapy With Mindfulness Training in a Digital Intervention for Binge Eating Disorder: A Single‐Session Pilot Trial
Sala M, Roos C, Kober H, Bricker J, Stern C, Plutchik J, John M, Haeny A, Feldman J, Aslan M, Hay J, Forman E. Combining Cognitive‐Behaviour Therapy With Mindfulness Training in a Digital Intervention for Binge Eating Disorder: A Single‐Session Pilot Trial. European Eating Disorders Review 2025, 33: 1051-1060. PMID: 40350587, PMCID: PMC12318168, DOI: 10.1002/erv.3204.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBinge Eating ScaleBinge eating episodesCognitive behavioral therapyEating Disorder SymptomsBinge-eating disorderEDE-QDisorder symptomsMindfulness trainingEating episodesGlobal eating disorder symptomsBinge Eating Scale scoresEating Disorder Examination QuestionnaireReducing binge eatingCognitive-behavioral therapyBinge Eating DisorderSingle-session interventionEnglish-speaking adultsCognitive-behavioralBinge eatingBehavioral therapyEating ScaleExamination QuestionnaireEating DisordersEpisodic questionsDigital interventions505. Understanding the Pleiotropy Contributing to the Comorbidities Among Psychopathology, Chronic Back Pain, and Spinal Degenerative Disease
Qiu D, Friligkou E, He J, Mendoza B, Aslan M, Gupta M, Polimanti R. 505. Understanding the Pleiotropy Contributing to the Comorbidities Among Psychopathology, Chronic Back Pain, and Spinal Degenerative Disease. Biological Psychiatry 2025, 97: s305-s306. DOI: 10.1016/j.biopsych.2025.02.744.Peer-Reviewed Original ResearchSeverity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus. JAMA Internal Medicine 2025, 185: 324-334. PMID: 39869355, PMCID: PMC11773409, DOI: 10.1001/jamainternmed.2024.7452.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRespiratory syncytial virusLong-term mortalitySARS-CoV-2Syncytial virusCohort studyAssociated with higher long-term mortalityRisk differenceIntensive care unit admissionSeasonal influenza vaccineRetrospective cohort studyDisease severity of COVID-19Long-term deathAssociated with more severe disease outcomesRisk of deathCompare disease severitySevere disease outcomesRisk of hospitalizationSeverity of COVID-19Same-day testingInfluenza vaccineInverse probability weightingUnit admissionCumulative incidenceMortality of COVID-19Primary outcome
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