Mark Perazella, MD
Professor Emeritus of MedicineDownloadHi-Res Photo
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Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
About
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Titles
Professor Emeritus of Medicine
Director, Acute Dialysis Unit; Medical Director, Yale Physician Associate Program; Medical Director, Yale PA Online Program
Appointments
Nephrology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- MD
- New York Medical College (1988)
- Resident
- St. Mary's Hospital
- Fellow
- Yale University School of Medicine
Research
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Overview
Medical Research Interests
Dialysis; Drug-Related Side Effects and Adverse Reactions; Hemodialysis Units, Hospital; HIV; Hypotension; Kidney Diseases; Kidney Failure, Chronic; Nephrogenic Fibrosing Dermopathy; Nephrology
ORCID
0000-0002-6994-2659
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mark Perazella's published research.
Publications Timeline
A big-picture view of Mark Perazella's research output by year.
Research Interests
Research topics Mark Perazella is interested in exploring.
Dennis G Moledina, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Randy Luciano, MD, PhD
Megan Leila Baker, MD
Ali Abu-Alfa, MD, FASN, FAHA
Gilbert Moeckel, MD, PhD, FASN
173Publications
6,425Citations
Kidney Failure, Chronic
Kidney Diseases
Drug-Related Side Effects and Adverse Reactions
Hypotension
Nephrology
Publications
2025
The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup
Renaghan A, Ostermann M, Ronco C, Ballen K, Cosmai L, Fenoglio R, Floris M, Forni L, Gladstone D, Glezerman I, Goldstein S, Gupta S, Herrmann S, Jaimes E, Jhaveri K, Karam S, Kitchlu A, Landau H, Latcha S, Leaf D, Lentini P, Małyszko J, Markowitz G, Murakami N, Pani A, Perazella M, Rashidi A, Roccatello D, Sharon E, Sprangers B, Tesař V, Torres V, Wanchoo R, Whitman A, Workeneh B, Zepeda-Orozco D, Rosner M. The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup. Nature Reviews Nephrology 2025, 1-18. PMID: 41361704, DOI: 10.1038/s41581-025-01031-3.Peer-Reviewed Original ResearchAltmetricConceptsKidney diseaseNephrotoxic effectsDrug doseChimeric antigen receptor T-cell therapyEffects of anti-cancer therapyEarly detection of nephrotoxicityEffective conventional chemotherapyImmune-based therapiesT-cell therapyHaematopoietic cell transplantationOptimal drug doseDetection of nephrotoxicityEarly detectionAnti-cancer therapyKidney replacement therapyChronic kidney diseaseLife-saving therapyAcute kidney diseaseKidney function estimationInternational panel of expertsTherapy toxicityConventional chemotherapyCell transplantationTargeted therapyReplacement therapyOnco-nephrology education marches on: Highlights from the Turin Onco-Nephrology Congress
Rashidi A, Perazella M. Onco-nephrology education marches on: Highlights from the Turin Onco-Nephrology Congress. Journal Of Onco-Nephrology 2025 DOI: 10.1177/23993693251398908.Peer-Reviewed Original ResearchUrine Microscopy
Cavanaugh C, Perazella M. Urine Microscopy. Kidney360 2025, 6: 1837-1839. PMID: 41264406, PMCID: PMC12626671, DOI: 10.34067/kid.0000000985.Peer-Reviewed Original ResearchNephrotoxicity of conventional chemotherapeutics: part 1—platinum compounds and antimetabolite agents
Kelly A, Sharma S, Mamlouk O, Hassanein M, Chowdhury R, Gupta S, Troung H, Bonilla M, Kalra K, Wanchoo R, Pariswala T, Turcotte A, Zaveri I, Dernell C, Ibrahim M, Patel M, Eskander S, Gudsoorkar P, Jhaveri K, Perazella M, Hanna P. Nephrotoxicity of conventional chemotherapeutics: part 1—platinum compounds and antimetabolite agents. Nephrology Dialysis Transplantation 2025, gfaf251. PMID: 41247096, DOI: 10.1093/ndt/gfaf251.Peer-Reviewed Original ResearchAltmetricNephrotoxicity of conventional chemotherapeutics: part II—non-platinum agents and miscellaneous nephrotoxic drugs
Kelly A, Sharma S, Mamlouk O, Hassanein M, Chowdhury R, Gupta S, Truong H, Bonilla M, Kalra K, Wanchoo R, Pariswala T, Turcotte A, Zaveri I, Dernell C, Ibrahim M, Patel M, Eskander S, Gudsoorkar P, Jhaveri K, Perazella M, Hanna P. Nephrotoxicity of conventional chemotherapeutics: part II—non-platinum agents and miscellaneous nephrotoxic drugs. Nephrology Dialysis Transplantation 2025, gfaf220. PMID: 41105138, DOI: 10.1093/ndt/gfaf220.Peer-Reviewed Original ResearchAltmetricConceptsKidney-protective strategiesAdverse kidney outcomesOncological benefitNephrotoxic drugsPredictive biomarkersKidney outcomesToxicity profileCytotoxic drugsChemotherapeutic agentsKidney functionRenal implicationsAnticancer therapyNephrotoxic effectsSide effectsAlkylating agentsNephrotoxicityPatientsCancerKidneyDrugPreventive measuresAgentsAssociation of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis
Mukherjee J, Sadarangani S, Shelton K, Shaw M, Liang C, Koval E, Kent C, Perazella M, Luciano R, Turner J, Moeckel G, Kuperman M, Rosenberg A, Kumar D, Wilson F, Parikh C, Moledina D. Association of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025555bfcpt. DOI: 10.1681/asn.2025555bfcpt.Peer-Reviewed Original ResearchUrinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis
Sadarangani S, Obeid W, Moeckel G, Kuperman M, Kumar D, Rosenberg A, Perazella M, Turner J, Luciano R, Parikh C, Moledina D. Urinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.20258762wsmf. DOI: 10.1681/asn.20258762wsmf.Peer-Reviewed Original ResearchAssociation of Kidney Biopsy Needle Gauge with Postprocedure Complications and Biopsy Adequacy
Staunton M, Garg K, Sadarangani S, Makhijani A, Shelton K, Koval E, Liang C, Shaw M, Kent C, Wilson F, Parikh C, Perazella M, Turner J, Luciano R, Moledina D. Association of Kidney Biopsy Needle Gauge with Postprocedure Complications and Biopsy Adequacy. Kidney360 2025, 6: 1682-1688. PMID: 40402808, DOI: 10.34067/kid.0000000835.Peer-Reviewed Original ResearchAltmetricConceptsOdds of complicationsKidney biopsyOutcomes of blood transfusionBiopsy-related complicationsPropensity score weighting analysisBleeding risk factorsG biopsy needlePost-procedural complicationsScore-weighted analysisHemoglobin dropAngiographic interventionBlood transfusionPost-procedureComplication riskUnivariate analysisAssess safetyComposite outcomeDiagnostic adequacyBiopsy adequacyBiopsyG needleMultivariate analysisComplicationsRisk factorsNeedle gaugeUpdate on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches
Sahutoglu T, Perazella M. Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches. Kidney International Reports 2025, 10: 1643-1656. PMID: 40630288, PMCID: PMC12231035, DOI: 10.1016/j.ekir.2025.03.050.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute tubulointerstitial nephritisAcute kidney injuryC-reactive proteinAcute kidney diseaseTubulointerstitial nephritisType IV hypersensitivity mechanismKidney diseaseAcute kidney injury etiologyTh2-mediated immune responsesSerum C-reactive proteinTriggered by medicationsTumor necrosis factor (TNF)-aInterleukin (IL)-9Urinary retinol-binding proteinT helper (Th)1T cell polarizationIrreversible kidney damageInflammatory endotypesImprove patient outcomesPrompt diagnosisKidney biopsyT cellsClinical featuresDiagnostic challengeImmune heterogeneityIs Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful?
Perazella M. Is Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful? Kidney360 2025, 6: 9-11. PMID: 40146910, PMCID: PMC11793183, DOI: 10.34067/kid.0000000636.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity American Society of Nephrology
07/01/2015 - PresentMeeting Planning and ParticipationDirectorDetailsASN Education Co-Director, Board Review Course and Update (BRCU)activity National Kidney Foundation
05/01/2019 - PresentMeeting Planning and ParticipationChairDetailsChair of the NKF Spring Clinical Meeting 2020 (Co-Chair for the meeting in 2019)activity American Society of Nephrology
07/01/2019 - PresentJournal ServiceEditorDetailsDeputy Editor for ASN journal Kidney360activity Italian Society of Nephrology
07/01/2017 - PresentJournal ServiceEditorDetailsCo-Editor-in-Chief for the Journal of Onco-Nephrologyactivity American Society of Nephrology
11/01/2013 - 11/01/2017Meeting Planning and ParticipationChairDetailsChair of the ASN Onco-Nephology Forum
Honors
honor Robert G. Narins Lifetime Achievement Award in Education
07/07/2022National AwardAmerican Society of NephrologyDetailsUnited Stateshonor Donald W. Seldin Distinguished Award
10/02/2020National AwardNational Kidney FoundationDetailsUnited Stateshonor Department of Medicine Faculty Achievement Award in Education
07/01/2005Yale School of Medicine AwardYale University, Department of MedicineDetailsUnited States
News
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News
- December 01, 2023
Dr. Mark Perazella, Internationally Renowned Nephrologist, Retires at Year End
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
- May 25, 2023
YSM PA Online Graduates Celebrated for "Fierce Advocacy"
- May 11, 2023
Discoveries & Impact (May 2023)
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