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Jason Jonathon Sico, MD, MHS, FAHA, FAAN (Neurology), FANA, FACP, FAHS

Professor of Neurology
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Additional Titles

Associate Professor Internal Medicine (Section of General Medicine), Internal Medicine

Director, Stroke Care VA Connecticut Healthcare System

Director of Research and Clinical Care, Headache Center of Excellence, Neurology, VA Connecticut Healthcare System

About

To care for him who shall have borne the battle and for his widow and his orphan.

Abraham Lincoln, Second Inaugural Address, March 4, 1865

Titles

Professor of Neurology

Associate Professor Internal Medicine (Section of General Medicine), Internal Medicine; Director, Stroke Care VA Connecticut Healthcare System

Positions outside Yale

Director of Research and Clinical Care, Headache Center of Excellence, Neurology, VA Connecticut Healthcare System

Biography

I am a Professor of Neurology and Associate Professor of Internal Medicine at Yale School of Medicine and a board-certified neurologist and primary care internist within the VA Connecticut Healthcare System, providing both specialty and general care services for Veterans with neurological disease, specifically headache and ischemic stroke.

I am the National Director for the Headache Centers of Excellence (HCoE) Program within the Veterans Health Administration. The HCoE is a Congressionally-mandated national initiative to improve headache care quality and delivery through educational programs, innovative care delivery models, including telehealth, and standardized care algorithms that incorporate patient self-management and interdisciplinary headache care. I also serve as the Director of the HCoE RE3ACH (Research, Education, Evaluation, and Engagement Activities Center for Headache), which is tasked with understanding the epidemiology and role of military exposures in headache among Veterans and integrating with the educational and community engagement missions of the HCoE to create a true Learning Headache Health System within the Department of Veterans Affairs.

My research interests focus on disease-specific areas such as headache disorders (including migraine and post-traumatic headache), ischemic stroke, sleep apnea, and the effects of medical comorbidities (e.g., HIV, diabetes) on neurological outcomes, particularly within Veteran and military populations. Methodologically, I specialize in health systems research, implementation science, pragmatic and cluster randomized controlled trials, and the application of systems redesign and Lean Six Sigma principles to improve care delivery, care transitions, and patient-provider communication across and within learning health systems.

As a clinical trialist, I recently co-led a team that completed "Addressing Sleep Apnea Post-Stroke/TIA" (ASAP; NCT04322162) the first facility-level cluster randomized controlled trial intended to improve rates of guideline-recommended OSA testing and treatment through local quality improvement initiatives (QI) conducted within and across 6 VA Medical Centers. I am currently an MPI on an NCCIH-funded trial, "Chiropractic Care for Episodic Migraine" (NCT06229834), a two-site pilot randomized attention-controlled trial comparing chiropractic care to headache health education among those living with episodic migraine.

I am also keenly interested in the policy implications of research. I am actively involved in several key committees and subcommittees within Neurology and Internal Medicine, including the American Academy of Neurology (including Advocacy, Health Policy, and Members Research), American Headache Society, and the American College of Physicians (specifically the Council of Subspecialty Societies). I regularly present research findings related to neurological care among Veterans to Congressional members staff, leadership within the Veterans Health Administration, and healthcare advocacy organizations.

Last Updated on November 14, 2025.

Appointments

Education & Training

MHS
Yale University School of Medicine (2016)
VA Special Fellow in Neuroscience
VA Connecticut Healthcare System, West Haven Campus (2011)
Resident
Yale New Haven Hospital (2009)
Internship
Yale New Haven Hospital (2004)
MD
Temple University School of Medicine (2003)
BS
University of Scranton (1999)

Research

In service-driven research, every insight is a step toward honoring those we serve.

Jason J. Sico, MD, MHS

Overview

  • Health Services and Health Systems Research
  • Implementation Science
  • Improving Post-Stroke Vascular Risk Factor Control
  • Hypertension Control and Management
  • Screening for and Testing Obstructive Sleep Apnea among Stroke Survivors
  • Medical comorbidities and their influence on stroke outcome
  • Use of Systems Redesign/Health Systems Engineering in Stroke Care
  • Pragmatic Trials
  • Organizational and Provider-level Interventions
  • HIV and Ischemic Stroke in the era of combined antiretroviral therapy
  • HIV Neuropathy
  • Neurological Disease among Veterans and Active Military Personnel
  • Headache Care
  • Pain
  • Demonstrating the Value of Neurologists among Patients with Neurological Conditions
  • Care Collaboration between Specialists and Generalists
  • Burnout among Neurologists



Medical Research Interests

Acquired Immunodeficiency Syndrome; Burnout, Professional; Global Health; Headache; Health Services Research; HIV; Migraine Disorders; Mortality; Neurology; Organizational Innovation; Qualitative Research; Sleep Apnea, Obstructive; Stroke; Veterans

Public Health Interests

Qualitative Methods; Health Policy; Epidemiology Methods; Health Care Quality, Efficiency; Implementation Science; Health Systems Reform; Clinical Trials

Research at a Glance

Yale Co-Authors

Frequent collaborators of Jason Jonathon Sico's published research.

Publications

2025

2024

Academic Achievements & Community Involvement

Activities

  • activity

    American Academy of Neurology

Honors

  • honor

    Board of Directors Member

  • honor

    Clinical Epidemiology Fellow

  • honor

    Young Investigator Career Development Award

  • honor

    Young Investigator Award

  • honor

    International Health Scholar

Clinical Care

The act of caring for another is the ultimate expression of humanity.

Inspired by the writings of Oliver Sacks, MD

Overview

Jason Sico, MD, MHS, is a neurologist and internal medicine physician who sees patients at the VA Medical Center in West Haven, where he specializes in headache and stroke care.

Dr. Sico says he knew he wanted to be a physician since he was 4. “I feel blessed every day that I am in a service-oriented profession. I learn so much from being in health care and working one-on-one with patients,” he says. “When you learn about each patient and how you can best help them, they open up. They aren’t a symptom or a list of medications or a past medical history. They are a living, breathing, wonderful person, and it’s my goal to make sure they have a vibrant life and are as healthy as possible.”

Reaching that goal, Dr. Sico says, is finding ways to prevent illness and understanding the concerns that brought the patient to see him. One of the best parts of his job, he adds, is his dual training as a neurologist and internist. “I did this to be able to look at neurologic diseases that are common in primary care. There aren’t enough neurologists in the country, which is expected to get worse as the population continues to age and we see more diseases like Alzheimer’s and Parkinson’s,” he says.

Dr. Sico also helped establish a national telestroke program across the Veterans Health Administration.

“We service over 70 different hospitals. If a veteran is suspected of having a stroke, they'll start off with an evaluation,” he explains. “They'll give someone like me a call, and then we'll get on the iPad and talk to them through a telehealth application. Plus, we outfit all the medical centers with the equipment that they need to do things at their end. We figure out what steps they need to take very quickly because for acute stroke care, the sooner we can decide someone is having a stroke and offer them clot-busting medication or other therapies, the better.”

For stroke research, Dr. Sico is interested in secondary prevention. “Once someone has had a transient ischemic attack, or TIA, we want to know if we can identify what contributed to their stroke in the first place. What we need to do to meet their evolved needs and how could we prevent another stroke,” he says. “My research also includes entire healthcare system interventions to help improve care transitions as people go back into the community and in a way that improves communication and collaboration between the specialists who took care of them in the hospital and their primary care providers who give them longitudinal care for issues like high blood pressure, high cholesterol, and other issues.”

Other research pursuits include addressing post-stroke sleep apnea, which is common, and working with headache disorders, including using cognitive behavioral therapy (CBT) for headache and migraine disease.

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