2025
Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness
Parikh R, Nayak D, Lin H, Gangaraju V. Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness. Journal Of Biological Chemistry 2025, 108210. PMID: 39848495, DOI: 10.1016/j.jbc.2025.108210.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsDevelopmental robustnessTE silencingSilencing of transposable elementsP-element induced wimpy testisPreserving genome integrityHistone 3 lysineIntrinsic genetic variationPost-transcriptional silencingMammalian nucleolinTransposon RNAsTransposon silencingPiRNA functionPiwi-piRNATE activityGenomic sitesMaternal germlineArgonaute 3Genome integrityTranscriptional silencingGenetic variationEpigenetic regulationPIWIBinding protein
2024
Piwi regulates the usage of alternative transcription start sites in the Drosophila ovary
Chen J, Liu N, Qi H, Neuenkirchen N, Huang Y, Lin H. Piwi regulates the usage of alternative transcription start sites in the Drosophila ovary. Nucleic Acids Research 2024, gkae1160. PMID: 39657757, DOI: 10.1093/nar/gkae1160.Peer-Reviewed Original ResearchTranscription start siteTranscription start site usageFacilitates chromatin transcriptionDrosophila ovaryOvarian somatic cellsStart siteCap analysis of gene expression sequencingAlternative transcription start sitesSomatic cellsPol II initiationRNA polymerase IIAlternative transcription initiationRNA-binding proteinsCultured ovarian somatic cellsGene expression sequencingMRNA elongationPolymerase IIPol IITranscription initiationChromatin transcriptionTranscriptional regulationExpressed sequencesMutant ovariesPIWICap analysis
2008
The Role of piRNAs in Germline Stem Cell Division and Spermatogenesis.
Lin H. The Role of piRNAs in Germline Stem Cell Division and Spermatogenesis. Biology Of Reproduction 2008, 78: 281-281. DOI: 10.1093/biolreprod/78.s1.281a.Peer-Reviewed Original ResearchPIWI-interacting RNAsPIWI subfamily proteinsSubfamily proteinsProtein familyDiverse mechanisms of gene regulationGermline stem cell divisionMechanisms of gene regulationRegulation of mRNA stabilityGermline stem cellsNon-coding small RNAsStem cell self-renewalStem cell divisionPiwi subfamilyGenomic distributionCell self-renewalRepetitive sequencesIntron sequencesGene regulationSmall RNAsSelf-renewalGametogenic eventsCell divisionDiverse organismsPIWIMRNA stability