Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis
Gupta V, Janda G, Pump H, Lele N, Cruz I, Cohen I, Ruff W, Hafler D, Sung J, Longbrake E. Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis. Neurology Neuroimmunology & Neuroinflammation 2025, 12: e200355. PMID: 39819054, PMCID: PMC11741292, DOI: 10.1212/nxi.0000000000200355.Peer-Reviewed Original ResearchConceptsAmplicon sequence variantsIgA-coatedGut microbiomeBacterial fractionRRNA gene amplicon sequencingLong-read sequencingGut microbial symbiontsGene amplicon sequencingMultiple sclerosisStool samplesProportion of bacteriaB cellsHost-microbial interfaceAnti-CD20 monoclonal antibody treatmentDiagnosing MSMicrobial symbiontsIgA-secreting B cellsTaxonomic resolutionSequence variantsAmplicon sequencingB-cell depletionFecal microbiotaMonths of treatmentMonoclonal antibody treatmentDevelopment of autoimmunity