Marc Schneeberger Pane, PhD
Assistant Professor in Cellular and Molecular PhysiologyCards
Appointments
Contact Info
Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States
About
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Titles
Assistant Professor in Cellular and Molecular Physiology
Biography
Marc Schneeberger Pané received his B.S. in Pharmacy from Barcelona University, Catalonia in 2010. Next, he received his M.S. in Biomedicine from Barcelona University, Catalonia in 2011. He then studied how the powerhouse of the cell (mitochondria) is responsible for controlling whole body energy balance and metabolism in the canonical site for energy balance control (hypothalamus) with Marc Claret, PhD and earned his Ph.D. in Biomedicine at the Barcelona University, Catalonia in 2015. He then became a KAVLI postdoctoral fellow and a Pathway to Independence fellow in Prof. Jeffrey M.Friedman laboratory at The Rockefeller University. There he conducted whole mount activity maps in energy states to decipher the role of two novel subsets of neurons in the Dorsal Raphe Nucleus of the brainstem in energy balance control. He joined the Department of Cellular and Molecular Physiology at Yale University School of Medicine as an Assistant Professor in July 2022.
The Schneeberger Pané laboratory employs state-of-the-art technologies in neuroscience combining unbiased whole mount imaging of circuits, activity and vasculature; molecular profiling single-cell gene expression technologies, neuoromodulation (optogenetics, and chemogenetics) to understand the fundamental principles in the brain governing homeostasis. The overarching goal of the laboratory is to advance in the understanding of how neuronal, immune and vascular networks coordinately control homeostasis, with a focus on energy homeostasis.
Appointments
Cellular & Molecular Physiology
Assistant ProfessorPrimary
Other Departments & Organizations
- Cancer Signaling Networks
- Cellular & Molecular Physiology
- Interdepartmental Neuroscience Program
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neuroscience Track
- Wu Tsai Institute
- Yale Cancer Center
- Yale Center for Molecular and Systems Metabolism (YMSM)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- NIH Pathway to Independence K99 Fellow
- The Rockefeller University (2022)
- Instructor
- Yale University (2022)
- KAVLI Postdoctoral Fellow
- The Rockefeller University (2019)
- JPB Postdoctoral Fellow
- The Rockefeller University (2017)
- PhD
- Barcelona University, Medicine (2015)
- MS
- Barcelona University, Biomedicine (2011)
- BS
- Barcelona University, Pharmacy (2010)
Research
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Overview
Medical Research Interests
ORCID
0000-0001-7369-104X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
David Meseguer Garcia
Tamas Horvath, DVM, PhD
María José Ortuño Romero, PhD
Jean-Leon Thomas, PhD
Jose G Grajales-Reyes, MD, PhD
Matthias Tschoep, MD
Nervous System Diseases
Publications
2026
3064-LB: Mitochondrial Protonophore TLC-1180 Mitigates Cognitive Decline in Diet-Induced Obese Mice
GASPAR R, MORGAN H, PARIKH S, FURTADO J, ISAZA J, ZHENG J, SUCUPIRA F, SHARMA M, MYERS R, SUBRAMANIAN G, VIJAYAKUMAR A, PANE M, SHULMAN G. 3064-LB: Mitochondrial Protonophore TLC-1180 Mitigates Cognitive Decline in Diet-Induced Obese Mice. Diabetes 2026, 75 DOI: 10.2337/db26-3064-lb.Peer-Reviewed Original ResearchConceptsNovel object recognition testOpen field testNeuronal activityCognitive declineHigh-fat dietImpaired recognition memoryRecognition memory performanceC-Fos-positive cellsObject recognition testC-Fos immunohistochemistryC-fosC-fos expressionRecognition memoryMale C57BL/6J miceMemory performanceBehavioral deficitsBehavioral performanceRecognition testRegular chowExploratory activitySucrose intakeCognitive performanceCognitive behaviorExploratory behaviorPharmacological correctionGlycogen drives the sensory activation of POMC neurons
Gómez-Valadés A, Meseguer D, Varela L, Lienhard G, Fernández U, Vidal-Itriago A, Toledo M, Eyre E, Laudo B, Díaz-Castro F, Pozo M, Boutagouga Boudjadja M, Fos-Domènech J, García-Ramón P, Ferreira M, Altirriba J, Beiroa D, Chen B, Rodríguez-Díaz A, Milà-Guasch M, Chivite I, Obri A, Ramírez S, Haddad-Tóvolli R, Tahiri I, Gentry M, D’Agostino G, Nogueiras R, Renier N, Horvath T, Guinovart J, Duran J, Schneeberger M, Claret M. Glycogen drives the sensory activation of POMC neurons. Nature Metabolism 2026, 8: 1305-1329. PMID: 42204369, DOI: 10.1038/s42255-026-01535-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPOMC neuronsActivation of POMC neuronsPerception of foodSensory activityHypothalamic POMC neuronsGenetic depletionBiological functionsHigh-calorie dietSensory perception of foodPhysiological relevanceOvert diabetesSensory perceptionDefective perceptionPrediabetic phenotypesConsummatory behaviorInsulin releaseGlucose homeostasisNeuronsRegulatory modeSensory stimuliPOMCSystemic energy balanceGlycogen metabolismFood perceptionDepletion of glycogenA causal link between autoantibodies and neurological symptoms in long COVID
de Sá K, Silva J, Bayarri-Olmos R, Baker C, Lu Z, Gipson W, Na D, Chen B, Wenxue L, Khosroabadi D, Brinda R, Constable R, Omene B, Colom Díaz P, Kwon D, Rodrigues G, Heidecke H, Schulze-Forster K, Gross A, Shneer T, Clarke A, Linnekin T, Brate A, Brown L, Buda H, Jatiani S, Moise L, Greene K, Bhagchandani S, Bhattacharjee B, Gehlhausen J, Wood J, Tabacof L, Scheibenbogen C, Liu Y, Guan L, Schneeberger Pane M, Putrino D, Horvath T, Iwasaki A. A causal link between autoantibodies and neurological symptoms in long COVID. Cell 2026, 189: 3214-3235.e37. PMID: 42208499, DOI: 10.1016/j.cell.2026.04.042.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCentral nervous systemNeurological symptomsPatient's symptomsPain-related neuronal activityPassive transferAcute SARS-CoV-2 infectionAntibody-dependent phagocytosisTissue-based immunofluorescenceSARS-CoV-2 infectionPurified immunoglobulin GHuman locus coeruleusThermal hyperalgesiaFunctional autoantibodiesFatigue-like behaviorMass spectrometry assayMouse sciatic nerveTransfer of IgGAdrenal glandNerve damageLocus coeruleusPathogenic roleAutoantibodiesPassive transfer of IgGSciatic nerveAutoantibody targetsObesity and unhealthy aging connected through the neurovasculature
Pane M, Na D, Furtado J, Garcia D, Grajales J, Uribe J, Diaz A. Obesity and unhealthy aging connected through the neurovasculature. Physiology 2026, 41: 2290266. DOI: 10.1152/physiol.2026.41.s1.2290266.Peer-Reviewed Original ResearchAltmetricConceptsBlood-brain barrierGlial activationNeurovascular unitMouse modelPersistent low-grade inflammationGLP-1 receptor agonistsChronic high-fat diet feedingDisruption of blood-brain barrierBlood-brain barrier leakinessLow-grade inflammationWhite-matter injuryBlood-brain barrier dysfunctionBlood-brain barrier permeabilityNeurovascular unit impairmentElevated BBB permeabilityHigh-fat diet feedingCerebral blood flowChronic metabolic stressSystemic insulin resistanceReceptor agonistsExtracellular matrix pathwaysGLP-1RAClaudin-5Microglial reactivityCapillary rarefactionObesity as a catalyst for neurodegeneration
Chen B, Rodríguez-Díaz A, Schneeberger M, Topol E. Obesity as a catalyst for neurodegeneration. Nature Metabolism 2026, 8: 546-558. PMID: 41760887, DOI: 10.1038/s42255-026-01477-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsIdentification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked J, Page K, Barrows D, Carroll T, Grajales-Reyes J, Na D, Rodriguez-Diaz A, Furtado J, Isaza J, Schiffer H, Chen Y, Sun H, Kaushal N, Monenschein H, Barker D, Ortuño M, Renier N, Cohen P, Carlton M, Heintz N, Brice N, Friedman J, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nature Communications 2026, 17: 1295. PMID: 41530127, PMCID: PMC12868712, DOI: 10.1038/s41467-025-68056-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDorsal raphe nucleusRaphe nucleusChronic inhibitionMale miceInhibition of GABAergic neuronsSustained weight lossVentrolateral periaqueductal grayIn situ hybridizationHigh-fat dietGABAergic neuronsCounterregulatory mechanismsBrown adipose tissue thermogenesisAdipose tissue thermogenesisGenetic predispositionPeriaqueductal greyDiet-inducedMolecular profilingHigh-throughput drug screeningMetabolic phenotypeWeight managementInverse agonistsWeight lossHuman brainMiceBody weightNovel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice
Hunt J, Lund C, Chen B, Diaz A, Dmytriyeva O, Marcotorchino J, Löbner K, Mörl K, Andersen N, Ogueboule Z, Frank E, Stöhr J, Meseguer D, Panajotova V, Roux J, Clemmensen C, Sylow L, Schneeberger M, Beck‐Sickinger A, Pedersen S, Fosgerau K. Novel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice. Journal Of Cachexia Sarcopenia And Muscle 2026, 17: e70318. PMID: 42223236, PMCID: PMC13240157, DOI: 10.1002/jcsm.70318.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCancer cachexiaFood intakeLong-actingLean massTumor growthHealthy miceCancer cachexia mouse modelBody weightSubcutaneous injectionApplication of ghrelinGhrelin analoguesFat mass lossInvoluntary weight lossGrowth hormone secretionClinical applicationCD-1 miceIncreased food intakeTotal food intakeHealthy CD-1 miceDelta body weightCirculating growth hormoneUnmet medical needC26 modelHealthy ratsRestore energy balance
2025
Neurovascular plasticity as a modulator of hypothalamic function
Chen B, Furtado J, Schneeberger M. Neurovascular plasticity as a modulator of hypothalamic function. Reviews In Endocrine And Metabolic Disorders 2025, 27: 493-503. PMID: 40542999, DOI: 10.1007/s11154-025-09982-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsRegulation of homeostasisCentral regulatorRegulators of homeostatic processesNon-neuronal cellsMetabolic cuesReproductive regulationDiverse functionsNeuronal regulationHypothalamic-pituitary-gonadal axisNutrient fluxesAction of cellsHomeostatic processesHomeostasisMultiple nucleiCellular crosstalkTherapeutic targetRegulationMetabolic disordersHypothalamic functionHormone levelsCellsVascular remodelingAutonomic functionNeurovascular plasticityVascular componentCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWeight lossWhite adipose tissueAdipose browningCaloric restrictionAdipose tissueDietary amino acidsCysteine depletionSulphur amino acids cysteineIncreased energy expenditureAdipose tissue thermogenesisIncreased fat utilizationMetabolic inflammationNoradrenaline signalingOrganismal metabolismAdipose thermogenesisObese miceBrowning of adipocytesIncreased heat productionBrownRemoval of cysteineCore body temperatureAmino acidsEnergy expenditureAmino acid cysteineFat utilizationGLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation
Na D, Schneeberger Pané M. GLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation. Nature Aging 2025, 5: 960-961. PMID: 40394226, DOI: 10.1038/s43587-025-00881-7.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity Swiss National Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Israel Science Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Spanish National Evaluation and Foresight Agency
2019 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity ANR:AAP French National Agency
2020 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Argentinian Ministry of Science and Technology
2020 - PresentPeer Review Groups and Grant Study SectionsReviewer
Honors
honor Heidi Diabetes Award
09/24/2025International AwardHelmholtz ZenteumDetailsGermanyhonor Alzheimer Disease Research Center Scholar
05/01/2024Yale School of Medicine AwardNeurology DepartmentDetailsUnited Stateshonor Diabetes Research Center Scholar
05/01/2024Yale School of Medicine AwardEndocrinology DepartmentDetailsUnited Stateshonor Matilda Ziegler Foundation Scholar
01/01/2024National AwardMatilda E. Ziegler FoundationDetailsUnited Stateshonor Yale SenNet Scholar
01/01/2024Yale School of Medicine AwardYale Aging CenterDetailsUnited States
Teaching & Mentoring
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Mentoring
Amanda Rodriguez Diaz
Graduate student2023 - Present
Willing and Available to Mentor
- Residents
- Clinical Fellows
- Postdoctoral Researchers
- Students
News & Links
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Media
News
- June 30, 2026
Women’s Health Research at Yale and SWHR’s Symposium Highlights the Power of Collaboration to Advance Women’s Health Research
- June 02, 2026
New Discovery Explains How the Brain Prepares the Body for Food
- May 28, 2026Source: Yale News
Yale Study Links Some Long COVID Patients to Autoimmune Responses
Get In Touch
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Contacts
Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States