Bonnie Elyssa Gould Rothberg, MD, PhD, MPH

Assistant Professor of Medicine (Medical Oncology), of Epidemiology (Chronic Diseases) and of Pathology

Research Interests

Immunohistochemistry; Melanoma

Research Organizations

Cancer Prevention and Control

Medical Oncology

Pathology

School of Public Health

Research Summary

The prognosis for certain localized cancers, such as Stage II melanoma and Stage IA/IB non-small cell lung cancer is uncertain. Following curative-intent resection of the primary tumor, the long-term (5- or 10-year) overall survival for these patients can hover around 50%. At the same time, the morbidities associated with available adjuvant therapies precludes their use in the majority of these patients. Current prognostic models derived from conventional clinicopathologic parameters are insufficient to identify, at the time of diagnosis, the subset of patients at highest risk of recurrence for selective adjuvant therapy administration. The goal of my research program is to develop novel prognostic models for both early-stage non-small cell lung cancer and melanoma. Variables reflecting characteristics of the index tumor (somatic mutations, differential transcript profiling, differential protein expression), the patient's germline genetics as well as lifestyle behaviors are all simultaneously considered.

Extensive Research Description

1. Molecular prognostic models for cutaneous melanoma metastases

2. Mechanisms of benign metastasis in kidney angiomyolipomas

3. Radiogenomics in lung cancer

4. Energy balance in Stage I non-small cell lung cancer prognosis

Selected Publications

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Contact Info

Bonnie Elyssa Gould Rothberg, MD, PhD, MPH
Patient Care Location
St. Raphael's Adult Primary Care Center330 Orchard Street, Ste 2nd Floor
New Haven, CT 06511
Lab Location
Nathan Smith Building
315 Cedar Street, Ste 287B

New Haven, CT 06510
Office Location
Winchester Building
25 York Street, Ste WWW216

New Haven, CT 06511
Mailing Address
NSB287Yale Cancer Center
P.O. Box 208028

New Haven, CT 06520-8028