Ying Chen, MD, PhD

Research Scientist in Epidemiology (Environmental Health)

Research Interests

Digestive System Diseases; Disorders of Environmental Origin; Nervous System Diseases; Nutritional and Metabolic Diseases

Public Health Interests

Alcoholism/Alcohol; Environmental Health

Research Organizations

School of Public Health: Vasiliou Lab

Liver Center

Extensive Research Description

Dr. Chen’s research focuses on understanding the mechanistic functions of redox homeostasis and glutathione (GSH) deficiency in human diseases associated with environmental and dietary stress. Reduced GSH is the most abundant thiol antioxidant that combats excessive oxidants generated during cellular metabolism or in response to environmental assaults. GSH deficiency has been associated with numerous pathological conditions in human. Dr. Chen’s research work involves the use of animal models of GSH deficiency to elucidate the molecular mechanisms (e.g., genetic components and environmental factors) of fatty liver disease, diabetes and neurological disorders.

  • Redox-mediated Mechanisms in Protection Against Alcoholic and Non-alcoholic Fatty Liver Disease
  • Mouse Models for Alcohol Metabolism and Tissue Injury
  • The Role of ALDH1B1 in Ethanol Metabolism and Colon Cancer

Selected Publications

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