Mikhail Kostylev
Associate Research ScientistCards
About
Research
Publications
2024
Cellular Prion Protein Conformational Shift after Liquid–Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations
Liu Y, Tuttle M, Kostylev M, Roseman G, Zilm K, Strittmatter S. Cellular Prion Protein Conformational Shift after Liquid–Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations. Journal Of The American Chemical Society 2024, 146: 27903-27914. PMID: 39326869, PMCID: PMC11469297, DOI: 10.1021/jacs.4c10590.Peer-Reviewed Original ResearchConceptsLiquid-liquid phase separationCellular prion proteinAssociated with neurodegenerative diseasesAmyloid-bMaturation processDisordered proteinsPrion proteinConformational shiftProtein conformationConformational changesNeurodegenerative diseasesInduction conditionsConformational statesProteinPrPMutationsPhase separationSaturating concentrationsMolecular motionSolid-like stateMaturationDisease-related cognitive deficitsNeurodegenerationInductionAlzheimer
2015
F5‐02‐02: Aß oligomer induced signal transduction at the post‐synaptic density
Kaufman A, Kostylev M, Haas L, Salazar S, Strittmatter S. F5‐02‐02: Aß oligomer induced signal transduction at the post‐synaptic density. Alzheimer's & Dementia 2015, 11: p305-p305. DOI: 10.1016/j.jalz.2015.07.428.Peer-Reviewed Original Research
2014
A Synaptotoxic Pathway from Aβ oligomer to Prion Protein to mGluR5 to F kinase in Alzheimer's Disease
Strittmatter S, Kostylev M, Kaufman A, Haas L, Heiss J, Gunther E, Nygaard H. A Synaptotoxic Pathway from Aβ oligomer to Prion Protein to mGluR5 to F kinase in Alzheimer's Disease. Neurobiology Of Aging 2014, 35: s21. DOI: 10.1016/j.neurobiolaging.2014.01.112.Peer-Reviewed Original Research
2013
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Um J, Kaufman A, Kostylev M, Heiss J, Stagi M, Takahashi H, Kerrisk M, Vortmeyer A, Wisniewski T, Koleske A, Gunther E, Nygaard H, Strittmatter S. Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein. Neuron 2013, 80: 531. DOI: 10.1016/j.neuron.2013.10.001.Peer-Reviewed Original Research
2007
Correlation of the shoulder girdle asymmetry with the limb skeleton asymmetry in Xenopus laevis
Kostylev M, Malashichev Y. Correlation of the shoulder girdle asymmetry with the limb skeleton asymmetry in Xenopus laevis. Doklady Biological Sciences 2007, 416: 374-376. PMID: 18047022, DOI: 10.1134/s0012496607050146.Peer-Reviewed Original Research