Anti-CD3 targeted immune suppression
Prior studies in our laboratory showed that the monoclonal antibody Teplizumab (anti-CD3) can restore immune tolerance by induction and activation of T regulatory cells that counteract autoreactive T cells. Clinical studies indicate that even a single course of treatment with anti-CD3 can help preserve insulin production in new-onset Type 1 diabetes, and larger trials are currently ongoing to test the drug’s efficacy in both prevention and treatment of new-onset diabetes. (Read more: http://medicine.yale.edu/news/article.aspx?id=1037)
Demethylation and beta cell death
Anti-CTLA4 therapy-induced autoimmune disease
Cytotoxic T Lymphocyte- associated antigen 4 (CTLA-4) acts as a negative regulator of immune responses and affects T cell tolerance in humans. Antibodies that block CTLA4 have been approved for treatment of patients with metastatic melanoma, however these therapies also induce autoimmunity that affects a variety of organ systems including the GI tract, liver, skin, and endocrine function. Our lab is using a humanized mouse model to study anti-CTLA4-induced autoimmunity and its effect on different cell subsets and organs.