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Emile Boulpaep, MD

Professor Emeritus of and Senior Research Scientist in Cellular And Molecular Physiology
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Additional Titles

Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology

Contact Info

Cellular & Molecular Physiology

PO Box 208026, 333 Cedar Street

New Haven, CT 06520-8026

United States

About

Titles

Professor Emeritus of and Senior Research Scientist in Cellular And Molecular Physiology

Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology

Appointments

Other Departments & Organizations

Education & Training

MD
University of Louvain (1962)

Research

Overview

Polarized kidney tubule cells have proteins in the plasma membrane facing the urine that differ from those facing the blood. We are studying the electrical characteristics of these proteins-ion channels and electrogenic transporters-in the two plasma membranes of renal tubule cells. Patch-clamp, optical and molecular biology techniques are being used.

  1. We study the physiological role and regulation of single small-conductance chloride channels, which are activated by cAMP through phosphorylation by protein kinase A. Our interest is in the intracellular signal transduction pathways involved in the regulation of these renal channels and their homology with the CFTR protein, known to be deficient in cystic fibrosis.
  2. We study the physiological role and regulation of a cGMP-sensitive non-selective cation channel in the apical membrane of a kidney cell line and its homology with a cGMP-gated non-selective channel of the vertebrate photoreceptor.
  3. Using confocal vital microscopy and ion-sensitive fluorescent dyes, we study a model of proximal tubule cell injury induced by angiotensin II, which is accompanied by elevation of intracellular calcium and plasma membrane blebbing.

Medical Subject Headings (MeSH)

Kidney; Physiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Emile Boulpaep's published research.

Publications

2019

2016

2010

2009

Academic Achievements & Community Involvement

  • honor

    Bohmfalk Award for Excellence in Basic Science Teaching

  • honor

    Dean's Medical Education Farr Prize

  • honor

    Nobility title of Chevalier/Ridder.

  • honor

    Foreign Honorary Member, Royal Academy of Medicine of Belgium

  • honor

    Doctor Honoris Causa

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Contacts

Mailing Address

Cellular & Molecular Physiology

PO Box 208026, 333 Cedar Street

New Haven, CT 06520-8026

United States