2015
Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI
Wang P, Schuetz C, Vallabhajosyula P, Medarova Z, Tena A, Wei L, Yamada K, Deng S, Markmann JF, Sachs DH, Moore A. Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI. Transplantation 2015, 99: 1574-1581. PMID: 25806407, PMCID: PMC4551574, DOI: 10.1097/tp.0000000000000682.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBiomarkersBlood GlucoseContrast MediaDextransDisease Models, AnimalGraft RejectionImmunosuppressive AgentsIslets of LangerhansIslets of Langerhans TransplantationMagnetic Resonance ImagingMagnetite NanoparticlesMaleOrgan SizePapio hamadryasPredictive Value of TestsStreptozocinTime FactorsTransplantation, HomologousConceptsGraft volumeIslet graftsBlood glucosePancreatic isletsNonhuman primatesAcute graft lossAllogeneic immune rejectionAllogeneic islet graftsWithdrawal of immunosuppressionPancreatic islet graftsVivo MRIGraft lossAllogeneic isletsGraft monitoringTreatment optionsIslet lossIslet transplantationRenal capsuleAllogeneic modelAutologous modelImmune rejectionMRISecondary damageImmunosuppressionIslets
2011
Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers
Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Vallabhajosyula P, Moran S, Sachs DH. Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers. American Journal Of Transplantation 2011, 11: 2603-2612. PMID: 21929644, PMCID: PMC3226882, DOI: 10.1111/j.1600-6143.2011.03733.x.Peer-Reviewed Original ResearchConceptsInsulin therapyFree isletsRenal capsuleEnd-stage diabetic nephropathyNonhuman primate modelPotential clinical applicabilityImmunosuppressive regimenAllogeneic barriersTotal pancreatectomyDiabetic nephropathyFBS levelsDiabetic hyperglycemiaPrimate modelPartial pancreatectomyDonor isletsMiniature swineNormal rangePotential cureGlucose regulationClinical applicabilityIsletsPancreatectomyTherapyIKsRecipients
2009
In Vivo Imaging of Autologous Islet Grafts in the Liver and Under the Kidney Capsule in Non-Human Primates
Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In Vivo Imaging of Autologous Islet Grafts in the Liver and Under the Kidney Capsule in Non-Human Primates. Transplantation 2009, 87: 1659-1666. PMID: 19502957, PMCID: PMC2746764, DOI: 10.1097/tp.0b013e3181a5cbc0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisContrast MediaDextransFerrosoferric OxideInsulinInsulin SecretionIronIslets of Langerhans TransplantationKidneyLiver TransplantationMagnetic Resonance ImagingMagnetite NanoparticlesOxidesPancreatectomyPapioSubrenal Capsule AssayTransplantation, AutologousTransplantation, HeterologousConceptsMagnetic resonance imagingSuperparamagnetic iron oxide contrast agentIslet graftsIron oxide contrast agentNon-human primatesRenal subcapsular islet graftsNon-human primate modelIslet graft survivalVivo magnetic resonance imagingIntrahepatic graftsGraft survivalPosttransplantation periodKidney capsuleIslet transplantationPrimate modelRenal capsulePartial pancreatectomyLiver parenchymaContrast agentsDay 1Drug AdministrationIslet labelingClinical situationsHuman isletsResonance imaging
2007
Vascularized composite islet-kidney transplantation in a miniature swine model
Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochemistry And Biophysics 2007, 48: 201-207. PMID: 17709890, DOI: 10.1007/s12013-007-0027-4.Peer-Reviewed Original ResearchConceptsThymic tissueIslet equivalentsEnd-stage diabetic nephropathyType I diabetic patientsAllogeneic thymic tissueRecipient body weightLong-term toleranceLong-term survivalMiniature swine modelKidney allograftsMHC barriersDiabetic nephropathyAllogeneic isletsAllogeneic transplantationDiabetic hyperglycemiaDiabetic patientsThymic componentsTreatment regimensPortal veinRenal capsuleOrgan transplantsAutologous isletsMiniature swineTransplantationBody weight