Elisabete Weiderpass
Professor AdjunctCards
About
Research
Publications
2025
Identifying metabolomic mediators of the physical activity and colorectal cancer relationship.
Papadimitriou N, Kazmi N, Tsilidis K, Richmond R, Lynch B, Bendinelli B, Ricceri F, Sánchez M, Trobajo-Sanmartín C, Jakszyn P, Simeon V, Severi G, Perduca V, Truong T, Ferrari P, Keski-Rahkonen P, Weiderpass E, Eichelmann F, Schulze M, Katzke V, Fortner R, Heath A, Aune D, Harewood R, Dahm C, Llorente A, Gunter M, Murphy N, Lewis S. Identifying metabolomic mediators of the physical activity and colorectal cancer relationship. Cancer Epidemiology Biomarkers & Prevention 2025, of1-of10. PMID: 39883068, DOI: 10.1158/1055-9965.epi-24-1390.Peer-Reviewed Original ResearchPhysical activityPA levelsReduced risk of colorectal cancerAssociated with CRC riskColorectal cancerRisk of colorectal cancerFalse discovery rate correctionColorectal cancer riskCancer prevention interventionsNested case-control studyMetabolomic signaturesCase-control studyCancer relationshipCRC riskBaseline questionnairePA measuresEPIC cohortPreventive interventionsInverse associationPA indexPhosphatidylcholine acyl-alkylReduced riskMediation analysisMetabolomics panelCirculating metabolomeCancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2024
Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case–Control Analysis Within the EPIC Study
Almanza-Aguilera E, Martínez-Huélamo M, López-Hernández Y, Guiñón-Fort D, Guadall A, Cruz M, Perez-Cornago A, Rostgaard-Hansen A, Tjønneland A, Dahm C, Katzke V, Schulze M, Masala G, Agnoli C, Tumino R, Ricceri F, Lasheras C, Crous-Bou M, Sánchez M, Aizpurua-Atxega A, Guevara M, Tsilidis K, Chatziioannou A, Weiderpass E, Travis R, Wishart D, Andrés-Lacueva C, Zamora-Ros R. Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case–Control Analysis Within the EPIC Study. Cancers 2024, 16: 4116. PMID: 39682302, PMCID: PMC11639937, DOI: 10.3390/cancers16234116.Peer-Reviewed Original ResearchProstate cancer riskProstate cancerPCa riskBiomarkers of food intakeMultivariate conditional logistic regression analysisNested case-control analysisAdvanced PCa riskFatal prostate cancerCancer and NutritionConditional logistic regression analysisOverall PCa riskEuropean Prospective InvestigationMetabolite concentrationsCase-control analysisCase-control pairsLogistic regression analysisClinically relevant tumor subtypesMetabolomics approachTumor subtypesProspective InvestigationClinical subtypesCancer riskFood intakeMetabolic alterationsEPIC studyPerturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition
Grenville Z, Noor U, Rinaldi S, Gunter M, Ferrari P, Agnoli C, Amiano P, Catalano A, Chirlaque M, Christakoudi S, Guevara M, Johansson M, Kaaks R, Katzke V, Masala G, Olsen A, Papier K, Sánchez M, Schulze M, Tjønneland A, Tong T, Tumino R, Weiderpass E, Zamora‐Ros R, Key T, Smith‐Byrne K, Schmidt J, Travis R. Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition. International Journal Of Cancer 2024, 156: 943-952. PMID: 39378119, PMCID: PMC11701393, DOI: 10.1002/ijc.35208.Peer-Reviewed Original ResearchConceptsAssociated with advanced prostate cancerAdvanced prostate cancerProstate cancerEuropean Prospective InvestigationMetabolite patternsAssociated with prostate cancer deathMultivariable-adjusted conditional logistic regressionProspective InvestigationPresence of prostate cancerHigh-grade prostate cancerProstate cancer overallProstate cancer riskProstate cancer deathAdvanced-stage diseaseCancer and NutritionFollow-up timeYear of blood collectionProstate cancer diagnosisMetabolite profile changesCase-control pairsConditional logistic regressionCase-control settingBlood metabolomeCancer overallFollow-upFood consumption by degree of food processing and risk of type 2 diabetes mellitus: a prospective cohort analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC)
Dicken S, Dahm C, Ibsen D, Olsen A, Tjønneland A, Louati-Hajji M, Cadeau C, Marques C, Schulze M, Jannasch F, Baldassari I, Manfredi L, de Magistris M, Sánchez M, Castro-Espin C, Palacios D, Amiano P, Guevara M, van der Schouw Y, Boer J, Verschuren W, Sharp S, Forouhi N, Wareham N, Vamos E, Chang K, Vineis P, Heath A, Gunter M, Nicolas G, Weiderpass E, Huybrechts I, Batterham R. Food consumption by degree of food processing and risk of type 2 diabetes mellitus: a prospective cohort analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC). The Lancet Regional Health - Europe 2024, 46: 101043. PMID: 39529810, PMCID: PMC11551512, DOI: 10.1016/j.lanepe.2024.101043.Peer-Reviewed Original ResearchIncident type 2 diabetes mellitusUltra-processed foodsDegree of food processingCancer and NutritionEuropean Prospective InvestigationType 2 diabetes mellitus casesType 2 diabetes mellitusProspective cohort analysisUltra-processed food intakeProspective InvestigationUnprocessed/minimally processed foodsRisk of type 2 diabetes mellitusType 2 diabetes mellitus riskCohort analysisInternational Agency for Research on CancerProcessed foodsNOVA classificationSub-group analysisEstimate associationsCulinary ingredientsDietary questionnaireYear follow-upDietary intakeReference groupBreakfast cerealsTrends in Invasive Melanoma Thickness in Norway, 1983-2019.
Rimal R, Robsahm T, Green A, Ghiasvand R, Rueegg C, Bassarova A, Gjersvik P, Weiderpass E, Aalen O, Møller B, Perrier F, Veierød M. Trends in Invasive Melanoma Thickness in Norway, 1983-2019. Acta Dermato Venereologica 2024, 104: adv26110. PMID: 39221835, DOI: 10.2340/actadv.v104.26110.Peer-Reviewed Original ResearchConceptsLong-term incidence trendsCancer Registry of NorwayIncidence time trendsTumor thicknessCancer RegistryIncidence trendsBirth cohortTime trendsPrevention strategiesMelanoma occurrenceAge groupsMelanoma RegistryT categoryMelanoma thicknessT1 melanomasPathology reportsYounger patientsAnatomical sitesIncreased incidenceMelanomaSex differencesTumorIncidencePatientsMenPre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients
Li J, Baker J, Aglago E, Zhao Z, Jiao L, Freisling H, Hughes D, Eriksen A, Tjønneland A, Severi G, Katzke V, Kaaks R, Schulze M, Masala G, Pala V, Pasanisi F, Tumino R, Padroni L, Vermeulen R, Gram I, Braaten T, Jakszyn P, Sánchez M, Gómez‐Gómez J, Moreno‐Iribas C, Amiano P, Papier K, Weiderpass E, Huybrechts I, Heath A, Schalkwijk C, Jenab M, Fedirko V. Pre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients. International Journal Of Cancer 2024, 155: 1982-1995. PMID: 39057841, DOI: 10.1002/ijc.35114.Peer-Reviewed Original ResearchConceptsAssociated with CRC-specificAdvanced glycation end productsPlasma advanced glycation end productsColorectal cancerCRC-specificOverall mortalityGlycation end productsSoluble receptorCancer patientsIntracellular signaling alterationsMultivariable-adjusted Cox proportional hazards regressionCancer and NutritionCox proportional hazards regressionEuropean Prospective InvestigationFollow-up periodColorectal cancer casesColorectal cancer patientsProportional hazards regressionUltra-performance liquid chromatography mass spectrometryColorectal cancer diagnosisEnzyme-linked immunosorbent assayColorectal cancer survivalProspective InvestigationChronic inflammationSRAGEAssociation of infertility and recurrent pregnancy loss with the risk of dementia
Liang C, Dobson A, Chung H, van der Schouw Y, Sandin S, Weiderpass E, Mishra G. Association of infertility and recurrent pregnancy loss with the risk of dementia. European Journal Of Epidemiology 2024, 39: 785-793. PMID: 38888679, PMCID: PMC11343804, DOI: 10.1007/s10654-024-01135-3.Peer-Reviewed Original ResearchConceptsRisk of dementiaHigher risk of dementiaAssociation of infertilityInternational Collaboration for a Life Course ApproachRecurrent stillbirthHazard ratio of dementiaRisk factors of dementiaChronic disease eventsFactors of dementiaDeath registry dataAssessment of dementiaRisk factorsCause-specific Cox regression modelsInterquartile rangeHigh riskAged careWithin-study correlationsReproductive exposuresRegistry dataCox regression modelsSelf-reportDementiaCourse approachDisease eventsHazard ratioHealthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
Matta K, Viallon V, Botteri E, Peveri G, Dahm C, Nannsen A, Olsen A, Tjønneland A, Elbaz A, Artaud F, Marques C, Kaaks R, Katzke V, Schulze M, Llanaj E, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Derksen J, Nøst T, Sandanger T, Borch K, Quirós J, Castro-Espin C, Sánchez M, Atxega A, Cirera L, Guevara M, Manjer J, Tin Tin S, Heath A, Touvier M, Goldberg M, Weiderpass E, Gunter M, Freisling H, Riboli E, Ferrari P. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort. BMC Medicine 2024, 22: 210. PMID: 38807179, PMCID: PMC11134634, DOI: 10.1186/s12916-024-03362-7.Peer-Reviewed Original ResearchConceptsHealthy lifestyle indexAssociated with all-causeHealthy lifestyle changesEuropean Prospective InvestigationRisk of deathCancer mortalityFollow-up questionnaireAll-causeLifestyle changesProspective InvestigationRate advancement periodsUnhealthy lifestyle changesRisk of noncommunicable diseasesCancer and NutritionCancer-free adultsBody mass indexBackgroundHealthy lifestylesLifestyle behaviorsNutrition CohortLifestyle indexLifestyle ProfilePhysical activityAssociated with mortalityNoncommunicable diseasesChange scoresAssociation between waterpipe smoking and lung cancer: a multicentre case–control study in Iran
Rashidian H, Hadji M, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Marzban M, Rezaianzadeh A, Seyyedsalehi M, Moradi A, Gholipour M, Alizadeh-Navaei R, Freedman N, Malekzadeh R, Etemadi A, Kamangar F, Weiderpass E, Pukkala E, Boffetta P, Zendehdel K. Association between waterpipe smoking and lung cancer: a multicentre case–control study in Iran. Public Health 2024, 231: 166-172. PMID: 38701659, DOI: 10.1016/j.puhe.2024.03.008.Peer-Reviewed Original ResearchOR of lung cancerWaterpipe smokingWaterpipe smokersLung cancerHigher OROdds of lung cancerOdds ratioIncreased risk of lung cancerRisk of lung cancerMulticentre case-control studyConfidence intervalsMultivariate logistic regression modelExposure to waterpipe smokeLung cancer casesLogistic regression modelsCase-control studyGlobal public health concernPublic health concernSquamous cell carcinomaResidual confoundingLung cancer patientsCancer casesInitiate smokingWaterpipeNever-smokers