Featured Publications
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 2022, 375: eabl4292. PMID: 35084937, PMCID: PMC9261115, DOI: 10.1126/science.abl4292.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Effectiveness of vaccinesEffectiveness of vaccinationTotal vaccine effectivenessSARS-CoV-2Household contactsSecond doseCoronavirus 2Household transmissionDelta variantDay 10VaccinationBNT162b2COVID-19InfectionChain binomial modelVaccineDoseImmunityCommunity factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study
Zheng Z, Pitzer VE, Warren JL, Weinberger DM. Community factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study. Science Advances 2021, 7: eabd6421. PMID: 34162556, PMCID: PMC8221622, DOI: 10.1126/sciadv.abd6421.Peer-Reviewed Original ResearchRespiratory syncytial virusEpidemic timingSyncytial virusRSV epidemicsBayesian meta-regression modelTiming of deliveryMaternal vaccinesMeta-regression modelsHospitalization dataLarge burdenEarly epidemicLarger household sizeYoung childrenTransmission dynamicsZip code levelEpidemicCommunity factorsEpidemic spreadFuture studiesVirusProphylaxisMorbidityVaccineFactorsDeclines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries
de Oliveira LH, Shioda K, Valenzuela M, Janusz CB, Rearte A, Sbarra AN, Warren JL, Toscano CM, Weinberger DM, Team M. Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries. Clinical Infectious Diseases 2020, 73: 306-313. PMID: 32448889, PMCID: PMC8516507, DOI: 10.1093/cid/ciaa614.Peer-Reviewed Original ResearchConceptsPneumonia mortalityPneumonia deathsAge groupsIntroduction of PCVPneumococcal conjugate vaccinePediatric immunization programsYears of ageCause pneumoniaMulticountry evaluationPCV introductionConjugate vaccinePostvaccination periodImmunization programsChildren 2Age strataPopulation-level impactMortalityPneumoniaMortality dataStandardized protocolModerate incidenceDeathNational-level mortality dataVaccinePCVAssociation Between the Decline in Pneumococcal Disease in Unimmunized Adults and Vaccine-Derived Protection Against Colonization in Toddlers and Preschool-Aged Children
Weinberger DM, Pitzer VE, Regev-Yochay G, Givon-Lavi N, Dagan R. Association Between the Decline in Pneumococcal Disease in Unimmunized Adults and Vaccine-Derived Protection Against Colonization in Toddlers and Preschool-Aged Children. American Journal Of Epidemiology 2018, 188: 160-168. PMID: 30462150, PMCID: PMC6321804, DOI: 10.1093/aje/kwy219.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseUnimmunized adultsPneumococcal diseaseVaccine-associated immunityVaccine-derived protectionVaccine-targeted serotypesNationwide surveillance studyPrevalence of colonizationUnvaccinated adultsPneumococcal carriagePreschool aged childrenVaccine uptakeColonization prevalenceGroup of childrenVaccination coverageEmergency departmentSurveillance studyDisease ratesTrajectory of declineAge rangeAdultsAged childrenChildrenSerotypesVaccine
2023
Worldwide Index of Serotype-Specific Pneumococcal Antibody Responses (WISSPAR): A curated database of clinical trial data
Perniciaro S, Cooper-Wooton D, Knoll M, Weinberger D. Worldwide Index of Serotype-Specific Pneumococcal Antibody Responses (WISSPAR): A curated database of clinical trial data. Gates Open Research 2023, 7: 109. PMID: 37564746, PMCID: PMC10409981, DOI: 10.12688/gatesopenres.14768.1.Peer-Reviewed Original Research
2022
Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data
Ryman J, Weaver J, Hu T, Weinberger D, Yee K, Sachs J. Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data. Npj Vaccines 2022, 7: 140. PMID: 36344529, PMCID: PMC9640717, DOI: 10.1038/s41541-022-00538-1.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineSerotype-specific IgG concentrationsInvasive pneumococcal diseaseVaccine effectivenessIgG concentrationsPneumococcal diseaseImmune responseAntibody concentrationsProtective antibody concentrationsNext-generation vaccinesPCV13 recipientsConjugate vaccineImmunogenicity dataPCV7PCV13SerotypesVaccineDiseasePlaceboImmunogenicityRecipients
2021
Real-time monitoring of the rollout of pneumococcal conjugate vaccines in rural India using a digital tracking platform
Nagar R, Ambiya M, Dalal S, Bhadauriya P, Abdullah H, Shahnawaz M, Weinberger D. Real-time monitoring of the rollout of pneumococcal conjugate vaccines in rural India using a digital tracking platform. Gates Open Research 2021, 5: 16. DOI: 10.12688/gatesopenres.13206.1.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineBooster doseConjugate vaccineImmunization programsRoutine immunization programPercent of childrenMonths of ageFirst doseThird doseVaccination statusPrimary dosesSecond dosePneumococcal transmissionVaccine programDigital health platformPCV13Vaccine deliveryOnly dosesDoseMaximal benefitVaccineTime pointsRural IndiaDosesHealth platform
2020
Estimating the power to detect a change caused by a vaccine from time series data
Weinberger D, Warren J. Estimating the power to detect a change caused by a vaccine from time series data. Gates Open Research 2020, 4: 27. DOI: 10.12688/gatesopenres.13116.1.Peer-Reviewed Original Research
2013
Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease
Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EA, Feikin DR. Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease. American Journal Of Epidemiology 2013, 178: 1488-1495. PMID: 24013204, PMCID: PMC3813314, DOI: 10.1093/aje/kwt156.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseIPD incidenceCarriage dataProportion of IPDPCV changesNasopharyngeal carriage studyNasopharyngeal pneumococcal carriagePre-PCV7 periodYears of agePCV7 introductionPneumococcal diseaseCarriage prevalenceNonvaccine serotypesPneumococcal carriageVaccine impactInvasive diseaseCarriage studiesHigh-quality surveillance systemsAmerican Indian populationsSerotype dataIncidenceIndian populationMixed effects modelsSerotypesVaccine