Featured Publications
Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries
de Oliveira LH, Shioda K, Valenzuela M, Janusz CB, Rearte A, Sbarra AN, Warren JL, Toscano CM, Weinberger DM, Team M. Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries. Clinical Infectious Diseases 2020, 73: 306-313. PMID: 32448889, PMCID: PMC8516507, DOI: 10.1093/cid/ciaa614.Peer-Reviewed Original ResearchConceptsPneumonia mortalityPneumonia deathsAge groupsIntroduction of PCVPneumococcal conjugate vaccinePediatric immunization programsYears of ageCause pneumoniaMulticountry evaluationPCV introductionConjugate vaccinePostvaccination periodImmunization programsChildren 2Age strataPopulation-level impactMortalityPneumoniaMortality dataStandardized protocolModerate incidenceDeathNational-level mortality dataVaccinePCV
2024
Contact with young children is a major risk factor for pneumococcal colonization in older adults
Wyllie A, Yolda-Carr D, Hislop M, Mbodj S, Wurst L, Waghela P, Alexander-Parrish R, Grant L, Arguedas A, Gessner B, Weinberger D. Contact with young children is a major risk factor for pneumococcal colonization in older adults. FEMS Microbes 2024, 5: xtae032. PMCID: PMC11536760, DOI: 10.1093/femsmc/xtae032.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineOlder adultsContact with childrenContact with young childrenNon-institutionalized individualsHousehold membersPneumococcal conjugate vaccine immunizationAdult household membersHealth QuestionnaireYoung childrenTransmission of pneumococciPneumococcal carriagePneumococcal colonizationEstimated Population-Level Impact of Pneumococcal Conjugate Vaccines Against All-Cause Pneumonia Mortality Among Unvaccinated in 5 Latin American Countries
Prunas O, Shioda K, Toscano C, Bastias M, Valenzuela-Bravo M, Tito J, Warren J, Weinberger D, de Oliveira L. Estimated Population-Level Impact of Pneumococcal Conjugate Vaccines Against All-Cause Pneumonia Mortality Among Unvaccinated in 5 Latin American Countries. The Journal Of Infectious Diseases 2024, 230: e768-e776. PMID: 38502711, PMCID: PMC11481321, DOI: 10.1093/infdis/jiae144.Peer-Reviewed Original ResearchAll-cause pneumoniaPneumonia deathsPneumonia mortalityAge groupsPneumococcal conjugate vaccineProportion of IPD casesInvasive pneumococcal diseaseMulti-country studyIPD casesOlder age groupsPopulation-level impactMortality dataYears of ageInvasive pneumococcal disease casesConjugate vaccinePneumococcal conjugate vaccine introductionEffect of pneumococcal conjugate vaccinesTemporal trendsImpact of pneumococcal conjugate vaccinesUnvaccinated age groupsMortalityEvaluate changesPost-vaccination periodVaccine serotypesNo significant changes
2023
2604. Contact With School-Aged Children is a Major Risk Factor for Pneumococcal Colonization in Older Adults
Wyllie A, Yolda-Carr D, Hislop M, Mbodj S, Kennedy H, McLaughlin M, Wurst L, Waghela P, Peno C, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D. 2604. Contact With School-Aged Children is a Major Risk Factor for Pneumococcal Colonization in Older Adults. Open Forum Infectious Diseases 2023, 10: ofad500.2218. PMCID: PMC10679235, DOI: 10.1093/ofid/ofad500.2218.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineOlder adultsTime pointsRisk factorsPneumococcal colonizationAdult transmissionTransmission of pneumococciMajor risk factorRecent contactYear oldsNon-institutionalized individualsYears of ageGrant/research supportSame time pointsPneumococcal acquisitionConjugate vaccineSchool-Aged ChildrenElevated prevalenceYoung school-age childrenHealth statusYoung contactsSaliva samplesMedical directorsSample adultsPneumococci
2022
Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data
Ryman J, Weaver J, Hu T, Weinberger D, Yee K, Sachs J. Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data. Npj Vaccines 2022, 7: 140. PMID: 36344529, PMCID: PMC9640717, DOI: 10.1038/s41541-022-00538-1.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineSerotype-specific IgG concentrationsInvasive pneumococcal diseaseVaccine effectivenessIgG concentrationsPneumococcal diseaseImmune responseAntibody concentrationsProtective antibody concentrationsNext-generation vaccinesPCV13 recipientsConjugate vaccineImmunogenicity dataPCV7PCV13SerotypesVaccineDiseasePlaceboImmunogenicityRecipients
2021
1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA
Wyllie A, Mbodj S, Yolda-Carr D, Thammavongsa D, Waghela P, Nakahata M, Vega N, York A, Allicock O, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D, Hislop M. 1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA. Open Forum Infectious Diseases 2021, 8: 749-749. PMCID: PMC8689704, DOI: 10.1093/ofid/ofab466.1513.Peer-Reviewed Original ResearchPneumococcal carriageSaliva samplesOlder adultsPreventative public health measuresPneumococcal conjugate vaccineNew Haven areaPublic health measuresPneumococcal acquisitionPneumococcal diseaseConjugate vaccinePneumococcal transmissionStudy enrollmentMedical historyImportant burdenDemonstrate evidenceStreptococcus pneumoniaeHealth measuresMultiple timepointsTime pointsWeeksAdultsCOVID-19 pandemicAgeHigh ratePneumococciReal-time monitoring of the rollout of pneumococcal conjugate vaccines in rural India using a digital tracking platform
Nagar R, Ambiya M, Dalal S, Bhadauriya P, Abdullah H, Shahnawaz M, Weinberger D. Real-time monitoring of the rollout of pneumococcal conjugate vaccines in rural India using a digital tracking platform. Gates Open Research 2021, 5: 16. DOI: 10.12688/gatesopenres.13206.1.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineBooster doseConjugate vaccineImmunization programsRoutine immunization programPercent of childrenMonths of ageFirst doseThird doseVaccination statusPrimary dosesSecond dosePneumococcal transmissionVaccine programDigital health platformPCV13Vaccine deliveryOnly dosesDoseMaximal benefitVaccineTime pointsRural IndiaDosesHealth platform
2015
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data
Weinberger DM, Klugman KP, Steiner CA, Simonsen L, Viboud C. Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data. PLOS Medicine 2015, 12: e1001776. PMID: 25562317, PMCID: PMC4285401, DOI: 10.1371/journal.pmed.1001776.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusPneumococcal pneumoniaRate of hospitalizationPneumococcal diseaseHospitalization dataSeven-valent pneumococcal conjugate vaccineBacterial infectionsRespiratory syncytial virus activityLaboratory-confirmed dataPneumococcal pneumonia hospitalizationsPneumococcal conjugate vaccineIntroduction of PCV7Secondary bacterial infectionState Inpatient DatabasesPoisson regression modelsRSV hospitalizationPCV7 introductionPneumonia hospitalizationsConjugate vaccineInpatient DatabaseSyncytial virusPneumococcal septicemiaPneumonia casesEpidemic timingHospitalization
2011
Serotype replacement in disease after pneumococcal vaccination
Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011, 378: 1962-1973. PMID: 21492929, PMCID: PMC3256741, DOI: 10.1016/s0140-6736(10)62225-8.Peer-Reviewed Original ResearchConceptsNon-vaccine serotypesSerotype replacementPneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineImportant public health benefitsBenefits of vaccinationPublic health benefitsDisease surveillance systemsNVT carriagePneumococcal vaccinationSurveillance biasesConjugate vaccineVaccine serotypesCarriage prevalencePneumococcal serotypesAsymptomatic carriersCarriage dataDiseaseVaccinationHealth benefitsLow invasivenessPrevalenceSerotypesCarriage