The Neuro-APAP Study

This R01 study is conducting in-depth analyses using highly unique data sources from the Danish National Birth Cohort (DNBC) to investigate whether prenatal and postnatal exposures to Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) affect neurodevelopment from infancy through age 18.

An estimated 45-65% of pregnant women reported intake of APAP in the US, but there has been little data on safety for potential health effects in the prenatally exposed offspring. The Society for Maternal-Fetal Medicine and the US Food and Drug Administration have called for a more thorough investigation and better data to guide the safety of APAP use in pregnancy. Our experienced and multidisciplinary team will leverage the rich data collected in the DNBC and records from the Danish population medical registries to investigate the potential effects of APAP exposures on fetal development.