Ma Lab Publications

2024

Estimation of multiple networks with common structures in heterogeneous subgroups.Qin X, Hu J, Ma S, Wu M. J Multivar Anal. 2024 Jul; 2024 Feb 13. PMID: 38433779.
Endocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study.Denic-Roberts H, McAdam J, Sjodin A, Davis M, Jones R, Ward MH, Hoang TD, Ma S, Zhang Y, Rusiecki JA. Sci Total Environ. 2024 Apr 20; 2024 Feb 28. PMID: 38428594.
Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches.Yang BZ, Xiang B, Wang T, Ma S, Li CR. Psychiatry Res. 2024 Apr; 2024 Feb 28. PMID: 38422867.
Hierarchical False Discovery Rate Control for High-dimensional Survival Analysis with Interactions.Liang W, Zhang Q, Ma S. Comput Stat Data Anal. 2024 Apr; 2023 Dec 5. PMID: 38098875.
Information-incorporated sparse hierarchical cancer heterogeneity analysis.Han W, Zhang S, Ma S, Ren M. Stat Med. 2024 Mar 30; 2024 Mar 30. PMID: 38553996.
Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study.Rusiecki JA, McAdam J, Denic-Roberts H, Sjodin A, Davis M, Jones R, Hoang TD, Ward MH, Ma S, Zhang Y. Environ Health. 2024 Mar 19; 2024 Mar 19. PMID: 38504322.

2023

FunctanSNP: an R package for functional analysis of dense SNP data (with interactions).Ren R, Fang K, Zhang Q, Ma S. Bioinformatics. 2023 Dec 1. PMID: 38060266.
Pathological imaging-assisted cancer gene-environment interaction analysis.Fang K, Li J, Zhang Q, Xu Y, Ma S. Biometrics. 2023 Dec; 2023 May 17. PMID: 37132273.
Bi-level structured functional analysis for genome-wide association studies.Wu M, Wang F, Ge Y, Ma S, Li Y. Biometrics. 2023 Dec; 2023 May 7. PMID: 37098961.
Comparative Effectiveness Analysis of Lumpectomy and Mastectomy for Elderly Female Breast Cancer Patients: A Deep Learning-based Big Data Analysis.Wang J, Zhang S, Yi H, Ma S. Yale J Biol Med. 2023 Sep; 2023 Sep 29. PMID: 37781001.
ZINBMM: a general mixture model for simultaneous clustering and gene selection using single-cell transcriptomic data.Li Y, Wu M, Ma S, Wu M. Genome Biol. 2023 Sep 11; 2023 Sep 11. PMID: 37697330.
Two-level Bayesian interaction analysis for survival data incorporating pathway information.Qin X, Ma S, Wu M. Biometrics. 2023 Sep; 2022 Dec 27. PMID: 36524727.
Prior information-assisted integrative analysis of multiple datasets.Wang F, Liang D, Li Y, Ma S. Bioinformatics. 2023 Aug 1. PMID: 37490475.
Aligned deep neural network for integrative analysis with high-dimensional input.Zhang S, Zhang S, Yi H, Ma S. J Biomed Inform. 2023 Aug; 2023 Jun 28. PMID: 37391115.
Robust Bayesian variable selection for gene-environment interactions.Ren J, Zhou F, Li X, Ma S, Jiang Y, Wu C. Biometrics. 2023 Jun; 2022 Apr 16. PMID: 35394058.
Bayesian finite mixture of regression analysis for cancer based on histopathological imaging-environment interactions.Im Y, Huang Y, Tan A, Ma S. Biostatistics. 2023 Apr 14. PMID: 37057611.
HETEROGENEITY ANALYSIS VIA INTEGRATING MULTI-SOURCES HIGH-DIMENSIONAL DATA WITH APPLICATIONS TO CANCER STUDIES.Zhong T, Zhang Q, Huang J, Wu M, Ma S. Stat Sin. 2023 Apr. PMID: 38037567.
Unified model-free interaction screening via CV-entropy filter.Xiong W, Chen Y, Ma S. Comput Stat Data Anal. 2023 Apr; 2022 Dec 28. PMID: 36910335.
Gene-environment interaction analysis via deep learning.Wu S, Xu Y, Zhang Q, Ma S. Genet Epidemiol. 2023 Apr; 2023 Feb 19. PMID: 36807383.
SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.Jaycox JR, Lucas C, Yildirim I, Dai Y, Wang EY, Monteiro V, Lord S, Carlin J, Kita M, Buckner JH, Ma S, Campbell M, Ko A, Omer S, Lucas CL, Speake C, Iwasaki A, Ring AM. Nat Commun. 2023 Mar 9; 2023 Mar 9. PMID: 36894554.
Human disease clinical treatment network for the elderly: analysis of the medicare inpatient length of stay and readmission data.Mei H, Jia R, Qiao G, Lin Z, Ma S. Biometrics. 2023 Mar; 2021 Sep 16. PMID: 34411297.
A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics Data.Xiao Z, Xingjie S, Yiming L, Xu L, Ma S. J Comput Graph Stat. 2023; 2023 Feb 6. PMID: 38009111.
Spatio-temporally smoothed deep survival neural network.Li Y, Liang D, Ma S, Ma C. J Biomed Inform. 2023 Jan; 2022 Dec 1. PMID: 36462600.

2022

Hierarchical cancer heterogeneity analysis based on histopathological imaging features.Ren M, Zhang Q, Zhang S, Zhong T, Huang J, Ma S. Biometrics. 2022 Dec; 2021 Aug 22. PMID: 34390584.
Multidimensional molecular measurements-environment interaction analysis for disease outcomes.Xu Y, Wu M, Ma S. Biometrics. 2022 Dec; 2021 Aug 1. PMID: 34213006.
A high-efficiency differential expression method for cancer heterogeneity using large-scale single-cell RNA-sequencing data.Yuan X, Ma S, Fa B, Wei T, Ma Y, Wang Y, Lv W, Zhang Y, Zheng J, Chen G, Sun J, Yu Z. Front Genet. 2022; 2022 Nov 29. PMID: 36523772.
A Linguistic Analysis of News Coverage of E-Healthcare in China with a Heterogeneous Graphical Model.Liu M, Fan X, Ma S. Entropy (Basel). 2022 Oct 29; 2022 Oct 29. PMID: 36359647.
A tree-based gene-environment interaction analysis with rare features.Liu M, Zhang Q, Ma S. Stat Anal Data Min. 2022 Oct; 2022 Mar 1. PMID: 38046814.
Replicability in cancer omics data analysis: measures and empirical explorations.Wang J, Liang H, Zhang Q, Ma S. Brief Bioinform. 2022 Sep 20. PMID: 35876281.
Survival Analysis with High-Dimensional Omics Data Using a Threshold Gradient Descent Regularization-Based Neural Network Approach.Fan Y, Zhang S, Ma S. Genes (Basel). 2022 Sep 19; 2022 Sep 19. PMID: 36140842.
A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members.Zhuo H, Huang H, Sjodin A, Jin L, Ma S, Denic-Roberts H, Warren JL, Jones R, Davis M, Sun P, Yu H, Ward MH, Udelsman R, Zhang Y, Rusiecki JA. Environ Res. 2022 Sep; 2022 May 2. PMID: 35504340.
HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART.Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. JCI Insight. 2022 Jul 8; 2022 Jul 8. PMID: 35801589.
Sparse group variable selection for gene-environment interactions in the longitudinal study.Zhou F, Lu X, Ren J, Fan K, Ma S, Wu C. Genet Epidemiol. 2022 Jul; 2022 Jun 29. PMID: 35766061.
Changes in prostate cancer survival among insured patients in relation to USPSTF screening recommendations.Kim IE Jr, Kim DD, Kim S, Ma S, Jang TL, Singer EA, Ghodoussipour S, Kim IY. BMC Urol. 2022 Jun 25; 2022 Jun 25. PMID: 35752822.
Information-incorporated Gaussian graphical model for gene expression data.Yi H, Zhang Q, Lin C, Ma S. Biometrics. 2022 Jun; 2021 Feb 12. PMID: 33527365.
Gaussian graphical model-based heterogeneity analysis via penalized fusion.Ren M, Zhang S, Zhang Q, Ma S. Biometrics. 2022 Jun; 2021 Feb 5. PMID: 33501648.
GEInfo: an R package for gene-environment interaction analysis incorporating prior information.Wang X, Liu H, Ma S. Bioinformatics. 2022 May 26. PMID: 35485739.
iSFun: an R package for integrative dimension reduction analysis.Fang K, Ren R, Zhang Q, Ma S. Bioinformatics. 2022 May 26. PMID: 35441661.
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination.Lu-Culligan A, Tabachnikova A, Pérez-Then E, Tokuyama M, Lee HJ, Lucas C, Silva Monteiro V, Miric M, Brache V, Cochon L, Muenker MC, Mohanty S, Huang J, Kang I, Dela Cruz C, Farhadian S, Campbell M, Yildirim I, Shaw AC, Ma S, Vermund SH, Ko AI, Omer SB, Iwasaki A. PLoS Biol. 2022 May; 2022 May 24. PMID: 35609110.
Network-based cancer heterogeneity analysis incorporating multi-view of prior information.Li Y, Xu S, Ma S, Wu M. Bioinformatics. 2022 May 13. PMID: 35561185.
Biclustering analysis of functionals via penalized fusion.Fang K, Chen Y, Ma S, Zhang Q. J Multivar Anal. 2022 May; 2021 Oct 29. PMID: 36817965.
Integrative functional linear model for genome-wide association studies with multiple traits.Li Y, Wang F, Wu M, Ma S. Biostatistics. 2022 Apr 13. PMID: 33040145.
Bayesian hierarchical finite mixture of regression for histopathological imaging-based cancer data analysis.Im Y, Huang Y, Huang J, Ma S. Stat Med. 2022 Mar 15; 2022 Jan 13. PMID: 35028949.
Analysis of cancer omics data: a selective review of statistical techniques.Ma C, Wu M, Ma S. Brief Bioinform. 2022 Mar 10. PMID: 35039832.
Gene-environment interaction identification via penalized robust divergence.Ren M, Zhang S, Ma S, Zhang Q. Biom J. 2022 Mar; 2021 Nov 1. PMID: 34725857.
Comparative Analysis of Social Support in Online Health Communities Using a Word Co-Occurrence Network Analysis Approach.Liu M, Zou X, Chen J, Ma S. Entropy (Basel). 2022 Jan 25; 2022 Jan 25. PMID: 35205469.
Default risk prediction and feature extraction using a penalized deep neural network.Lin C, Qiao N, Zhang W, Li Y, Ma S. Stat Comput. 2022; 2022 Sep 15. PMID: 36124203.

2021

Gene-gene interaction analysis incorporating network information via a structured Bayesian approach.Qin X, Ma S, Wu M. Stat Med. 2021 Dec 20; 2021 Sep 20. PMID: 34542187.
Histopathological imaging-based cancer heterogeneity analysis via penalized fusion with model averaging.He B, Zhong T, Huang J, Liu Y, Zhang Q, Ma S. Biometrics. 2021 Dec; 2020 Aug 29. PMID: 32822084.
An emulated target trial analysis based on Medicare data suggested non-inferiority of Dabigatran versus Rivaroxaban.Mei H, Wang J, Ma S. J Clin Epidemiol. 2021 Nov; 2021 Jul 14. PMID: 34271110.
GEInter: an R package for robust gene-environment interaction analysis.Wu M, Qin X, Ma S. Bioinformatics. 2021 Oct 25. PMID: 33961050.
HeteroGGM: an R package for Gaussian graphical model-based heterogeneity analysis.Ren M, Zhang S, Zhang Q, Ma S. Bioinformatics. 2021 Sep 29. PMID: 33638346.
Assisted differential network analysis for gene expression data.Yi H, Ma S. Genet Epidemiol. 2021 Sep; 2021 Jun 26. PMID: 34174112.
Marginal false discovery rate for a penalized transformation survival model.Liang W, Ma S, Lin C. Comput Stat Data Anal. 2021 Aug; 2021 Apr 2. PMID: 34393307.
Biomarker-guided heterogeneity analysis of genetic regulations via multivariate sparse fusion.Zhang S, Hu X, Luo Z, Jiang Y, Sun Y, Ma S. Stat Med. 2021 Jul 30; 2021 Apr 27. PMID: 33906263.
DReSS: a method to quantitatively describe the influence of structural perturbations on state spaces of genetic regulatory networks.Yin Z, Guo B, Ma S, Sun Y, Mi Z, Zheng Z. Brief Bioinform. 2021 Jul 20. PMID: 33313791.
Kynurenic acid may underlie sex-specific immune responses to COVID-19.Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Sci Signal. 2021 Jul 6; 2021 Jul 6. PMID: 34230210.
Diverse functional autoantibodies in patients with COVID-19.Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR, Liu F, Zhou T, Israelow B, Wong P, Coppi A, Lucas C, Silva J, Oh JE, Song E, Perotti ES, Zheng NS, Fischer S, Campbell M, Fournier JB, Wyllie AL, Vogels CBF, Ott IM, Kalinich CC, Petrone ME, Watkins AE, Dela Cruz C, Farhadian SF, Schulz WL, Ma S, Grubaugh ND, Ko AI, Iwasaki A, Ring AM. Nature. 2021 Jul; 2021 May 19. PMID: 34010947.
Assisted estimation of gene expression graphical models.Yi H, Zhang Q, Sun Y, Ma S. Genet Epidemiol. 2021 Jun; 2021 Feb 1. PMID: 33527531.
Vertical integration methods for gene expression data analysis.Wu M, Yi H, Ma S. Brief Bioinform. 2021 May 20. PMID: 32793970.
Human disease clinical treatment network for the elderly: The analysis of medicare inpatient length of stay data.Mei H, Jia R, Qiao G, Lin Z, Ma S. Stat Med. 2021 Apr 15; 2021 Feb 2. PMID: 33527492.
Integrative sparse partial least squares.Liang W, Ma S, Zhang Q, Zhu T. Stat Med. 2021 Apr; 2021 Feb 8. PMID: 33559203.
A likelihood ratio test on temporal trends in age-period-cohort models with applications to the disparities of heart disease mortality among US populations and comparison with Japan.Fu W, Ding J, Gao K, Ma S, Tian L. Stat Med. 2021 Feb 10; 2020 Nov 18. PMID: 33210329.
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.Alvarado-Cruz I, Mahmoud M, Khan M, Zhao S, Oeck S, Meas R, Clairmont K, Quintana V, Zhu Y, Porciuncula A, Wyatt H, Ma S, Shyr Y, Kong Y, LoRusso PM, Laverty D, Nagel ZD, Schalper KA, Krauthammer M, Sweasy JB. Biochem Pharmacol. 2021 Feb; 2020 Dec 4. PMID: 33285109.
Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality.Silva J, Lucas C, Sundaram M, Israelow B, Wong P, Klein J, Tokuyama M, Lu P, Venkataraman A, Liu F, Mao T, Oh JE, Park A, Casanovas-Massana A, Vogels CBF, Muenker MC, Zell J, Fournier JB, Campbell M, Chiorazzi M, Fuentes ER, Petrone ME, Kalinich CC, Ott IM, Watkins A, Moore AJ, Nakahata M, Farhadian S, Cruz CD, Ko AI, Schulz WL, Ring A, Ma S, Omer S, Wyllie AL, Iwasaki A. medRxiv. 2021 Jan 10; 2021 Jan 10. PMID: 33442706.
Integration of Proteomics and Other Omics Data.Wu M, Jiang Y, Ma S. Methods Mol Biol. 2021. PMID: 34236669.
Gene-Environment Interaction: A Variable Selection Perspective.Zhou F, Ren J, Lu X, Ma S, Wu C. Methods Mol Biol. 2021. PMID: 33733358.
Regional Adoption of Commercial Gene Expression Testing for Prostate Cancer.Leapman MS, Wang R, Ma S, Gross CP, Ma X. JAMA Oncol. 2021 Jan 1. PMID: 33237277.

2020

Evaluation of Survival Outcomes of Endovascular Versus Open Aortic Repair for Abdominal Aortic Aneurysms with a Big Data Approach.Mei H, Xu Y, Wang J, Ma S. Entropy (Basel). 2020 Nov 30; 2020 Nov 30. PMID: 33265931.
Associations of physical activity and screen time with suboptimal health status and sleep quality among Chinese college freshmen: A cross-sectional study.Ma C, Zhou L, Xu W, Ma S, Wang Y. PLoS One. 2020; 2020 Sep 18. PMID: 32946516.
Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling.Zhang S, Fan Y, Zhong T, Ma S. Sci Rep. 2020 Sep 14; 2020 Sep 14. PMID: 32929170.
Kynurenic acid underlies sex-specific immune responses to COVID-19.Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. medRxiv. 2020 Sep 8; 2020 Sep 8. PMID: 32935119.
Healthcare, Insurance, and Medical Expenditure of the Floating Population in Beijing, China.Ma C, Zhang Y, Li Y, Wang Y, Jiang Y, Wang X, Ma S. Front Public Health. 2020; 2020 Aug 6. PMID: 32850597.
Tests for regression coefficients in high dimensional partially linear models.Liu Y, Zhang S, Ma S, Zhang Q. Stat Probab Lett. 2020 Aug; 2020 Apr 9. PMID: 32431467.
An integrative sparse boosting analysis of cancer genomic commonality and difference.Sun Y, Sun Z, Jiang Y, Li Y, Ma S. Stat Methods Med Res. 2020 May; 2019 Jul 7. PMID: 31282286.
Human disease cost network analysis.Ma C, Li Y, Shia B, Ma S. Stat Med. 2020 Apr 30; 2020 Jan 11. PMID: 31925970.
Racial differences in testicular cancer in the United States: descriptive epidemiology.Li Y, Lu Q, Wang Y, Ma S. BMC Cancer. 2020 Apr 6; 2020 Apr 6. PMID: 32252689.
Structured Analysis of the High-dimensional FMR Model.Liu M, Zhang Q, Fang K, Ma S. Comput Stat Data Anal. 2020 Apr; 2019 Nov 13. PMID: 32863493.
Structured sparse logistic regression with application to lung cancer prediction using breath volatile biomarkers.Zhang X, Zhang Q, Wang X, Ma S, Fang K. Stat Med. 2020 Mar 30; 2019 Dec 27. PMID: 31880351.
Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population-based case-control study in Connecticut.Luo J, Li H, Deziel NC, Huang H, Zhao N, Ma S, Ni X, Udelsman R, Zhang Y. Environ Res. 2020 Mar; 2019 Dec 6. PMID: 31918310.
Identification of gene-environment interactions with marginal penalization.Zhang S, Xue Y, Zhang Q, Ma C, Wu M, Ma S. Genet Epidemiol. 2020 Mar; 2019 Nov 14. PMID: 31724772.
Structured gene-environment interaction analysis.Wu M, Zhang Q, Ma S. Biometrics. 2020 Mar; 2019 Oct 9. PMID: 31424088.
Semiparametric Bayesian variable selection for gene-environment interactions.Ren J, Zhou F, Li X, Chen Q, Zhang H, Ma S, Jiang Y, Wu C. Stat Med. 2020 Feb 28; 2019 Dec 21. PMID: 31863500.
Polybrominated Diphenyl Ethers, Polybrominated Biphenyls, and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study.Huang H, Sjodin A, Chen Y, Ni X, Ma S, Yu H, Ward MH, Udelsman R, Rusiecki J, Zhang Y. Am J Epidemiol. 2020 Feb 28. PMID: 31742588.
Integrating approximate single factor graphical models.Fan X, Fang K, Ma S, Zhang Q. Stat Med. 2020 Jan 30; 2019 Nov 20. PMID: 31749227.
Dietary patterns and thyroid cancer risk: a population-based case-control study.Liang J, Zhao N, Zhu C, Ni X, Ko J, Huang H, Ma S, Udelsman R, Zhang Y. Am J Transl Res. 2020; 2020 Jan 15. PMID: 32051747.
Smooth and Locally Sparse Estimation for Multiple-Output Functional Linear Regression.Fang K, Zhang X, Ma S, Zhang Q. J Stat Comput Simul. 2020; 2019 Oct 22. PMID: 33012883.
Promoting sign consistency in the cure model estimation and selection.Shi X, Ma S, Huang Y. Stat Methods Med Res. 2020 Jan; 2019 Jan 2. PMID: 30600776.

2019

NCutYX: a package for clustering analysis of multilayer omics data.Teran Hidalgo SJ, Wu M, Ma S. Bioinformatics. 2019 Nov 15; 2019 Nov 15. PMID: 31730176.
Population-Based Brain Tumor Survival Analysis via Spatial- and Temporal-Smoothing.Ma C, Xue Y, Ma S. Cancers (Basel). 2019 Nov 5; 2019 Nov 5. PMID: 31694302.
Robust semiparametric gene-environment interaction analysis using sparse boosting.Wu M, Ma S. Stat Med. 2019 Oct 15; 2019 Jul 29. PMID: 31359454.
Horizontal and vertical integrative analysis methods for mental disorders omics data.Wang S, Shi X, Wu M, Ma S. Sci Rep. 2019 Sep 17; 2019 Sep 17. PMID: 31530853.
Robust identification of gene-environment interactions for prognosis using a quantile partial correlation approach.Xu Y, Wu M, Zhang Q, Ma S. Genomics. 2019 Sep; 2018 Jul 17. PMID: 30009922.
Integrative Analysis of Cancer Omics Data for Prognosis Modeling.Wang S, Wu M, Ma S. Genes (Basel). 2019 Aug 9; 2019 Aug 9. PMID: 31405076.
Penalized integrative semiparametric interaction analysis for multiple genetic datasets.Li Y, Li R, Lin C, Qin Y, Ma S. Stat Med. 2019 Jul 30; 2019 Apr 16. PMID: 30993736.
Assisted graphical model for gene expression data analysis.Fan X, Fang K, Ma S, Wang S, Zhang Q. Stat Med. 2019 Jun 15; 2019 Mar 10. PMID: 30854706.
Medical expenditure for middle-aged and elderly in Beijing.Ma C, Jiang Y, Li Y, Zhang Y, Wang X, Ma S, Wang Y. BMC Health Serv Res. 2019 Jun 7; 2019 Jun 7. PMID: 31174516.
Identifying gene-environment interactions incorporating prior information.Wang X, Xu Y, Ma S. Stat Med. 2019 Apr 30; 2019 Jan 13. PMID: 30637789.
Histopathological Imaging⁻Environment Interactions in Cancer Modeling.Xu Y, Zhong T, Wu M, Ma S. Cancers (Basel). 2019 Apr 24; 2019 Apr 24. PMID: 31022926.

2017

Identification of Prognostic Genes and Pathways in Lung Adenocarcinoma Using a Bayesian Approach.Jiang Y, Huang Y, Du Y, Zhao Y, Ren J, Ma S, Wu C. Cancer Inform. 2017; 2020 Dec 10. PMID: 33354107.