Despite the challenges of COVID-19, Yale-PCCSM section members continued their work on scientific papers

Despite the challenges of COVID-19, Yale Pulmonary, Critical Care & Sleep Medicine (Yale-PCCSM) section members at Yale School of Medicine (YSM) have authored more than 80 papers in recent months. Selected research papers in which either the first or last author is a Yale-PCCSM section member are highlighted here. Hannah Oakland and Jacqueline Geer are fellows.

· Physiological Traits and Adherence to Therapy of Sleep Apnea in Individuals with Coronary Artery Disease. Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Am J Respir Crit Care Med. 2021 June 22; 2021 June 22. PMID: 34156917.

· Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes. Shin HJ, Kim SH, Park HJ, Shin MS, Kang I, Kang MJ. Aging Cell. 2021 Jun 4; 2021 Jun 4. PMID: 34087956.

· Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Eur Respir J. 2021 Jun 3; 2021 Jun 3. PMID: 34083402.

· Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons. Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE, Ferrante LE. Crit Care Med. 2021 Jun 1. PMID: 33497167.

· The Arterial Load and Right Ventricular-Vascular Coupling in Pulmonary Hypertension. Oakland HT, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. J Appl Physiol (1985). 2021 May 27; 2021 May 27. PMID: 34043473.

· Integrated Single Cell Atlas of Endothelial Cells of the Human Lung. Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Circulation. 2021 May 25; 2021 May 25. PMID: 34030460.

· G2S3: A gene graph-based imputation method for single-cell RNA sequencing data. Wu W, Liu Y, Dai Q, Yan X, Wang Z. PLoS Comput Biol. 2021 May 18; 2021 May 18. PMID: 34003861.

· Surveillance of adverse drug events associated with tocilizumab in hospitalized veterans with coronavirus disease 2019 (COVID-19) to inform patient safety and pandemic preparedness. Datta R, Barrett A, Burk M, Salone C, Au A, Cunningham F, Fisher A, Dembry LM, Akgün KM. Infect Control Hosp Epidemiol. 2021 May 14; 2021 May 14. PMID: 33985598.

· SPLUNC1: a novel marker of cystic fibrosis exacerbations. Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 May 6; 2021 May 6. PMID: 33958427.

· PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology. Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ. Am J Respir Cell Mol Biol. 2021 May. PMID: 33577398.

· Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage. Geer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK, Sheth KN. Stroke. 2021 May; 2021 Apr 8. PMID: 33827242.

· Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Chen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Respir Res. 2021 Apr 26; 2021 Apr 26. PMID: 33902571.

· Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis. Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.

· Elevated IL-15 concentrations in the sarcoidosis lung is independent of granuloma burden and disease phenotypes. Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2021 Apr 14; 2021 Apr 14. PMID: 33851886.

· Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study. Bade BC, Gan G, Li F, Lu L, Tanoue L, Silvestri GA, Irwin ML. BMC Cancer. 2021 Apr 1; 2021 Apr 1. PMID: 33794808.

· Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Chest. 2021 Apr; 2020 Nov 18. PMID: 33217418.

· The Association Between Hospital End-of-Life Care Quality and the Care Received Among Patients With Heart Failure. Feder SL, Tate J, Ersek M, Krishnan S, Chaudhry SI, Bastian LA, Rolnick J, Kutney-Lee A, Akgün KM. J Pain Symptom Manage. 2021 Apr; 2020 Sep 12. PMID: 32931904.

Reviews/editorials

· Genetic Variants of SARS-CoV-2: What do we know so far? Jamil S, Shafazand S, Pasnick S, Carlos WG, Maves R, Dela Cruz C. Am J Respir Crit Care Med. 2021 May 10; 2021 May 10. PMID: 33970826.

· Sleep during lockdown. Kryger MH. Sleep Health. 2021 May 8; 2021 May 8. PMID: 33975818.

· Showing a dream. Kryger MH. Sleep Health. 2021 Apr; 2021 Mar 5. PMID: 33685831

· 2020 Updated Asthma Guidelines: Bronchial thermoplasty in the management of asthma. Castro M, Chupp G. J Allergy Clin Immunol. 2021 May; 2021 Mar 2. PMID: 33667476.

The Section of Pulmonary, Critical Care and Sleep Medicine is one of the eleven sections within YSM’s Department of Internal Medicine. To learn more about Yale-PCCSM, visit PCCSM’s website, or follow them on Facebook and Twitter.