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Yale scientists have engineered natural killer cells that eliminate solid tumors in mouse models. The study may lead to a simpler, “off the shelf” immunotherapy for hard-to-treat cancers.

A team of Yale researchers, led by Zeynep Erson-Omay, PhD, assistant professor in the Department of Neurosurgery, and Murat Gunel, MD, chair of the Department of Neurosurgery, Sterling Professor of Neurosurgery, and professor of genetics and of neuroscience at Yale School of Medicine, has identified a previously unrecognized molecular subgroup of meningiomas defined by recurrent gene fusions involving FOS and FOSB genes.

Intracranial aneurysms (IAs) are pathologic dilatations of cerebral arteries with the potential for rupture and subarachnoid hemorrhage (SAH). While inflammation is implicated in IA pathogenesis, the precise immune regulatory mechanisms underlying IA stability, growth, and rupture remain poorly defined.

The hospital’s annual Benefit, to be held at Greenwich Country Club, will recognize neurosurgeons Murat Günel, MD, and Zion Zibly, MD, whose transformative work in the community has been enhanced by Mrs. Netter’s philanthropic leadership.

The interdisciplinary research project aims to leverage state-of-the-art technologies and cross-departmental expertise to develop large brain models that will serve as the basis for personalized, circuit-based therapies.

Yale researchers may have found a treatment target for a spectrum of genetic disorders that lead to brain malformations, seizures, and intellectual disability.

Rebecca Starble and Danielle Miyagishima

The American Heart Association has honored Daniela Renedo, MD a postdoctoral fellow in the departments of Neurosurgery and Neurology, with the Stroke Basic Science Award for excellence in cerebrovascular disease research.