2023
Residential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metrics
2022
Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsPrenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2020
Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women
Deziel NC, Warren JL, Huang H, Zhou H, Sjodin A, Zhang Y. Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women. Environmental Research 2020, 192: 110333. PMID: 33068584, PMCID: PMC7736223, DOI: 10.1016/j.envres.2020.110333.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerThyroid cancerPCBs/OCPsOdds ratioSubsequent thyroid cancer riskMulti-pollutant modelingSerum Polychlorinated BiphenylsBody mass indexConfidence intervalsThyroid cancer riskThyroid cancer incidenceEarly life exposureEnvironmental risk factorsSingle-pollutant modelsLogistic regression modelsIsotope dilution high-resolution mass spectrometryMass indexTumor sizeCancer incidenceRisk factorsConnecticut womenFamily historyMulti-pollutant analysisCancer riskThyroid hormone disruptorsBirth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesPrenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasma
2018
Cell phone use and risk of thyroid cancer: a population-based case–control study in Connecticut
Luo J, Deziel NC, Huang H, Chen Y, Ni X, Ma S, Udelsman R, Zhang Y. Cell phone use and risk of thyroid cancer: a population-based case–control study in Connecticut. Annals Of Epidemiology 2018, 29: 39-45. PMID: 30446214, PMCID: PMC6344271, DOI: 10.1016/j.annepidem.2018.10.004.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyCase-control studyThyroid cancerThyroid microcarcinomaOdds ratioUnconditional logistic regressionPopulation-based controlsThyroid cancer casesWarrants further investigationCancer casesSuggestive increaseElevated riskCell phone useSignificant associationCancerLogistic regressionMicrocarcinomaMore frequent usersConfidence intervalsRiskFrequent usersPhone useFurther investigationAssociationHoursA case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women
Deziel NC, Yi H, Stapleton HM, Huang H, Zhao N, Zhang Y. A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women. BMC Cancer 2018, 18: 637. PMID: 29871608, PMCID: PMC5989427, DOI: 10.1186/s12885-018-4553-9.Peer-Reviewed Original ResearchConceptsCase-control studyThyroid cancer riskPFR exposureThyroid cancerPFR metabolitesOdds ratioCancer riskPapillary thyroid cancer casesUrinary biomarker measurementsTime of diagnosisLarger tumor sizeCancer case-control studySpot urine samplesThyroid cancer casesPapillary thyroid cancer riskTumor sizePotential confoundersThyroid hormone regulationUrinary concentrationsCancer casesMultiple linear regression analysisFemale controlsLinear regression analysisBackgroundGrowing evidenceBiomarker measurements
2015
Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma
DellaValle CT, Deziel NC, Jones RR, Colt JS, De Roos AJ, Cerhan JR, Cozen W, Severson RK, Flory AR, Morton LM, Ward MH. Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma. Cancer Causes & Control 2015, 27: 1-13. PMID: 26573845, PMCID: PMC5358542, DOI: 10.1007/s10552-015-0660-y.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaT-cell lymphomaOdds ratioCell lymphomaRisk of NHLNational Cancer Institute's Surveillance EpidemiologyMulticenter case-control studyB-cell lymphoma subtypesUnconditional logistic regressionCase-control studyConfidence intervalsHighest tertileLowest tertileHistologic typeSurveillance EpidemiologyNHL overallLymphoma subtypesWhite raceElevated riskSecondary aimConclusionOur resultsLymphomaOlder ageTertileLogistic regression
2014
Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia
Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler P, Ward MH, Metayer C. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environmental Research 2014, 133: 388-395. PMID: 24948546, PMCID: PMC4119528, DOI: 10.1016/j.envres.2014.04.033.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaOdds ratioPopulation-based case-control studyDiagnosis/reference datePAH exposureRisk of childhoodConfidence intervalsCase-control studyResidential dustVacuum dustLog-transformed concentrationsLogistic regressionProbable human carcinogenHigh volume small surface samplerDemographic characteristicsResidential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia in California
Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. Residential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia in California. Environmental Health Perspectives 2014, 122: 1110-1116. PMID: 24911217, PMCID: PMC4181922, DOI: 10.1289/ehp.1307602.Peer-Reviewed Original ResearchConceptsOdds ratioChildhood acute lymphoblastic leukemiaBirth certificate controlsNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyYears of ageChildhood Leukemia StudyRace/ethnicityDate of birthLymphoblastic leukemiaLogistic regressionLeukemia StudyAdditional studiesHigh volume small surface samplerBDE-203House dustCommon PBDEsPositive associationBDE-207AssociationBiological measuresRiskBDE-99BDE-196