Xiaoling Li, PhD
Associate Research ScientistDownloadHi-Res Photo
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Titles
Associate Research Scientist
Associate Research Scientist, Urology
Departments & Organizations
- Mu Lab
Education & Training
- Postdoc Researcher
- UT Southwestern Medical Center
- PhD
- Zhejiang University, Life Sciences Institute/Cell Biology
Research
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Overview
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiaoling Li's published research.
Ping Mu, PhD
Su Deng, PhD
Yaru Xu
Siyuan Cheng
Yuyin Jiang
Publications
Featured Publications
Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Li X, Wang Y, Deng S, Zhu G, Wang C, Johnson N, Zhang Z, Tirado C, Xu Y, Metang L, Gonzalez J, Mukherji A, Ye J, Yang Y, Peng W, Tang Y, Hofstad M, Xie Z, Yoon H, Chen L, Liu X, Chen S, Zhu H, Strand D, Liang H, Raj G, He H, Mendell J, Li B, Wang T, Mu P. Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer. Cancer Cell 2023, 41: 1427-1449.e12. PMID: 37478850, PMCID: PMC10530398, DOI: 10.1016/j.ccell.2023.06.010.Peer-Reviewed Original ResearchCitationsAltmetricLoss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
Zhang Z, Zhou C, Li X, Barnes S, Deng S, Hoover E, Chen C, Lee Y, Zhang Y, Wang C, Metang L, Wu C, Tirado C, Johnson N, Wongvipat J, Navrazhina K, Cao Z, Choi D, Huang C, Linton E, Chen X, Liang Y, Mason C, de Stanchina E, Abida W, Lujambio A, Li S, Lowe S, Mendell J, Malladi V, Sawyers C, Mu P. Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation. Cancer Cell 2020, 37: 584-598.e11. PMID: 32220301, PMCID: PMC7292228, DOI: 10.1016/j.ccell.2020.03.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAndrogen AntagonistsAnimalsApoptosisBiomarkers, TumorCell ProliferationChromatinDNA HelicasesDNA-Binding ProteinsDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHigh-Throughput Screening AssaysHumansMaleMiceProstatic Neoplasms, Castration-ResistantReceptors, AndrogenRNA, Small InterferingTranscription FactorsTumor Cells, CulturedXenograft Model Antitumor Assays
2026
Editorial: APOBEC and ADAR in oncogenesis: from molecular mechanisms to therapeutic targets
Li X, Wang Y, Mu P. Editorial: APOBEC and ADAR in oncogenesis: from molecular mechanisms to therapeutic targets. Frontiers In Genetics 2026, 17: 1827626. PMID: 42039701, PMCID: PMC13105454, DOI: 10.3389/fgene.2026.1827626.Commentaries, Editorials and LettersAltmetricA dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR
Yi Y, Li Y, Wang R, Yu X, Liu Q, Yum C, Zhang Y, Qiao Y, Szczepanski A, Wu S, Li Q, Fazli L, Shen J, Wang X, Li X, Mu P, Schaeffer E, Hundley H, Niu H, Chinnaiyan A, Wang L, Shi J, Jin J, Dong X, Zhao W, Chen K, Cao Q. A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR. Nature Communications 2026, 17: 4421. PMID: 41882000, PMCID: PMC13184275, DOI: 10.1038/s41467-026-71207-3.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Lineage plasticity and histological transformation: tumor histology as a spectrum
Li X, Gardner E, Molina-Pinelo S, Wilhelm C, Mu P, Quintanal-Villalonga Á. Lineage plasticity and histological transformation: tumor histology as a spectrum. Cell Research 2025, 35: 803-823. PMID: 41023204, PMCID: PMC12589604, DOI: 10.1038/s41422-025-01180-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2024
Restoring our ubiquitination machinery to overcome resistance in cancer therapy
Li X, Mu P. Restoring our ubiquitination machinery to overcome resistance in cancer therapy. Oncoscience 2024, 11: 43-44. PMID: 38711948, PMCID: PMC11073315, DOI: 10.18632/oncoscience.600.Commentaries, Editorials and LettersCitationsAltmetricZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Xu Y, Yang Y, Wang Z, Sjostrom M, Jiang Y, Tang Y, Cheng S, Deng S, Wang C, Gonzalez J, Johnson N, Li X, Li X, Metang L, Mukherji A, Xu Q, Tirado C, Wainwright G, Yu X, Barnes S, Hofstad M, Chen Y, Zhu H, Hanker A, Raj G, Zhu G, He H, Wang Z, Arteaga C, Liang H, Feng F, Wang Y, Wang T, Mu P. ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Cancer Discovery 2024, 14: 1496-1521. PMID: 38591846, PMCID: PMC11285331, DOI: 10.1158/2159-8290.cd-23-0539.Peer-Reviewed Original ResearchCitationsAltmetric
2023
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Rodriguez Tirado C, Wang C, Li X, Deng S, Gonzalez J, Johnson N, Xu Y, Metang L, Sundar Rajan M, Yang Y, Yin Y, Hofstad M, Raj G, Zhang S, Lemoff A, He W, Fan J, Wang Y, Wang T, Mu P. UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. Oncogene 2023, 43: 265-280. PMID: 38030789, PMCID: PMC10798893, DOI: 10.1038/s41388-023-02890-5.Peer-Reviewed Original ResearchCitationsAltmetricThe Critical Interplay of CAF Plasticity and Resistance in Prostate Cancer.
Li X, Mu P. The Critical Interplay of CAF Plasticity and Resistance in Prostate Cancer. Cancer Research 2023, 83: 2990-2992. PMID: 37504898, DOI: 10.1158/0008-5472.can-23-2260.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Author Correction: Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson N, Mukherji A, Lo U, Xu L, Gonzalez J, Metang L, Ye J, Tirado C, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend D, Strand D, Hsieh J, Li B, Raj G, Wang T, Mu P. Author Correction: Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Nature Cancer 2022, 3: 1271-1271. PMID: 36241729, PMCID: PMC9586863, DOI: 10.1038/s43018-022-00458-y.Commentaries, Editorials and LettersCitationsAltmetric
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New Haven, CT 06511
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