Siyuan Cheng
Associate Research ScientistAbout
Research
Publications
2026
Game of clones: decipher lineage plasticity in hormone-driven cancers
Leonita A, Cheng S, Warrick J, Kim I, Deng S, Mu P. Game of clones: decipher lineage plasticity in hormone-driven cancers. Cellular And Molecular Life Sciences 2026, 83: 236. PMID: 42014520, PMCID: PMC13237331, DOI: 10.1007/s00018-026-06171-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers
Jiang Y, Cheng S, Zhang C, Jin X, Li L, Shin H, Alrefai A, Luo A, Xu Y, Kim I, Mu P. HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers. Cancer Letters 2026, 648: 218465. PMID: 41912135, DOI: 10.1016/j.canlet.2026.218465.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThis study investigates how HOX gene expression patterns identify therapy-resistant cancer subtypes and demonstrates RUNX1T1-HDAC3 inhibition as a potential treatment strategy for aggressive cancers.
2025
Regulation of INSM1 Gene Expression and Neuroendocrine Differentiation in High-Risk Neuroblastoma
Chen C, Cheng S, Yu X, Lee Y, Lan M. Regulation of INSM1 Gene Expression and Neuroendocrine Differentiation in High-Risk Neuroblastoma. Biology 2025, 15: 22. PMID: 41514864, PMCID: PMC12784908, DOI: 10.3390/biology15010022.Peer-Reviewed Original ResearchPROX1 is an early driver of lineage plasticity in prostate cancer
Duan Z, Shi M, Kumaraswamy A, Lin D, Khokhani D, Wang Y, Zhang C, Flores D, Rodansky E, Swaim O, Storck W, Beck H, Patel R, Sayar E, Hanratty B, Xue H, Dong X, Maylin Z, Wan R, Quigley D, Sjöström M, Hu Y, Zhao F, Xia Z, Cheng S, Yu X, Feng F, Zhang L, Aggarwal R, Small E, Ravikumar V, Rao A, Bedi K, Lee J, Morrissey C, Coleman I, Nelson P, Corey E, Udager A, Rebernick R, Cieslik M, Chinnaiyan A, Yates J, Haffner M, Wang Y, Alumkal J. PROX1 is an early driver of lineage plasticity in prostate cancer. Journal Of Clinical Investigation 2025, 135: e187490. PMID: 40454483, PMCID: PMC12126232, DOI: 10.1172/jci187490.Peer-Reviewed Original ResearchNotch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer.
Jiang Y, Cheng S, Li L, Fraidenburg M, Kim IY, Deng S, Mu P. Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer. BioRxiv 2025 PMID: 40501767, DOI: 10.1101/2025.05.26.656166.Peer-Reviewed Original ResearchPan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity.
Jiang Y, Cheng S, Kim IY, Deng S, Mu P. Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity. BioRxiv 2025 PMID: 40488132, DOI: 10.1101/2025.04.18.649575.Peer-Reviewed Original ResearchAndrogen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells.
Li L, Cheng S, Xu Y, Deng S, Mu P, Yu X. Androgen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells. BioRxiv 2025 PMID: 40196510, DOI: 10.1101/2025.03.26.645495.Peer-Reviewed Original ResearchSystematic multi-omics investigation of androgen receptor driven gene expression and epigenetics changes in prostate cancer
Li L, Cho K, Yu X, Cheng S. Systematic multi-omics investigation of androgen receptor driven gene expression and epigenetics changes in prostate cancer. Computers In Biology And Medicine 2025, 189: 110000. PMID: 40056843, DOI: 10.1016/j.compbiomed.2025.110000.Peer-Reviewed Original ResearchStathmin 1 expression in neuroendocrine and proliferating prostate cancer
Shi Y, Yeh Y, Cheng S, Gu X, Yang S, Li L, Khater N, Kasper S, Yu X. Stathmin 1 expression in neuroendocrine and proliferating prostate cancer. Discover Oncology 2025, 16: 19. PMID: 39776361, PMCID: PMC11711591, DOI: 10.1007/s12672-025-01754-6.Peer-Reviewed Original Research
2024
Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response
Rajasekaran S, Cheng S, Gajendran N, Shekoohi S, Chesnokova L, Yu X, Witt S. Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response. Scientific Reports 2024, 14: 27140. PMID: 39511366, PMCID: PMC11544018, DOI: 10.1038/s41598-024-78777-6.Peer-Reviewed Original Research