Taylor Intihar, MS
Research Assistant 1, HSSCards
About
Research
Publications
2026
1013 MICU Patient Characteristics Influence Variation in Light During the Day and Night Periods
Intihar T, Rao O, Crase P, Wasden K, Cabral V, Doyle M, Knauert M. 1013 MICU Patient Characteristics Influence Variation in Light During the Day and Night Periods. Sleep 2026, 49: a451-a451. DOI: 10.1093/sleep/zsag091.1012.Peer-Reviewed Original ResearchIntensive care unitPatient factorsMedical ICUBetween-individual factorsIntraclass correlation coefficientAssociated with adverse outcomesIntensive care unit admissionMedical intensive care unitSeason of admissionIndividual patient factorsObservational cohort studyMechanical ventilation statusCohort studyPatient ageSOFA scorePatient demographicsClinical dataAdverse outcomesICU admissionCare unitPatientsStudy periodVentilation statusCircadian disruptionCorrelation coefficientC22-07 Factors Influencing Medical Intensive Care Unit (MICU) Accessibility: MICU Visitor Perceptions
Sun J, Intihar T, Knauert M. C22-07 Factors Influencing Medical Intensive Care Unit (MICU) Accessibility: MICU Visitor Perceptions. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.3261. DOI: 10.1093/ajrccm/aamag162.3261.Peer-Reviewed Original ResearchImpact of transportation accessOut-of-townHotel resourcesIntensive care unitTime-of-day preferencePrivate vehiclesVisitor perceptionsTransport accessibilityVisitor experienceCommuting timeMedical ICUParking areaLodging costsVisitorsIntensive care unit visitsTransporter availabilityManagement systemMedical ICU admissionOpen-ended commentsMedical intensive care unitTertiary academic hospitalPrimary contactLogistical factorsRespondentsContacts of patients
2024
Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-Hospital DeathCritically Ill AdultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome
2023
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, Brown T, Thayer M, Kumar K, Gomez-Pastor R. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease. Cell Reports 2023, 42: 112198. PMID: 36867535, PMCID: PMC10128052, DOI: 10.1016/j.celrep.2023.112198.Peer-Reviewed Original ResearchConceptsMajor transcription factorTumor suppressor p53Huntington's diseaseHtt aggregationTranscription factorsE3 ligase MDM2Protein degradationSuppressor p53Reciprocal regulationMutant HttP53 stabilizationMolecular differencesCell proliferationHSF1Neurodegenerative diseasesP53Most cancersNeurodegenerationP53 deletionTranscriptionDegradationDeletionAbundanceHTT
2021
Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
Zarate N, Intihar T, Yu D, Sawyer J, Tsai W, Syed M, Carlson L, Gomez-Pastor R. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. International Journal Of Molecular Sciences 2021, 22: 13113. PMID: 34884918, PMCID: PMC8657899, DOI: 10.3390/ijms222313113.Peer-Reviewed Original ResearchConceptsHeat shock transcription factor 1PSD-95 levelsPSD-95 expressionPSD-95Huntington's diseaseShock transcription factor 1Synaptic protein levelsFactor 1Heat shock factor 1Direct regulatory relationshipIonotropic glutamate receptorsAge-dependent mannerShock factor 1Protein homeostasisWT miceAcute reductionSynaptic dysfunctionGene regulationTranscription factor 1Synaptic densityProtein essentialSynaptic punctaGlutamate receptorsBehavioral deficitsExcitatory synapses
2019
Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors
Intihar TA, Martinez EA, Gomez-Pastor R. Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors. Frontiers In Cellular Neuroscience 2019, 13: 103. PMID: 30941017, PMCID: PMC6433789, DOI: 10.3389/fncel.2019.00103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMutant HttTranscription factorsMitochondrial dysfunctionPGC-1αMitochondrial functionCo-activator PGC-1αTranscription factor HSF1Main transcription factorHuntington's diseaseProtein homeostasisHSF1Medium spiny neuronsP53 levelsUnifying mechanismHuntingtin geneNeurodegenerative diseasesP53ProteinPotential roleStriatal medium spiny neuronsCAG repeatsThird mechanismMisfoldHD progressionGenes