Isabella Lawrence
Postdoctoral AssociateCards
About
Research
Publications
2026
Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus
Lawrence I, Sutton E, Bhaskar S, Baserga S. Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus. Molecular Cell 2026, 86: 469-490. PMID: 41610859, PMCID: PMC12866967, DOI: 10.1016/j.molcel.2026.01.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsribosome biogenesismammalian target of rapamycin complex 1extracellular signal-regulated kinasetarget of rapamycin complex 1casein kinase IIKinase Signaling Pathwayrapamycin complex 1signal-regulated kinasemammalian targetphosphorylation eventsregulatory networkshuman ribosomecellular processesprotein phosphorylationmitotic machineryribosomecell cyclebiogenesiscellular growthsignaling pathwayhuman cellscytoplasmic organellesnucleoluscytoplasmprotein
2023
The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis
Eastham M, Pelava A, Wells G, Lee J, Lawrence I, Stewart J, Deichner M, Hertle R, Watkins N, Schneider C. The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis. Nucleic Acids Research 2023, 51: 9397-9414. PMID: 37526268, PMCID: PMC10516649, DOI: 10.1093/nar/gkad637.Peer-Reviewed Original ResearchConceptsribosomal RNAribosomal subunitribosomal subunit biogenesissmall ribosomal subunitactivation of p53induction of p53subunit biogenesisrRNA processingribosome biogenesisassembly intermediatesp53 activationp53 inductionLSUSSUcellular energygenetic diseaseshuman cellsp53production pathwayssubunitbiogenesisRNP
2021
Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations
Hochberg I, Demain L, Richer J, Thompson K, Urquhart J, Rea A, Pagarkar W, Rodríguez-Palmero A, Schlüter A, Verdura E, Pujol A, Quijada-Fraile P, Amberger A, Deutschmann A, Demetz S, Gillespie M, Belyantseva I, McMillan H, Barzik M, Beaman G, Motha R, Ng K, O’Sullivan J, Williams S, Bhaskar S, Lawrence I, Jenkinson E, Zambonin J, Blumenfeld Z, Yalonetsky S, Oerum S, Rossmanith W, Consortium G, Yue W, Zschocke J, Munro K, Battersby B, Friedman T, Taylor R, O’Keefe R, Newman W. Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations. American Journal Of Human Genetics 2021, 108: 2195-2204. PMID: 34715011, PMCID: PMC8595931, DOI: 10.1016/j.ajhg.2021.10.002.Peer-Reviewed Original ResearchConceptsbi-allelic variantssteady state levelsend processingpathogenic variantsmitochondrial-encoded proteinsDisease-Associated Variantsdisease-causing variantsmitochondrial transcriptsprecursor tRNAsRNase PtRNA processingRNA maturationRNA processingP proteinprotein subunitsmitochondrial dysfunction
Academic Achievements & Community Involvement
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Oteng-Agyei Kankam
Undergraduate Student2024 - Present