Edward Doherty, PhD
Associate Research Scientist (Rheumatology, Allergy & Immunology)DownloadHi-Res Photo
Cards
Appointments
Rheumatology
Primary
About
Copy Link
Titles
Associate Research Scientist (Rheumatology, Allergy & Immunology)
Biography
Dr. Edward Doherty studies the immune system and the dysregulation of the immune response that leads to autoimmunity. He focuses on the role of MIF receptor expressing T cells he identified in health and disease.
Last Updated on January 08, 2026.
Appointments
Rheumatology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- State University of New York Upstate, Immunology
- BS
- University of New England, Biology
Research
Copy Link
Overview
MIF is the first cytokine activity to be described and is found at high concentrations at sites of inflammation, including RA joints. I am focused on elucidating the role of the novel MIF receptor (CD74) expressing T cells I have identified in mouse models of RA. I am also building on this work to identify the role of CD74 expressing T cells in health and other diseases.
With the COVID pandemic came the widespread use of mRNA vaccines. I am a part of a collaboration to understand the larger immune response, beyond B cells and antibody production, to vaccinations with either an mRNA or a self-amplifying RNA vaccine.
ORCID
0009-0006-0642-8237
Research at a Glance
Publications Timeline
A big-picture view of Edward Doherty's research output by year.
Yale Co-Authors
Frequent collaborators of Edward Doherty's published research.
8Publications
1,038Citations
Joshua Bilsborrow, MD, MHS
Publications
Featured Publications
Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus
Doherty E, Oaks Z, Perl A. Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus. Antioxidants & Redox Signaling 2014, 21: 56-65. PMID: 24673154, PMCID: PMC4048573, DOI: 10.1089/ars.2013.5702.Peer-Reviewed Original ResearchCitationsAltmetric
2019
Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus
Bilsborrow JB, Doherty E, Tilstam PV, Bucala R. Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus. Expert Opinion On Therapeutic Targets 2019, 23: 733-744. PMID: 31414920, PMCID: PMC6800059, DOI: 10.1080/14728222.2019.1656718.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2017
Measurement of Mitochondrial Mass by Flow Cytometry during Oxidative Stress.
Doherty E, Perl A. Measurement of Mitochondrial Mass by Flow Cytometry during Oxidative Stress. Reactive Oxygen Species 2017, 4: 275-283. PMID: 29806036, PMCID: PMC5964986, DOI: 10.20455/ros.2017.839.Peer-Reviewed Original ResearchCitationsAltmetric
2012
N‐acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double‐blind, placebo‐controlled trial
Lai Z, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, Miklossy G, Jimah J, Doherty E, Tily H, Francis L, Garcia R, Dawood M, Yu J, Ramos I, Coman I, Faraone SV, Phillips PE, Perl A. N‐acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism 2012, 64: 2937-2946. PMID: 22549432, PMCID: PMC3411859, DOI: 10.1002/art.34502.Peer-Reviewed Original ResearchCitationsAltmetricAssessment of Mitochondrial Dysfunction in Lymphocytes of Patients with Systemic Lupus Erythematosus
Perl A, Hanczko R, Doherty E. Assessment of Mitochondrial Dysfunction in Lymphocytes of Patients with Systemic Lupus Erythematosus. Methods In Molecular Biology 2012, 900: 61-89. PMID: 22933065, DOI: 10.1007/978-1-60761-720-4_4.ChaptersCitationsAltmetricMeSH KeywordsAdenosine DiphosphateAdenosine TriphosphateCaspasesCell SurvivalCells, CulturedChromatography, High Pressure LiquidElectron TransportEnzyme AssaysFlow CytometryGlutathioneHumansHydrogen-Ion ConcentrationIntracellular SpaceLupus Erythematosus, SystemicLymphocyte ActivationMembrane Potential, MitochondrialMitochondriaMolecular BiologyReactive Oxygen SpeciesT-Lymphocytes
2009
T-cell and B-cell signaling biomarkers and treatment targets in lupus
Perl A, Fernandez DR, Telarico T, Doherty E, Francis L, Phillips PE. T-cell and B-cell signaling biomarkers and treatment targets in lupus. Current Opinion In Rheumatology 2009, 21: 454-464. PMID: 19550330, PMCID: PMC4047522, DOI: 10.1097/bor.0b013e32832e977c.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsPrevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine
Hanczko R, Fernandez DR, Doherty E, Qian Y, Vas G, Niland B, Telarico T, Garba A, Banerjee S, Middleton FA, Barrett D, Barcza M, Banki K, Landas SK, Perl A. Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. Journal Of Clinical Investigation 2009, 119: 1546-1557. PMID: 19436114, PMCID: PMC2689120, DOI: 10.1172/jci35722.Peer-Reviewed Original ResearchCitations
2008
Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE
Perl A, Nagy G, Koncz A, Gergely P, Fernandez D, Doherty E, Telarico T, Bonilla E, Phillips PE. Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE. Autoimmunity 2008, 41: 287-297. PMID: 18432409, PMCID: PMC5294745, DOI: 10.1080/08916930802024764.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
Academic Achievements & Community Involvement
Copy Link
Activities
activity Faculty Advisory Council
08/01/2025 - PresentCommitteesCommittee Memberactivity Partners in Collaborative Excellence
05/01/2025 - PresentCommitteesMember
News
Copy Link
Get In Touch
Copy Link