Benjamin Machta, PhD
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Machta Group
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Associate Professor Tenure
Biography
Ben Machta is an Associate Professor of Physics and member of the Systems Biology Institute at Yale University. Ben received an undergraduate degree in Physics from Brown University and a PhD from Cornell University where he used information geometry to study the emergence of simple models, and began a long-standing interest in membrane criticality. He completed a postdoc at Princeton as a Lewis-Sigler Theory fellow before moving to Yale in 2018.
Ben’s research focuses on understanding how biological systems operate using approaches from theoretical physics. His group uses statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class. They also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget.
Departments & Organizations
- Center for Neuroethology & Physiological Plasticity
- Computational Biology and Biomedical Informatics
- Swartz Program in Theoretical Neurobiology
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- PhD
- Cornell University, Physics (2013)
Research
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Overview
Our research focuses on understanding how biological systems operate using approaches from theoretical physics. We use statistical physics to understand the structure and function of biological membranes, which experiments have shown operate close to a demixing critical point in the Ising universality class. They also use tools from information theory to place physical bounds on the ability of organisms to function that arise from their limited ability to measure their environment and from their limited energy budget.
Medical Research Interests
ORCID
0000-0001-9065-614XMachta Group
The group’s research focuses on understanding how biological systems operate using approaches from theoretical physics.
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Research at a Glance
Yale Co-Authors
Research Interests
Thierry Emonet
Ane Landajuela Larma
Carolina Gomis Perez, PhD
Gunter Wagner, PhD
Physics
Publications
2026
Lattice Ultrasensitivity Amplifies Signals in E. coli without Finely-Tuned Allosteric Interactions
Sherry D, Graf I, Bryant S, Emonet T, Machta B. Lattice Ultrasensitivity Amplifies Signals in E. coli without Finely-Tuned Allosteric Interactions. PRX Life 2026, 4: 023027. DOI: 10.1103/7dgz-l5fd.Peer-Reviewed Original ResearchAltmetricE. coli chemosensing accuracy is not limited by stochastic molecule arrivals
Mattingly H, Kamino K, Ong J, Kottou R, Emonet T, Machta B. E. coli chemosensing accuracy is not limited by stochastic molecule arrivals. Nature Physics 2026, 22: 123-130. PMID: 41550616, PMCID: PMC12811142, DOI: 10.1038/s41567-025-03111-4.Peer-Reviewed Original ResearchCitationsAltmetricThe membrane transition strongly enhances biopolymer condensation through prewetting
Bagheri Y, Rouches M, Machta B, Veatch S. The membrane transition strongly enhances biopolymer condensation through prewetting. Nature Chemical Biology 2026, 1-11. PMID: 41482580, PMCID: PMC13082473, DOI: 10.1038/s41589-025-02082-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsendoplasmic reticulumER-PM contact sitesplasma membraneliquid-ordered/liquid-disordered phase coexistencemembrane lipidsassembly of soluble proteinsmembrane compositionsensitive to lipid compositionprewetting transitionbiopolymer condensationphase coexistencecontact sitessoluble proteinsmembrane adhesionprewettingoptogenetic toolslipid compositiondilute phasemembrane transitionmembranemodel membranescellstransitionlipidreticulum
2025
Pseudo-perplexity in one fell swoop for protein fitness estimation
Kantroo P, Wagner G, Machta B. Pseudo-perplexity in one fell swoop for protein fitness estimation. PRX Life 2025, 3: 033014. PMID: 39040648, PMCID: PMC11261985, DOI: 10.1103/zhx7-hcmm.Peer-Reviewed Original ResearchCitationsAltmetricConceptslanguage modelcontext-sensitive representationsobject learningdimensional spacefitness estimatesdownstream modelsprobability vectorcomputational efficiencyreconstructed ancestral sequencestraining objectivesfunctional sequence spaceprotein language modelsamino acid residuesancestral sequencesacid residuesProtein-DNA co-condensation is prewetting to a collapsed polymer
Rouches M, Machta B. Protein-DNA co-condensation is prewetting to a collapsed polymer. Biophysical Journal 2025, 124: 2280-2290. PMID: 40474478, PMCID: PMC12414680, DOI: 10.1016/j.bpj.2025.05.031.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsnuclear proteinsthree-dimensional organizationlattice Monte-Carlo simulationsmean-field theorythree-dimensional organization of chromatininteraction of transcription factorsorganization of chromatinregions of chromatinabsence of DNAsequencing of DNAprewetting transitionpolymer collapsecoexisting liquid phasesnovel phasestranscription factorsthermodynamic forcesconfiguration transitiongene expressionchromatinMonte-Carlo simulationsliquid dropletsprewettingDNAproteinprotein mixturesBPS2025 - Protein prewetting as a probe of plasma membrane structure and function
Bagheri Y, Rouches M, Machta B, Veatch S. BPS2025 - Protein prewetting as a probe of plasma membrane structure and function. Biophysical Journal 2025, 124: 337a. DOI: 10.1016/j.bpj.2024.11.1851.Peer-Reviewed Original ResearchHair Cells in the Cochlea Must Tune Resonant Modes to the Edge of Instability without Destabilizing Collective Modes
Momi A, Abbott M, Rubinfien J, Machta B, Graf I. Hair Cells in the Cochlea Must Tune Resonant Modes to the Edge of Instability without Destabilizing Collective Modes. PRX Life 2025, 3: 013001. PMID: 40657493, PMCID: PMC12252909, DOI: 10.1103/prxlife.3.013001.Peer-Reviewed Original ResearchCitationsAltmetric
2024
A bifurcation integrates information from many noisy ion channels and allows for millikelvin thermal sensitivity in the snake pit organ
Graf I, Machta B. A bifurcation integrates information from many noisy ion channels and allows for millikelvin thermal sensitivity in the snake pit organ. Biophysical Journal 2024, 123: 325a-326a. DOI: 10.1016/j.bpj.2023.11.1991.Peer-Reviewed Original ResearchCitationsPrewetting and surface phase transitions on polymer scaffolds and critical membranes
Rouches M, Veatch S, Machta B. Prewetting and surface phase transitions on polymer scaffolds and critical membranes. Biophysical Journal 2024, 123: 494a. DOI: 10.1016/j.bpj.2023.11.2992.Peer-Reviewed Original ResearchA bifurcation integrates information from many noisy ion channels and allows for milli-Kelvin thermal sensitivity in the snake pit organ
Graf I, Machta B. A bifurcation integrates information from many noisy ion channels and allows for milli-Kelvin thermal sensitivity in the snake pit organ. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2308215121. PMID: 38294944, PMCID: PMC10861916, DOI: 10.1073/pnas.2308215121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
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