As a physician-scientist, Dr. Seli's primary focus is to understand and treat infertility. His laboratory characterized the mechanisms regulating translational activation of gene expression in the oocyte. Dr. Seli and his colleagues also made seminal contributions to our understanding of oocyte and embryo competence in IVF and the potential role of non-invasive diagnostic technologies in this context. Dr. Seli is the recipient of many National Institutes of Health (NIH) and pharmaceutical industry-sponsored research grants. He has trained more than 50 pre- and post-doctoral fellows, published more than 100 scientific articles, and received numerous research awards, including the Ira and Ester Rosenwaks New Investigator Award from the American Society for Reproductive Medicine (ASRM), and the President’s Achievement Award from the Society for Reproductive Investigation (SRI). Dr. Seli’s current research focuses on determinants of oocyte and embryo health, and mechanisms of ovarian ageing.
Extensive Research Description
For detailed information regarding research in Seli laboratory please visit our website https://medicine.yale.edu/obgyn/drs/research/infertility/seli.aspx
- Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proc Natl Acad Sci USA 102:367-72, 2005
- Vasudevan S, Seli E, Steitz JA. Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. Genes Dev 20:138-46, 2006.
- Seli E, Sakkas D, Scott R, Kwok JS, Rosendahl S, Burns DH. Non-Invasive metabolomic profiling of human embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril 88:1350-7, 2007.
- Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (ePAB) RNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Mol Hum Reprod 14:393-8, 2008.
- Seli E, Botros L, Sakkas D, Burns DH. Non-invasive metabolomic profiling of embryo culture media using proton NMR correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril 90:2183-9, 2008
- Guzeloglu-Kayisli O, Pauli SA, Demir H, Lalioti MD, Sakkas D, Seli E. Identification and characterization of human embryonic poly(A) binding protein (ePAB). Mol Hum Reprod 14:581-8, 2008.
- Botros L, Sakkas D, Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Mol Hum Reprod 14:679-90, 2008.
- Seli E, Vergouw CG, Kato O, Botros L, Roos P, Morita H, Lambalk CB, Yamashita N, Sakkas D. Metabolomic profiling as an adjunct to morphology for non-invasive embryo assessment in women undergoing single embryo transfer. Fertil Steril, 94:535-42, 2010.
- Seli E, Robert C, and Sirard M-A. OMICS in assisted reproduction: possibilities and pitfalls. Mol Hum Reprod, 16:513-30, 2010.
- Karipcin S, Altun T, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium. Reprod Sci, 18:145-55, 2011.
- Friend JK, Brook ML, Bezirci FB, Sheets MD, Gray NR, Seli E. Dynamic phosphorylation of embryonic poly(A)-binding protein (ePAB) is required for Xenopus oocyte maturation. Biochem J, 445:93-100, 2012.
- Guzeloglu-Kayisli O, Lalioti MD, Sasson I, Aydiner F, Sakkas D, Seli E. Embryonic poly(A) binding protein (EPAB) is required for oocyte maturation and female fertility in mouse. Biochem J, 446:47-58, 2012.