2005
Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain
Wood J, Waxman S. Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain. 2005, 339-355. DOI: 10.1016/b978-012738903-5/50021-7.Peer-Reviewed Original ResearchNeuropathic painPeripheral nervous system degenerationGene regulation studiesMolecular targetsAnimal modelsInteresting drug targetGene expressionRegulatory moleculesNew molecular targetsMolecular mechanismsEffective drug developmentNervous system degenerationTransgenic animalsUseful animal modelRegulation studiesDrug targetsGene ablationEfficacy of drugsConsequence of diseaseHerpes zosterImmunodeficiency syndromeRecent insightsPeripheral nervesSystem degenerationPain
2002
Sodium channels and the molecular basis for pain
Black J, Cummins T, Dib-Hajj S, Waxman S. Sodium channels and the molecular basis for pain. Progress In Inflammation Research 2002, 23-50. DOI: 10.1007/978-3-0348-8129-6_2.ChaptersPrimary sensory neuronsSensory neuronsAction potentialsSpontaneous action potentialsHigh-frequency activityInflammatory painTrigeminal neuronsNociceptive responsesAscending pathwaysPeripheral nervesTissue injuryNoxious stimuliPeripheral targetsPainNeuronsSodium channelsTemperature sensationBrainHigh thresholdNerveMolecular basisInjuryAxonsDRG
2000
Voltage-gated sodium channels and the molecular pathogenesis of pain: a review.
Waxman SG, Cummins TR, Dib-Hajj SD, Black JA. Voltage-gated sodium channels and the molecular pathogenesis of pain: a review. The Journal Of Rehabilitation Research And Development 2000, 37: 517-28. PMID: 11322150.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsDRG neuronsNervous systemSodium channelsDistinct voltage-gated sodium channelsAction potentialsSpinal sensory neuronsSodium channel expressionSpontaneous action potentialsDifferent sodium channelsSpecific sodium channelsUnderstanding of painHigh-frequency activityInflammatory painPain pathwaysChronic painNociceptive signalsPeripheral nervesSensory neuronsNew therapiesPainChannel expressionMolecular pathogenesisPharmacologic manipulationNeuron cell membrane
1998
Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult rats
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarizationCompound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis
Stys P, Ransom B, Waxman S. Compound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis. Brain Research 1991, 546: 18-32. PMID: 1855148, DOI: 10.1016/0006-8993(91)91154-s.Peer-Reviewed Original Research
1987
Chapter 8 Ionic channel organization of normal and regenerating mammalian axons
Kocsis J, Waxman S. Chapter 8 Ionic channel organization of normal and regenerating mammalian axons. Progress In Brain Research 1987, 71: 89-101. PMID: 2438722, DOI: 10.1016/s0079-6123(08)61816-6.Peer-Reviewed Original ResearchConceptsNerve fibersPeripheral nervesRegenerated nerve fibersCell remodellingNormal developmentMammalian nerve fibresSchwann cellsElectrophysiological characteristicsFine caliberMyelinated axonsImmature axonsAxonal growthMammalian axonsNerveNormal maturationRemodelling occursAxonsCell arrestRemodellingTime courseMyelinIonic channelsLong termMaturationTime of maturation
1985
Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike
1977
Evidence for inorganic phosphate binding at nodes of Ranvier in peripheral nerves
Quick D, Waxman S. Evidence for inorganic phosphate binding at nodes of Ranvier in peripheral nerves. Journal Of The Neurological Sciences 1977, 33: 207-211. PMID: 903783, DOI: 10.1016/0022-510x(77)90194-0.Peer-Reviewed Original Research
1974
Ongoing activity in peripheral nerve: Injury discharge
Wall P, Waxman S, Basbaum A. Ongoing activity in peripheral nerve: Injury discharge. Experimental Neurology 1974, 45: 576-589. PMID: 4435078, DOI: 10.1016/0014-4886(74)90163-0.Peer-Reviewed Original Research
1972
Relative Conduction Velocities of Small Myelinated and Non-myelinated Fibres in the Central Nervous System
WAXMAN S, BENNETT M. Relative Conduction Velocities of Small Myelinated and Non-myelinated Fibres in the Central Nervous System. Nature 1972, 238: 217-219. PMID: 4506206, DOI: 10.1038/newbio238217a0.Peer-Reviewed Original Research
1970
Closely Spaced Nodes of Ranvier in the Teleost Brain
WAXMAN S. Closely Spaced Nodes of Ranvier in the Teleost Brain. Nature 1970, 227: 283-284. PMID: 5428197, DOI: 10.1038/227283a0.Peer-Reviewed Original Research
1968
Micropinocytotic invaginations in the axolemma of peripheral nerves
Waxman S. Micropinocytotic invaginations in the axolemma of peripheral nerves. Cell And Tissue Research 1968, 86: 571-573. PMID: 5707296, DOI: 10.1007/bf00324867.Peer-Reviewed Original Research