2016
Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes
Lipska KJ, Krumholz H, Soones T, Lee SJ. Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes. JAMA 2016, 315: 1034-1045. PMID: 26954412, PMCID: PMC4823136, DOI: 10.1001/jama.2016.0299.BooksConceptsRandomized clinical trialsIntensive glycemic controlGlycemic controlClinical trialsOlder adultsMicrovascular outcomesTreatment burdenPatient preferencesMost RCTsLarge randomized clinical trialsType 2 diabetes mellitusMajor macrovascular eventsStandard glycemic controlOptimal glycemic controlLower treatment burdenSurrogate end pointsHigh-quality evidenceType 2 diabetesLikelihood of benefitMajority of adultsGlycemic treatmentMacrovascular eventsDiabetes mellitusPatient factorsAging Patient
2011
Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure
Wong CY, Chaudhry SI, Desai MM, Krumholz HM. Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure. The American Journal Of Medicine 2011, 124: 136-143. PMID: 21295193, PMCID: PMC3237399, DOI: 10.1016/j.amjmed.2010.08.017.Peer-Reviewed Original ResearchConceptsProportion of patientsHeart failureSelf-reported heart failureHeart failure populationComorbid chronic conditionsNumber of comorbiditiesNutrition Examination SurveyCare of patientsPrevalence of disabilityPhenotype of patientsComplexity of patientsMedication useRecent patientsFunctional disabilityExamination SurveyFailure populationPhysical functionPrescription medicationsPatient preferencesChronic conditionsNational HealthPatient's abilityComorbiditiesPatientsOlder individuals
2005
Systolic Hypertension in Older Persons: Complexities in Clinical Decision Making
Foody JM, Chaudhry SI, Krumholz HM. Systolic Hypertension in Older Persons: Complexities in Clinical Decision Making. The American Journal Of Geriatric Cardiology 2005, 14: 325-330. PMID: 16276131, DOI: 10.1111/j.1076-7460.2005.04537.x.BooksConceptsOlder personsSystolic hypertensionHypertension treatment decisionsJoint National CommitteeBlood pressure controlHigh blood pressureEvidence-based careHealth care providersFinal management planHealth care decisionsOlder patientsBlood pressurePatient preferencesSeventh ReportTreatment preferencesTreatment decisionsIndividual patientsIndividualized riskTreatment goalsCare providersClinical decisionPressure controlMost health care decisionsCare decisionsPatients
2004
Differences, disparities, and biases: clarifying racial variations in health care use.
Rathore SS, Krumholz HM. Differences, disparities, and biases: clarifying racial variations in health care use. Annals Of Internal Medicine 2004, 141: 635-8. PMID: 15492343, DOI: 10.7326/0003-4819-141-8-200410190-00011.Peer-Reviewed Original ResearchConceptsHealth care useCare useRacial variationRacial differencesHealth care system factorsAdverse consequencesClinical factorsClinical contraindicationsTreatment eligibilityPatient preferencesObservational studyEvidence of differencesMedical literatureRacial disparitiesHealth careInitial reportSystem factorsDifferent causesTreatmentReports of variationReportDisparitiesContraindicationsDifferencesCareSystolic Hypertension in Older Persons
Chaudhry SI, Krumholz HM, Foody JM. Systolic Hypertension in Older Persons. JAMA 2004, 292: 1074-1080. PMID: 15339901, DOI: 10.1001/jama.292.9.1074.BooksConceptsSystolic blood pressureSystolic hypertensionBlood pressureOlder personsOlder patientsClinical trialsBaseline systolic blood pressureTolerance of therapyJoint National CommitteeFirst-line therapyDiastolic blood pressureHigh blood pressureCalcium channel blockersRandomized clinical trialsTreatment of patientsEnglish-language literatureLarge-scale trialsSearch terms hypertensionAntihypertensive therapyCardiovascular riskThiazide diureticsDATA EXTRACTIONPatient preferencesSeventh ReportTerm hypertension
2003
Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint
Foody JM, Krumholz HM. Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint. The American Journal Of Geriatric Cardiology 2003, 12: 357-360. PMID: 14610384, DOI: 10.1111/j.1076-7460.2003.02912.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePrimary preventionArtery diseaseOvert coronary artery diseaseRisk of myositisCardiovascular disease eventsRole of statinsUse of statinsAge 65 yearsBalance of risksCardiovascular eventsStatin therapyPatient preferencesCholesterol levelsCardiovascular diseaseOctogenariansClinical uncertaintyDisease eventsCurrent evidenceStatinsAge groupsDiseasePreventionRiskMyositis
1998
Resuscitation Preferences Among Patients With Severe Congestive Heart Failure
Krumholz H, Phillips R, Hamel M, Teno J, Bellamy P, Broste S, Califf R, Vidaillet H, Davis R, Muhlbaier L, Connors A, Lynn J, Goldman L. Resuscitation Preferences Among Patients With Severe Congestive Heart Failure. Circulation 1998, 98: 648-655. PMID: 9715857, DOI: 10.1161/01.cir.98.7.648.Peer-Reviewed Original ResearchConceptsSevere congestive heart failureCongestive heart failureResuscitation preferencesHeart failurePhysicians' perceptionsPatient preferencesMonths of dischargePoor functional statusQuarter of patientsSevere heart failureDiscussion of preferencesWorse prognosisFunctional statusPatientsOlder agePhysiciansSubstantial proportionSignificant correlatesResuscitationMonthsHigh agreementFailureHigher incomeExacerbationPrognosis