2023
Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis
Bender U, Norris C, Dreyer R, Krumholz H, Raparelli V, Pilote L. Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis. Journal Of The American Heart Association 2023, 12: e028553. PMID: 37489737, PMCID: PMC10492965, DOI: 10.1161/jaha.122.028553.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionMyocardial infarctionGender-related factorsLonger LOSSegment elevation myocardial infarction diagnosisConclusions Older ageObservational cohort studyAdverse clinical outcomesAdjusted multivariable modelAcute myocardial infarctionLength of stayImpact of sexHealth care expendituresGENESIS-PRAXYHospital lengthNon–STCause mortalityCohort studyIndependent predictorsMyocardial infarction diagnosisClinical outcomesShorter LOSMedical historyMultivariable modelUnivariate associations
2021
Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction
Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, Dodson JA, Forman DE, Krumholz H, Chaudhry SI. Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction. Journal Of Cardiopulmonary Rehabilitation And Prevention 2021, 42: 109-114. PMID: 34799530, PMCID: PMC8881286, DOI: 10.1097/hcr.0000000000000627.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUtilization of CRCardiac rehabilitationCR participationOlder adultsMyocardial infarctionSensory impairmentMultivariable-adjusted logistic regression modelsNationwide prospective cohort studyOlder AMI patientsCardiac rehabilitation participationProspective cohort studyYr of educationSILVER-AMI StudyLogistic regression modelsSecondary preventionClinical factorsCohort studyPatient ageIndependent predictorsAMI patientsRehabilitation participationPsychosocial factorsCR useExtensive baseline data
2019
Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
Dodson JA, Hajduk A, Curtis J, Geda M, Krumholz HM, Song X, Tsang S, Blaum C, Miller P, Parikh CR, Chaudhry SI. Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2019, 132: e817-e826. PMID: 31170374, PMCID: PMC6891160, DOI: 10.1016/j.amjmed.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute Kidney InjuryAge FactorsAgedAged, 80 and overCohort StudiesCoronary AngiographyDatabases, FactualFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsAcute kidney injuryAcute myocardial infarctionAge-related conditionsKidney injuryBody mass indexCoronary angiographyRisk factorsMyocardial infarctionOlder patientsMean ageAcute kidney injury risk factorsAcute Myocardial Infarction StudyAcute myocardial infarction cohortOlder adultsGlobal Outcomes criteriaMyocardial Infarction StudyInjury risk factorsParticipants' mean ageSILVER-AMI StudyMultivariable adjustmentComorbid diseasesHeart failureIndependent predictorsGeriatric conditionsMass index
2012
Hospitalist utilization and hospital performance on 6 publicly reported patient outcomes
Goodrich K, Krumholz HM, Conway PH, Lindenauer P, Auerbach AD. Hospitalist utilization and hospital performance on 6 publicly reported patient outcomes. Journal Of Hospital Medicine 2012, 7: 482-488. PMID: 22689448, PMCID: PMC3531241, DOI: 10.1002/jhm.1943.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPercentage of patientsHeart failurePatient outcomesOutcome measuresPresence of hospitalistsReadmission measuresCongestive heart failureCross-sectional studyMultivariable regression modelsComparison of hospitalQuality outcome measuresReadmission ratesIndependent predictorsMyocardial infarctionInpatient careHospitalist serviceHospitalist useMedical conditionsHospital personnelHospitalist programHospitalistsHospitalExpectation of improvementOutcomes
2010
Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure
Chaudhry SI, Wang Y, Gill TM, Krumholz HM. Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 309-316. PMID: 20117435, PMCID: PMC2832791, DOI: 10.1016/j.jacc.2009.07.066.Peer-Reviewed Original ResearchConceptsLong-term mortalityGeriatric conditionsNet reclassification improvementMobility disabilityOlder patientsReclassification improvementRisk factorsMultivariable logistic regression modelHeart failure hospitalizationIndependent risk factorTraditional risk factorsMedical record dataFinal multivariable modelYears of ageLogistic regression modelsFailure hospitalizationTerm mortalityHeart failureIndependent predictorsPrognostic importanceMean ageMultivariable modelMedicare beneficiariesMortality rateSubsequent mortality
2006
Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study. International Journal Of Behavioral Medicine 2006, 13: 229-236. PMID: 17078773, DOI: 10.1207/s15327558ijbm1303_6.Peer-Reviewed Original ResearchConceptsHealth-related controlCoronary artery bypassPhysical functioningArtery bypassHospital dischargeIndependent predictorsProspective studyCaucasian manMean ageSignificant associationOne-way analysisMeasure outcomesBypassIntervention effortsMonthsWeeksX timeSignificant interactionBeneficial impactPositive changesPatients
2005
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project. JAMA Internal Medicine 2005, 165: 2237-2244. PMID: 16246989, DOI: 10.1001/archinte.165.19.2237.Peer-Reviewed Original ResearchConceptsHeart failureLower hematocrit levelsIndependent predictorsHematocrit levelsComorbid illnessesHigh riskCare ProjectMultivariable logistic regression analysisPatients 65 yearsPrincipal discharge diagnosisAcute care hospitalsLogistic regression analysisLow hematocrit valuesCause mortalityHF patientsMultiple comorbiditiesMultivariable adjustmentOlder patientsCare hospitalClinical factorsHospital readmissionComorbid conditionsDischarge diagnosisSevere anemiaAdverse outcomes
2004
Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY.
Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Wang Y, Young JB, Krumholz HM. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY. American Heart Journal 2004, 147: 331-338. PMID: 14760333, DOI: 10.1016/j.ahj.2003.08.012.Peer-Reviewed Original ResearchConceptsFluid intake/outputHeart failureIntake/outputRenal functionHigh riskCalcium channel blocker useHistory of HFAssociation of medicationLoop diuretic dosesPredictors of WRFElevated creatinine levelEnzyme inhibitor useHeart failure treatmentCase-control studyUse of CCBGreater fluid lossHigher hematocrit levelsUncontrolled hypertensionBlocker useDiuretic dosesCreatinine levelsInhibitor useAcute treatmentDiabetes mellitusIndependent predictorsSocial Support as a Predictor of Participation in Cardiac Rehabilitation After Coronary Artery Bypass Graft Surgery
Husak L, Krumholz HM, Lin ZQ, Kasl SV, Mattera JA, Roumanis SA, Vaccarino V. Social Support as a Predictor of Participation in Cardiac Rehabilitation After Coronary Artery Bypass Graft Surgery. Journal Of Cardiopulmonary Rehabilitation And Prevention 2004, 24: 19-26. PMID: 14758099, DOI: 10.1097/00008483-200401000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedConnecticutCoronary Artery BypassCoronary DiseaseFemaleFollow-Up StudiesHumansMaleMarital StatusMiddle AgedMultivariate AnalysisPredictive Value of TestsPrevalenceQuality of LifeReferral and ConsultationRisk FactorsSickness Impact ProfileSocial SupportStroke VolumeSurvival AnalysisTreatment OutcomeConceptsCoronary artery bypass graftCardiovascular disease risk factorsDisease risk factorsCardiac rehabilitationRisk factorsCoronary artery bypass graft surgeryArtery bypass graft surgerySocial supportBypass graft surgeryArtery bypass graftBetter physical functionCardiac rehabilitation participationQuality of lifeLow social supportMain predictive variableComorbidity burdenHospital complicationsGraft surgerySocial Support InventoryIndependent predictorsBypass graftPhysical functionPredictors of participationUnadjusted analysesMedical history
2003
Outcomes in heart failure patients with preserved ejection fraction Mortality, readmission, and functional decline
Smith GL, Masoudi FA, Vaccarino V, Radford MJ, Krumholz HM. Outcomes in heart failure patients with preserved ejection fraction Mortality, readmission, and functional decline. Journal Of The American College Of Cardiology 2003, 41: 1510-1518. PMID: 12742291, DOI: 10.1016/s0735-1097(03)00185-2.Peer-Reviewed Original ResearchConceptsDepressed ejection fractionRisk of readmissionEjection fractionHeart failureFunctional declineHeart failure patientsHF patientsFailure patientsHospital dischargeHospital readmissionIndependent predictorsClinical outcomesPoor prognosisFunctional statusClinical covariatesClinical trajectoriesReadmissionLower riskPatientsConsiderable burdenCombined outcomeNatural historyMortalityDeathOutcomesThe prognostic importance of anemia in patients with heart failure
Kosiborod M, Smith GL, Radford MJ, Foody JM, Krumholz HM. The prognostic importance of anemia in patients with heart failure. The American Journal Of Medicine 2003, 114: 112-119. PMID: 12586230, DOI: 10.1016/s0002-9343(02)01498-5.Peer-Reviewed Original ResearchConceptsHeart failureLow hematocritHospital readmissionPrognostic importanceHematocrit levelsMultivariate Cox proportional hazards regressionLeft ventricular ejection fractionCox proportional hazards regressionTraditional risk factorsVentricular ejection fractionPrincipal discharge diagnosisProportional hazards regressionRisk of deathElderly patientsOlder patientsClinical factorsEjection fractionIndependent predictorsDischarge diagnosisHazards regressionMedian hematocritPrognostic valueMean ageTreatable conditionRisk factors
2002
Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly
Lichtman JH, Krumholz HM, Wang Y, Radford MJ, Brass LM. Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly. Circulation 2002, 105: 1082-1087. PMID: 11877359, DOI: 10.1161/hc0902.104708.Peer-Reviewed Original ResearchConceptsMonths of dischargeRisk of strokeAcute myocardial infarctionMyocardial infarctionIschemic strokeOlder patientsStroke admission ratesPatients 75 yearsPeripheral vascular diseasePredictors of strokeRisk stratification scoresRate of admissionSimple clinical factorsPrior strokeStroke admissionsClinical factorsHospital admissionIndependent predictorsStratification scoresAtrial fibrillationBlack racePrincipal diagnosisVascular diseaseAdmission ratesMedicare patients
2001
The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project
Barron H, Harr S, Radford M, Wang Y, Krumholz H. The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project. Journal Of The American College Of Cardiology 2001, 38: 1654-1661. PMID: 11704377, DOI: 10.1016/s0735-1097(01)01613-8.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite blood cell countBlood cell countWBC countWhite blood cellsYears of ageIndependent predictorsCell countDevelopment of AMIAcute myocardial infarction mortalityHospital clinical eventsLong-term mortalityRisk-stratify patientsCoronary artery diseaseCooperative Cardiovascular Project databaseStrong independent predictorCooperative Cardiovascular ProjectMyocardial infarction mortalityImportant clinical implicationsHospital mortalityArtery diseaseHospital eventsClinical eventsHighest quintileLowest quintile
2000
Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction
Brass L, Lichtman J, Wang Y, Gurwitz J, Radford M, Krumholz H. Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction. Stroke 2000, 31: 1802-1811. PMID: 10926938, DOI: 10.1161/01.str.31.8.1802.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionThrombolytic therapyIntracranial hemorrhageMyocardial infarctionElderly patientsIntracranial Hemorrhage AssociatedRetrospective cohort studyRisk stratification scaleMain outcome measuresAcute care hospitalsTissue plasminogen activatorExcessive anticoagulationPrior strokeCohort studyOlder patientsBlood pressureHemorrhage AssociatedIndependent predictorsMedical chartsSerious complicationsMedian weightAlternate therapyBlack racePrincipal diagnosisMedicare patientsPulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertension
1999
Risk factors for heart failure in the elderly: a prospective community-based study
Chen Y, Vaccarino V, Williams C, Butler J, Berkman L, Krumholz H. Risk factors for heart failure in the elderly: a prospective community-based study. The American Journal Of Medicine 1999, 106: 605-612. PMID: 10378616, DOI: 10.1016/s0002-9343(99)00126-6.Peer-Reviewed Original ResearchConceptsTraditional cardiovascular risk factorsCardiovascular risk factorsHeart failureRisk factorsMyocardial infarctionRisk ratioCommunity-based elderly populationProportional hazards regression modelsProspective community-based studyIncident heart failureBody mass indexHazards regression modelsConfidence intervalsCommunity-based studyManagement of diabetesYears of ageConnecticut cohortChart reviewBlood pressureIndependent predictorsMass indexMale sexElderly ProgramPulse pressurePreventive strategies
1998
Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure
Krumholz H, Butler J, Miller J, Vaccarino V, Williams C, Mendes de Leon C, Seeman T, Kasl S, Berkman L. Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure. Circulation 1998, 97: 958-964. PMID: 9529263, DOI: 10.1161/01.cir.97.10.958.Peer-Reviewed Original ResearchConceptsNonfatal cardiovascular eventsClinical heart failureHeart failureElderly patientsCardiovascular eventsPrognostic importanceNonfatal cardiovascular outcomesCoronary artery diseaseEmotional supportCommunity-based studyCardiovascular outcomesArtery diseaseIndependent predictorsUnadjusted analysesFunctional statusMedical recordsClinical severityOdds ratioEpidemiologic studiesHigh riskPatientsPsychosocial supportEstablished PopulationsAdmissionDemographic factors