2022
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
Khera AV, Wang M, Chaffin M, Emdin CA, Samani NJ, Schunkert H, Watkins H, McPherson R, Erdmann J, Elosua R, Boerwinkle E, Ardissino D, Butterworth A, Di Angelantonio E, Naheed A, Danesh J, Chowdhury R, Krumholz H, Sheu W, Rich S, Rotter J, Chen Y, Gabriel S, Lander E, Saleheen D, Kathiresan S. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circulation Genomic And Precision Medicine 2022, 15: e003598. PMID: 36215124, PMCID: PMC9771961, DOI: 10.1161/circgen.121.003598.Peer-Reviewed Original ResearchConceptsMolecular subtypesCAD riskHigher systolic blood pressureCoronary artery disease patientsEndothelial nitric oxide synthase geneDamaging missense variantsRisk of CADSystolic blood pressureCoronary artery diseaseRisk of hypertensionNitric oxide synthase geneMissense variantsNitric oxide synthesisRare variantsOxide synthase geneDiscrete molecular subtypesNitric Oxide SignalingLow density lipoprotein receptor geneArtery diseaseBlood pressureEndothelial functionVascular toneDisease patientsCAD casesCholesterol concentrations
2020
Heterogeneity in Trajectories of Systolic Blood Pressure among Young Adults in Qingdao Port Cardiovascular Health Study
Lin H, Cui M, Spatz ES, Wang Y, Lu J, Li J, Li S, Huang C, Liu X, Jiang L, Krumholz HM, Xu X. Heterogeneity in Trajectories of Systolic Blood Pressure among Young Adults in Qingdao Port Cardiovascular Health Study. Global Heart 2020, 15: 20. PMID: 32489793, PMCID: PMC7218791, DOI: 10.5334/gh.764.Peer-Reviewed Original ResearchConceptsSystolic blood pressureHigher systolic blood pressureCardiovascular Health StudyBlood pressureYoung adultsHealth StudyEffective blood pressure controlBaseline systolic blood pressureInitial systolic blood pressureGreater body mass indexBlood pressure controlBody mass indexGreater waist circumferenceBaseline health characteristicsSBP trendsWaist circumferenceMass indexSBP trajectoriesAdvanced ageOrdinal logistic regressionRisk factorsCardiovascular diseaseFamily historyHealth characteristicsHigh school education
2010
The relationship between systolic blood pressure on admission and mortality in older patients with heart failure
Vidán MT, Bueno H, Wang Y, Schreiner G, Ross JS, Chen J, Krumholz HM. The relationship between systolic blood pressure on admission and mortality in older patients with heart failure. European Journal Of Heart Failure 2010, 12: 148-155. PMID: 20083624, PMCID: PMC2807767, DOI: 10.1093/eurjhf/hfp195.Peer-Reviewed Original ResearchConceptsAdmission systolic blood pressureSystolic blood pressureHeart failureBlood pressureOlder patientsNational Heart Failure ProjectHigher systolic blood pressureInitial systolic blood pressureHeart Failure ProjectMultivariable logistic regressionPrevious hypertensionSBP 90Ventricular dysfunctionClinical factorsIndependent associationOdds ratioMedicare patientsMortality ratePatientsMmHgLogistic regressionMortalityAdmissionSubgroupsInverse relationship
1999
Sex differences in the clinical care and outcomes of congestive heart failure in the elderly
Vaccarino V, Chen Y, Wang Y, Radford M, Krumholz H. Sex differences in the clinical care and outcomes of congestive heart failure in the elderly. American Heart Journal 1999, 138: 835-842. PMID: 10539813, DOI: 10.1016/s0002-8703(99)70007-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsAspirinBlood PressureCardiac CatheterizationConnecticutCoronary AngiographyDiureticsDrug Therapy, CombinationFemaleFollow-Up StudiesHeart FailureHumansMaleMyocardial RevascularizationPatient ReadmissionPlatelet Aggregation InhibitorsRetrospective StudiesSeverity of Illness IndexSex CharacteristicsStroke VolumeSurvival RateTreatment OutcomeConceptsHistory of hypertensionSystolic blood pressureHeart failureMortality rateBlood pressureHeart diseaseHigher systolic blood pressureLeft ventricular systolic functionSex differencesPrevious coronary heart diseaseSimilar hospital coursesVentricular systolic functionCongestive heart failureIschemic heart diseaseCoronary heart diseaseHospital courseElderly patientsReadmission ratesRehospitalization ratesSystolic functionMale patientsVentricular functionACE inhibitorsMultivariable analysisTreatment patterns