2020
Association Between Depressive Symptoms and Incident Cardiovascular Diseases
Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW. Association Between Depressive Symptoms and Incident Cardiovascular Diseases. JAMA 2020, 324: 2396-2405. PMID: 33320224, PMCID: PMC7739139, DOI: 10.1001/jama.2020.23068.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHazard ratioStroke eventsCardiovascular diseaseCorresponding incidence ratesDepressive symptomsHigher depression scoresCHD eventsCVD eventsCVD incidencePooled analysisIncidence rateDepression scoresNonfatal coronary heart diseasePatient Health Questionnaire-2Epidemiological Studies Depression ScaleIncident cardiovascular diseasePHQ-2 scoreAdditional risk factorsBaseline depressive symptomsSelf-reported depressive symptomsCES-D scoresEmerging Risk Factors CollaborationIndividual participant dataUK Biobank
2013
Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis
Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, Agatston A, Blumenthal RS, Nasir K. Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis. European Heart Journal 2013, 35: 2232-2241. PMID: 24366919, PMCID: PMC4150068, DOI: 10.1093/eurheartj/eht508.Peer-Reviewed Original ResearchConceptsCoronary artery calciumCoronary heart disease eventsRisk factor burdenHeart disease eventsMulti-Ethnic StudyCAC 0Artery calciumRF burdenEvent ratesDisease eventsAbsence of CACDistribution of CACTraditional risk factor burdenCHD event ratesElevated event rateHigh CAC burdenFramingham risk scoreLow HDL cholesterolLow event ratesCAC burdenCHD eventsCAC scoreHDL cholesterolLDL cholesterolCigarette smoking
1998
Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991
Mendes de Leon CF, Krumholz HM, Seeman TS, Vaccarino V, Williams CS, Kasl SV, Berkman LF. Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991. JAMA Internal Medicine 1998, 158: 2341-2348. PMID: 9827785, DOI: 10.1001/archinte.158.21.2341.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedCause of DeathCohort StudiesConnecticutCoronary DiseaseDeath CertificatesDepressionFemaleForecastingHospitalizationHumansIncidenceInterviews as TopicMaleMedical AuditMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionReproducibility of ResultsRisk FactorsSex FactorsSurvival RateConceptsCoronary heart diseaseCHD risk factorsDepressive symptomsRisk factorsCHD outcomesHeart diseaseAge-adjusted relative riskImpaired physical functionIncident coronary diseasePhysical function impairmentIncident CHD eventsNonfatal myocardial infarctionIndependent risk factorMedical chart reviewHealthy older womenCause of deathCHD deathCHD eventsCHD mortalityChart reviewCHD incidenceCoronary diseaseFunction impairmentPhysical functionElderly men