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I. George Miller Jr, MD

John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry

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I. George Miller Jr, MD

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Dr. Miller’s laboratory studies the mechanisms underlying the switch between latency and lytic replication of two oncogenic herpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Current experiments explore how viral and cellular transcription factors that selectively bind to methylated DNA control expression of viral and cellular genes, how cellular gene expression is selectively inhibited while viral gene expression is enhanced, and how viral DNA replication is regulated by cellular proteins. Recent studies focus on a new class of anti-viral agents that inhibit reactivation of Epstein-Barr virus from latency into lytic infection.

Education & Training

  • Research Fellow
    Children's Hospital, Boston (1969)
  • Research Fellow
    Harvard Medical School (1969)
  • Fellow
    CDC (1966)
  • Intern & Assistant Resident
    University Hospital, Cleveland (1964)
  • MD
    Harvard Medical School (1962)
  • AB
    Harvard College (1958)


  • Board Certification
    AB of Internal Medicine, Internal Medicine (1972)

Departments & Organizations