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Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Affiliated Faculty, Yale Institute for Global Health; Section Chief, Infectious Diseases, Internal Medicine

Contact Information

Erol Fikrig, MD

Patient Care Location

Office Location



My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, flaviviral infections including dengue and West Nile viruses, and malaria. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Flaviviruses and Plasmodium are used as models  to understand the molecular interactions between pathogens, their arthropod vectors and their mammalian hosts. Finally, we are developing new  approaches to prevent ticks and mosquitoes from feeding on a vertebrate host, thereby interfering with pathogen transmission.

Education & Training

  • Fellow
    Yale University School of Medicine (1991)
  • Resident
    Vanderbilt University Hospital (1988)
  • MD
    Cornell University (1985)
  • BA
    Cornell University, Chemistry (1981)


  • Acquired Tick Resistance
    Amsterdam, NH, Netherlands 2022
    16th International Conference on Lyme Disease
  • Borrelia-Tick Interactions
    San Francisco, CA, United States 2022
    Visiting Professor
  • Arthropod-Pathogen-Host Interactions
    Singapore, Singapore 2021
    International Conference on Vector-borne Diseases
  • Flavivirus-host interactions
    Killarney, KY, Ireland 2019
    Keystone Symposia: Positive-strand RNA viruses
  • Vaccines against Arthropod-borne Diseases
    Washington, DC, United States 2019
    NIH Seminar Series
  • Arthropod Saliva and Pathogenesis
    Falmouth, MA, United States 2018
    Biology of Parasitism
  • Novel Lyme disease Vaccines
    Atlanta, GA, United States 2018
    15th International Congress on Lyme Borreliosis
  • Arthropod-Pathogen-Vector Interactions
    Shenzhen, Guangdong Province, China 2018
    2nd International Symposium on Vector-borne Diseases
  • Arthropod-Pathogen Interactions
    Orlando, FL, United States 2016
    International Congress of Entomology
  • Arthropod saliva as vaccine targets
    Baltimore, MD, United States 2016
    14th Annual Biodefense and Emerging Diseases Conference
  • Anaplasmosis
    Big Sky, MT, United States 2016
    International Meeting of the American Society of Rickettsiology
  • Lyme borreliosis
    Český Krumlov, South Bohemian Region, Czech Republic 2015
    Keynote Address: Tick-borne Disease Conference
  • Vector-Pathogen Interactions
    Taos, NM, United States 2015
    Keynote Speaker: Symposia on The Arthropod Vector
  • Lyme disease pathogenesis
    Newport Beach, CA, United States 2014
    Biology of Spirochetes
  • Flaviviral Pathogenesis
    Lake George, NY, United States 2013
    Northeast Biodefense Conference
  • Borrelia-tick Interactions
    Kraków, Lesser Poland Voivodeship, Poland 2013
    Keynote Speaker: Insect Immunology
  • Tick-borne diseases
    New York, NY, United States 2012
    DeGraff Lecturer
  • Pathogenesis of Tick-borne Diseases
    Chicago, IL, United States 2011
    Plenary Speaker: AAP/ASCI
  • Lyme disease pathogenesis
    Nashville, TN, United States 2010
    M. Glenn Koening Visiting Professor

Honors & Recognition

AwardAwarding OrganizationDate
Merit AwardNational Institute of Health2016
Ruysch Visiting ProfessorUniversity of Amsterdam2014
Frontiers of Science ProfessorAbo Akademi University2013
MemberAssociation of American Physicians2008
MemberHenry Kunkel Society2007
Boerhaave Professor Leiden University2005
MemberInterurban Clinical Club2002
Clinical Scientist in Translational Research AwardBurroughs Wellcome Foundation2002
Established Investigator AwardAmerican Heart Association2002
MemberAmerican Society for Clinical Investigation1998
FellowInfectious Disease Society of America1998
Pew Scholar in the Biomedical SciencesPew Foundation1997
Young Investigator AwardInfectious Disease Society of America1993
Dean's Young Faculty AwardYale University School of Medicine1992
Daland FellowAmerican Philosophical Society1990
Phi Beta KappaCornell University1980

Professional Service

NIH Tick Borne Disease GroupTick-borne Disease Group2021 - Present
ASMGuest Editor2020 - 2021
Journal of Infectious DiseasesReviewer2018 - 2019
Cold Spring Harbor Banbury Center ConferenceConference on Immunity against Lyme disease2017
Connecticut Agricultural Experiment StationBoard Member2016 - Present
Vector Biology Study SectionMember2016 - 2020
Cold Spring Harbor, Lyme Diagnostics SymposiumChairperson2016
European Tick Vaccine Consortium, European UnionAdvisor2015 - 2022
Finland National Science InstituteReviewer2014 - 2015
Journal of Clinical InvestigationReviewer2012 - 2018
HHMIReviewer2012 - 2013
Journal of Experimental MedicineReviewer2008 - 2009
ScienceReviewer2005 - 2017
Bacteriology Study SectionMember2000 - 2004
NatureReviewer2000 - 2021

Departments & Organizations