Infertility, Female; Pregnancy; Reproduction; Vitamin D
Public Health Interests
Epidemiology Methods; Perinatal Epidemiology; Pregnancy; Prenatal/Fetal Development; Reproductive Biology; Reproductive Health
My research program is targeted towards understanding factors related to fertility, early pregnancy biology and pregnancy outcomes, with the ultimate goal of improving the health of women and children. My research interests have focused on 1) investigating environmental and nutritional exposures that can influence fertility or early pregnancy, 2) describing early pregnancy events that are poorly understood and investigating their associations with pregnancy outcomes, 3) developing high-quality and innovative research methods for perinatal epidemiologic research.
Extensive Research Description
Subfecundity (difficulty conceiving a pregnancy) is a pressing public health problem that affects approximately 6.7 million U.S. women with 1.5 million estimated to be infertile. Factors that affect fertility are not well-understood. I have investigated the influence of environmental chemicals (phthalates and phenols) and nutritional factors (vitamin D) on fertility. Vitamin D is hypothesized to influence both fertility and early pregnancy, making it an ideal exposure for someone with my background and interests. If vitamin D is important for reproductive function it would be easy to assess clinically, and serve as a low-cost intervention for regulating menstrual cycles and improving fertility. I have published three studies showing a higher odds of irregular or long menstrual cycles in women with lower 25(OH)D. Moreover, high levels of vitamin D were associated with improved fertility. This research suggests that fertility may be improved by increasing women's vitamin D levels. Vitamin D is a low-cost, widely available supplement that could shorten the time it takes a woman to conceive, saving her time and the costs of infertility evaluations or treatments. My research will further explore this possibility.
In addition to these primary research projects I am working on an investigation of microRNA and early placental development. MicroRNA (miRNA) are small non-coding RNA that regulate gene expression. I also work with colleagues in Norway to investigate the placenta - how exposures influence placental development and how placental development may be influenced by pregnancy complications. Other Norwegian datasets can be used to investigate childhood health outcomes such as cerebral palsy and neurodevelopment.
- Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision. Am J Epidemiol. 2017 Aug 17. doi: 10.1093/aje/kwx297.
Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women
Fertility and Sterility, 2016; 106(1):172-179
Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.
Fertility and Sterility, 2016; 105(6): 1584-1588.e1
Long-term recall of time to pregnancy
Epidemiology, 2016; 27(5):705-711
Urinary concentrations of pthalate metabolites and Bisphenol A and associations with follicular-phase length, luteal-phase length, fecundability, and early pregnancy loss
Environ Health Perspect, 2016; 124(3):321-328
The impact of systematic errors on gestational age estimation.
British Journal of Obstetrics and Gynaecology, 2015; 122(6):842.
Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study.
Reproductive Biology and Endocrinology 2015; 13(1):20.
Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women.
Menopause 2015; 22(3):312-6.
Length of human pregnancy and contributors to its natural variation.
Human Reproduction, 2013; 28(10):2848-2855.
Full List of PubMed Publications
- Jukic AMZ, Baird DD, Wilcox AJ, Weinberg CR, Steiner AZ: 25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve. Menopause. 2018 Mar 5; 2018 Mar 5. PMID: 29509595
- Adeyinka O, Jukic AM, McGarvey ST, Muasau-Howard BT, Faiai M, Hawley NL: Predictors of prenatal care satisfaction among pregnant women in American Samoa. BMC Pregnancy Childbirth. 2017 Nov 16; 2017 Nov 16. PMID: 29145810
- Chin HB, Baird DD, McConnaughey DR, Weinberg CR, Wilcox AJ, Jukic AM: Long-term Recall of Pregnancy-related Events. Epidemiology. 2017 Jul. PMID: 28346268
- Jukic AM, McConnaughey DR, Weinberg CR, Wilcox AJ, Baird DD: Long-term Recall of Time to Pregnancy. Epidemiology. 2016 Sep. PMID: 27487038
- Jukic AM: Voices: A Conversation with Allen J. Wilcox. Epidemiology. 2016 Sep. PMID: 27482869
- Jukic AMZ, Upson K, Harmon QE, Baird DD: Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women. Fertil Steril. 2016 Jul; 2016 Mar 18. PMID: 26997249
- Steiner AZ, Jukic AM: Impact of female age and nulligravidity on fecundity in an older reproductive age cohort. Fertil Steril. 2016 Jun; 2016 Mar 5. PMID: 26953733