Study Finds Enzyme in the Brain Is a ‘Metastat’ for Body Weight
Researchers found that removing the enzyme from neurons in a part of the brain known as the hypothalamus led mice to gain weight and burn less fat. This finding, they say, suggests that the enzyme could be a target for treating metabolic disease.Source: YaleNews
Yale researchers show how the liver can control the brain and behavior
A new Yale study found that the liver plays a major role in regulating feeding behavior in mice, a discovery that could have implications for people with eating disorders and metabolic diseases. The study, which was done in collaboration with colleagues in Germany, also adds to a growing body of evidence that shows the most advanced part of the brain, the cerebral cortex, is affected by the rest of the body, not just the other way around.Source: YaleNews
Biology of Aging Study Shows Why Curbing Calories Counts
The Director of the National Institutes of Health notes two recent studies, including one from the Yale Center for Research on Aging (Y-Age), that suggest that calorie restriction may improve immune function and reduce chronic inflammation.Source: National Institute of Health Director's Blog
Carlos Fernández-Hernando, PhD, Appointed Director of Vascular Biology & Therapeutics Program at Yale School of Medicine
Carlos Fernández-Hernando, PhD, Anthony N. Brady Professor of Comparative Medicine and Pathology, was appointed as Director of the Vascular Biology & Therapeutics Program at Yale School of Medicine effective February 1.
Rethinking the Drivers Behind Weight Gain—YMSM Welcomes Guest Lecturer John Speakman
“It was thought anecdotally that we had become less active, and as a result, had increased susceptibility to weight gain,” says Anton Bennett, PhD, Dorys McConnell Duberg Professor of Pharmacology, professor of comparative medicine, and director of Yale Center for Molecular and Systems Metabolism. “That is not the case. Energy expenditure is not part of the obesity story.”
Molecular ‘Doormen’ Open the Way to Potential Obesity Treatment
In obese individuals, cellular "doormen" open the gates far too wide in certain key fat cells, known as visceral fat cells, letting in too many carbohydrates without first burning off lipids. This leads to a ballooning of the size of visceral fat cells in the belly.
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
Abstract Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The visceral fat is highly susceptible to the availability of external nutrients. Moreover, adipose OGT overexpression inhibits lipolysis and promotes diet-induced obesity. These findings establish an essential role for OGT in adipose tissue homeostasis and indicate a unique potential for targeting O-GlcNAc signaling in the treatment of obesity.Source: Nature Communications
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis
A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.Source: Cell Metabolism
Yale-led study finds surprise link between metabolism and immunity
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Blavatnik Fund awards grants for innovation
Several faculty members won research grants from the Blavatnik Fund for Innovation at Yale at the fourth annual Yale Innovation Summit on May 10. The summit, presented by the Office of Cooperative Research (OCR) and Yale Entrepreneurial Institute, provides a window into an expanding entrepreneurial ecosystem at Yale.