2021
Hepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archivesCan primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasis
2019
Histologic patterns of liver injury induced by anti-PD-1 therapy
Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2019, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.Peer-Reviewed Original ResearchAnti-PD-1 therapyAnti-PD-1 treatmentLiver function testsHistologic patternAutoimmune hepatitisAdvanced malignanciesLiver injuryAbnormal liver function testsAnti-PD-1 agentsClassical autoimmune hepatitisLiver chemistry testsMultiple advanced malignanciesPD-1 inhibitorsSevere liver injuryCell death 1Different histologic patternsCholestatic injuryHepatitis panelSteroid therapyAbdominal painAcute hepatitisGastrointestinal symptomsImmunosuppressive therapyDrug cessationHistologic injury
2016
Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications
Lisovsky M, Westerhoff M, Zhang X. Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications. Annals Of The New York Academy Of Sciences 2016, 1381: 133-138. PMID: 27635640, DOI: 10.1111/nyas.13260.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocytesCrohn's diseaseCommon clinical manifestationsNormal endoscopic appearanceLymphocytic esophagitisSignificant granulocytosisEndoscopic appearanceEosinophilic esophagitisMotility abnormalitiesMotility disordersClinical manifestationsHistologic patternClinical correlatesClinical significanceAssociated diseasePossible associationClinical ramificationsDiseaseEsophagitisAdultsAssociationDysphagiaCD4GranulocytosisEsophagus