2024
Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-omicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples
2023
DIFFERENTIAL PAIN SENSATION AND GUT MICROBIOME BETWEEN YOUNG AND OLDER ADULTS
Chen J, Wang Z, Starkweather A, Chen M, Miao H, Ahn H, Cong X. DIFFERENTIAL PAIN SENSATION AND GUT MICROBIOME BETWEEN YOUNG AND OLDER ADULTS. Innovation In Aging 2023, 7: 800-800. PMCID: PMC10737760, DOI: 10.1093/geroni/igad104.2582.Peer-Reviewed Original ResearchCold pain thresholdHeat pain thresholdCold detection thresholdGut microbiota profilePressure pain thresholdPain thresholdShannon indexMicrobiota profilesChao indexBeta diversity indicesLower cold pain thresholdStool samplesHigher pressure pain thresholdsQuantitative sensory testing dataYoung adultsAbundant taxaPeripheral sensationAge of young adultsGut microbiotaDiversity indexA-diversityPain sensationSpearman correlation analysisPain processingHigher speciesPain sensation and gut microbiota profiles in older adults with heart failure
Chen J, Wang Z, Starkweather A, Chen M, McCauley P, Miao H, Ahn H, Cong X. Pain sensation and gut microbiota profiles in older adults with heart failure. Interdisciplinary Nursing Research 2023, 2: 83-91. PMID: 37645375, PMCID: PMC10461724, DOI: 10.1097/nr9.0000000000000024.Peer-Reviewed Original ResearchSelf-reported painPain sensationHeart failureHealthy controlsHF subjectsBiomarkers of painPain modulationSevere self-reported painStool samplesGut microbiota compositionQuantitative sensory testing profilesConditioned pain modulationQuantitative sensory testingPressure pain thresholdAssociated with painBrief Pain InventorySymptoms of HFImprove pain managementSubjects' mean ageNIH Patient-Reported Outcomes Measurement Information SystemOlder adultsMicrobiota compositionGut microbiotaPatient-Reported Outcomes Measurement Information SystemPain intensityThe Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2022
Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization
Chen J, Li H, Maas K, Starkweather A, Chen M, Cong X. Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization. Interdisciplinary Nursing Research 2022, 1: 6-13. PMID: 36590867, PMCID: PMC9766955, DOI: 10.1097/nr9.0000000000000004.Peer-Reviewed Original ResearchGut microbiome profilesNeonatal intensive care unitNeonatal intensive care unit hospitalizationMicrobiome profilesGut microbiotaPreterm infantsStool samplesComposition of gut microbiotaPredicted metabolic functionsPredictive functional profilingNeonatal gut microbiotaBacterial taxonomic compositionGut microbiota compositionAbundance of membranePreterm neonatesGlycan biosynthesisLipopolysaccharide biosynthesisNeonatal intensive care hospitalizationTaxonomic compositionGene regionB-diversityGut microbiomeMicrobiota compositionMale preterm neonatesDiversity index