2021
Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes
Liu X, Cong X, Li G, Maas K, Chen K. Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes. Statistics In Medicine 2021, 41: 580-594. PMID: 34897772, DOI: 10.1002/sim.9273.Peer-Reviewed Original ResearchConceptsLinear log-contrast modelLog-contrast modelGut microbiomeGut microbiome of preterm infantsHypothesis testing procedureInfant gut microbiomeLinear constraintsCompositional covariatesInference proceduresMultivariate responsePenalization approachSimulation studyGroup structureMicrobiome dataIdentified microbesMicrobiome analysisTaxonomic hierarchyInference methodsPreterm infant studyTest procedureMicrobiomeMicrobesBiological understandingCovariatesFeature matrix
2020
Altered Composition of Gut Microbiota in Depression: A Systematic Review
Barandouzi Z, Starkweather A, Henderson W, Gyamfi A, Cong X. Altered Composition of Gut Microbiota in Depression: A Systematic Review. Frontiers In Psychiatry 2020, 11: 541. PMID: 32587537, PMCID: PMC7299157, DOI: 10.3389/fpsyt.2020.00541.Peer-Reviewed Original ResearchGut microbiota patternMicrobiota patternsComposition of gut microbiotaLow abundanceClostridium IV</i>Clostridium XlVa</i>Gut microbiome patternsBrain-gut-microbiome axisGenus levelGut microbiotaB-diversityGut microbiomePhylum levelA-diversityMicrobiome patternsGastrointestinal microbiomeFamily levelMicrobiome findingsMicrobiotaAltered compositionAbundanceGutHealthy controlsMicrobiomeDepressive disorder
2019
A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes
Lew K, Starkweather A, Cong X, Judge M. A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes. Biological Research For Nursing 2019, 21: 384-399. PMID: 31113222, DOI: 10.1177/1099800419849109.Peer-Reviewed Original ResearchConceptsGut-brain axisGut-brain axis pathwayHigh-fat dietDNA sequencing technologiesPro-inflammatory pathwaysMechanistic modelSequencing technologiesGut microbiomeHuman microbiomeHomeostatic disruptionProgression of T2DInsulin resistanceNonmodifiable risk factorsSystemic inflammationGutHigh-fatMicrobiomePathwayHomeostatic imbalanceMetabolic diseasesRisk factorsLow-grade systemic inflammationAmerican populationTranslocation of endotoxinWall permeability
2016
Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.
Cong X, Xu W, Romisher R, Poveda S, Forte S, Starkweather A, Henderson W. Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors. The Yale Journal Of Biology And Medicine 2016, 89: 299-308. PMID: 27698614, PMCID: PMC5045139.Peer-Reviewed Original ResearchConceptsGut microbiomeNeonatal intensive care unitDysbiosis of gut microbiotaSignaling systemHost-microbial interactionsNeonatal gut microbiomeGut microbiotaEvolutionary trajectoriesHigh-risk preterm infantsHost geneticsDysbiosis patternsLong-term infant healthIntensive care unitMicrobiomePreterm infantsEarly life stressGeneticsHuman newbornsRegulation of healthCare unitNeurodevelopmental processesInfant healthHostMedication useDelivery mode
2015
Early Life Experience and Gut Microbiome
Cong X, Henderson W, Graf J, McGrath J. Early Life Experience and Gut Microbiome. Advances In Neonatal Care 2015, 15: 314-323. PMID: 26240939, PMCID: PMC4583334, DOI: 10.1097/anc.0000000000000191.Peer-Reviewed Original ResearchConceptsGut microbiomeHigh-risk infantsStressful early life experiencesCentral nervous systemSignaling systemPreterm infantsIntestinal innate immunityPain responseBrain-gut-microbiota axisNeonatal careEarly life experiencesNeuroimmune systemMicrobial speciesNervous systemInnate immunityRegulation mechanismInfantsGutMicrobiomeTargeted interventionsRegulationModulating stressPretermState-of-the-science reviewComplex mechanisms